Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

The results from cross sectional and longitudinal studies show that periodontitis is closely associated with cognitive impairment (CI) and Alzhemer's Disease (AD). Further, studies using animal model of periodontitis and human post-mortem brain tissues from subjects with AD strongly suggest tha...

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Veröffentlicht in:	PloS one 2018-10, Vol.13 (10), p.e0204941-e0204941
Hauptverfasser:	Ilievski, Vladimir, Zuchowska, Paulina K, Green, Stefan J, Toth, Peter T, Ragozzino, Michael E, Le, Khuong, Aljewari, Haider W, O'Brien-Simpson, Neil M, Reynolds, Eric C, Watanabe, Keiko
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM10 Protein - genetics Administration, Oral Age Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - microbiology Alzheimer Disease - pathology Alzheimer's disease Alzheimers disease Amyloid beta-Peptides - biosynthesis Amyloid beta-Peptides - metabolism Amyloid beta-protein Amyloid precursor protein Amyloid Precursor Protein Secretases - genetics Anaerobic bacteria Animal cognition Animals Aspartic Acid Endopeptidases - genetics Astrocytes Astrocytes - pathology b-Site APP cleaving enzyme 1 Biology and Life Sciences Brain Cell Count Chronic infection Cognitive ability Cognitive Dysfunction - genetics Cognitive Dysfunction - metabolism Cognitive Dysfunction - microbiology Cognitive Dysfunction - pathology Confocal microscopy Correlation analysis Cross-Sectional Studies Dementia Dentistry DNA-Binding Proteins Encephalitis - genetics Encephalitis - metabolism Encephalitis - microbiology Encephalitis - pathology Frontal Lobe - pathology Gender differences Gene expression Gene Expression Regulation Gingipain Glial fibrillary acidic protein Gliosis Gum disease Hippocampus Hippocampus - metabolism Hippocampus - pathology Immunofluorescence Immunohistochemistry Immunology Inflammation Interleukin 1 Interleukin 6 Intracellular Space - metabolism Longitudinal studies Male Medicine and Health Sciences Mice Mice, Inbred C57BL Microglia Microglia - pathology Microscopy Nerve Tissue Proteins - metabolism Neurodegeneration Neurofibrillary tangles Neurons Neurons - pathology Nuclear Proteins - metabolism Oral administration Pathogens Peptide Fragments - biosynthesis Peptide Fragments - metabolism Periodontics Periodontitis - microbiology Phosphorylation Porphyromonas gingivalis - physiology Presenilin-1 - genetics Proteins Research and Analysis Methods Risk factors Secretase Statistical analysis Studies tau Proteins - metabolism Tissues Translocation β-Site APP-cleaving enzyme 1
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