High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans

Pulmonary tuberculosis (TB) is a major worldwide health problem that lacks robust blood-based biomarkers for detection of active disease. High-resolution metabolomics (HRM) is an innovative method to discover low-abundance metabolites as putative blood biomarkers to detect TB disease, including thos...

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Veröffentlicht in:	PloS one 2018-10, Vol.13 (10), p.e0205398-e0205398
Hauptverfasser:	Collins, Jeffrey M, Walker, Douglas I, Jones, Dean P, Tukvadze, Nestani, Liu, Ken H, Tran, ViLinh T, Uppal, Karan, Frediani, Jennifer K, Easley, Kirk A, Shenvi, Neeta, Khadka, Manoj, Ortlund, Eric A, Kempker, Russell R, Blumberg, Henry M, Ziegler, Thomas R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Biochemistry Bioinformatics Biology and Life Sciences Biomarkers Biomarkers - blood Blood Carrier State - blood Carrier State - diagnosis Cell culture Critical care Cross-Sectional Studies Diagnostic tests Dissociation Endocrinology Family Characteristics High resolution HIV Human immunodeficiency virus Humans In vivo methods and tests Infectious diseases Laboratories Lipids Lung diseases Lysophospholipids - analysis Mass spectrometry Medicine Medicine and Health Sciences Metabolism Metabolites Metabolomics Metabolomics - methods Methods Microorganisms Middle Aged Mycobacterium tuberculosis Mycobacterium tuberculosis - metabolism Pathogens Patients Phosphatidylglycerol Phosphatidylglycerols - analysis Plasma Public health Retention time Scientific imaging Tandem Mass Spectrometry Tuberculosis Tuberculosis, Pulmonary - blood Tuberculosis, Pulmonary - diagnosis Urine Young Adult
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