Outcomes of endovascular treatment versus bypass surgery for critical limb ischemia in patients with thromboangiitis obliterans
We aimed to compare the clinical outcomes between endovascular treatment and inframalleolar bypass surgery for critical limb ischemia (CLI) in patients with thromboangiitis obliterans (TAO) and to assess the role of bypass surgery in the era of innovative endovascular treatment. Between January 2007...
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description | We aimed to compare the clinical outcomes between endovascular treatment and inframalleolar bypass surgery for critical limb ischemia (CLI) in patients with thromboangiitis obliterans (TAO) and to assess the role of bypass surgery in the era of innovative endovascular treatment. Between January 2007 and December 2017, a total of 33 consecutive patients with the diagnosis of TAO presenting with CLI who underwent endovascular treatment (endovascular group, n = 22) or bypass surgery to the pedal or plantar vessels (bypass group, n = 11) were included and analyzed retrospectively. The primary endpoint was defined as a major amputation of the index limb, and the secondary endpoint was defined as graft occlusion, regardless of the number of subsequent procedures. In the bypass group, six patients (55%) had undergone previous failed endovascular procedures and/or arterial bypass surgery to the index limb before inframalleolar bypass, and two patients (18%) received microvascular flap reconstruction after bypass surgery. During the median follow-up period of 32 months (range 1-115 months), there were no significant differences in primary and secondary endpoints between the two groups although the bypass group had a higher Rutherford class than the endovascular group. Kaplan-Meier survival analysis showed that there were similar limb salvage (P = 0.95) and graft patency rates (P = 0.39). In conclusion, endovascular treatment is a valid strategy leading to an acceptable limb salvage rate for TAO patients, and surgical bypass to distal target vessels could play a vital role in cases of previous failed endovascular treatment or extensive soft tissue loss of the foot. |
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Between January 2007 and December 2017, a total of 33 consecutive patients with the diagnosis of TAO presenting with CLI who underwent endovascular treatment (endovascular group, n = 22) or bypass surgery to the pedal or plantar vessels (bypass group, n = 11) were included and analyzed retrospectively. The primary endpoint was defined as a major amputation of the index limb, and the secondary endpoint was defined as graft occlusion, regardless of the number of subsequent procedures. In the bypass group, six patients (55%) had undergone previous failed endovascular procedures and/or arterial bypass surgery to the index limb before inframalleolar bypass, and two patients (18%) received microvascular flap reconstruction after bypass surgery. During the median follow-up period of 32 months (range 1-115 months), there were no significant differences in primary and secondary endpoints between the two groups although the bypass group had a higher Rutherford class than the endovascular group. Kaplan-Meier survival analysis showed that there were similar limb salvage (P = 0.95) and graft patency rates (P = 0.39). In conclusion, endovascular treatment is a valid strategy leading to an acceptable limb salvage rate for TAO patients, and surgical bypass to distal target vessels could play a vital role in cases of previous failed endovascular treatment or extensive soft tissue loss of the foot.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0205305</identifier><identifier>PMID: 30300407</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Amputation ; Amputation - mortality ; Amputation - statistics & numerical data ; Aneurysms ; Atherosclerosis ; Biology and Life Sciences ; Blood vessels ; Cardiovascular system ; Endovascular Procedures - methods ; Endovascular Procedures - mortality ; Female ; Foot diseases ; Graft Occlusion, Vascular - mortality ; Graft Occlusion, Vascular - pathology ; Heart surgery ; Humans ; Ischemia ; Ischemia - mortality ; Ischemia - pathology ; Ischemia - surgery ; Limb Salvage - mortality ; Limb Salvage - statistics & numerical data ; Lower Extremity - blood supply ; Lower Extremity - pathology ; Lower Extremity - surgery ; Male ; Medical imaging ; Medicine ; Medicine and Health Sciences ; Microvasculature ; Middle Aged ; Occlusion ; Patients ; Retrospective Studies ; Salvage ; Saphenous Vein - pathology ; Saphenous Vein - surgery ; Society ; Surgery ; Survival Analysis ; Thromboangiitis obliterans ; Thromboangiitis Obliterans - mortality ; Thromboangiitis Obliterans - pathology ; Thromboangiitis Obliterans - surgery ; Vascular Grafting - methods ; Vascular Grafting - mortality ; Vascular surgery</subject><ispartof>PloS one, 2018-10, Vol.13 (10), p.e0205305-e0205305</ispartof><rights>2018 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Lee et al 2018 Lee et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-7427471961b5cad089bd77d4182fe2dccc36b31f9bd8287ccd0bdb728e0efac93</citedby><cites>FETCH-LOGICAL-c526t-7427471961b5cad089bd77d4182fe2dccc36b31f9bd8287ccd0bdb728e0efac93</cites><orcidid>0000-0002-0639-451X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177182/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177182/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23847,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30300407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rade, Jeffrey J.</contributor><creatorcontrib>Lee, Chung Yeop</creatorcontrib><creatorcontrib>Choi, Kyunghak</creatorcontrib><creatorcontrib>Kwon, Hyunwook</creatorcontrib><creatorcontrib>Ko, Gi-Young</creatorcontrib><creatorcontrib>Han, Youngjin</creatorcontrib><creatorcontrib>Kwon, Tae-Won</creatorcontrib><creatorcontrib>Cho, Yong-Pil</creatorcontrib><title>Outcomes of endovascular treatment versus bypass surgery for critical limb ischemia in patients with thromboangiitis obliterans</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We aimed to compare the clinical outcomes between endovascular treatment and inframalleolar bypass surgery for critical limb ischemia (CLI) in patients with thromboangiitis obliterans (TAO) and to assess the role of bypass surgery in the era of innovative endovascular treatment. Between January 2007 and December 2017, a total of 33 consecutive patients with the diagnosis of TAO presenting with CLI who underwent endovascular treatment (endovascular group, n = 22) or bypass surgery to the pedal or plantar vessels (bypass group, n = 11) were included and analyzed retrospectively. The primary endpoint was defined as a major amputation of the index limb, and the secondary endpoint was defined as graft occlusion, regardless of the number of subsequent procedures. In the bypass group, six patients (55%) had undergone previous failed endovascular procedures and/or arterial bypass surgery to the index limb before inframalleolar bypass, and two patients (18%) received microvascular flap reconstruction after bypass surgery. During the median follow-up period of 32 months (range 1-115 months), there were no significant differences in primary and secondary endpoints between the two groups although the bypass group had a higher Rutherford class than the endovascular group. Kaplan-Meier survival analysis showed that there were similar limb salvage (P = 0.95) and graft patency rates (P = 0.39). In conclusion, endovascular treatment is a valid strategy leading to an acceptable limb salvage rate for TAO patients, and surgical bypass to distal target vessels could play a vital role in cases of previous failed endovascular treatment or extensive soft tissue loss of the foot.</description><subject>Adult</subject><subject>Aged</subject><subject>Amputation</subject><subject>Amputation - mortality</subject><subject>Amputation - statistics & numerical data</subject><subject>Aneurysms</subject><subject>Atherosclerosis</subject><subject>Biology and Life Sciences</subject><subject>Blood vessels</subject><subject>Cardiovascular system</subject><subject>Endovascular Procedures - methods</subject><subject>Endovascular Procedures - mortality</subject><subject>Female</subject><subject>Foot diseases</subject><subject>Graft Occlusion, Vascular - mortality</subject><subject>Graft Occlusion, Vascular - pathology</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Ischemia - mortality</subject><subject>Ischemia - pathology</subject><subject>Ischemia - surgery</subject><subject>Limb Salvage - mortality</subject><subject>Limb Salvage - statistics & numerical data</subject><subject>Lower Extremity - blood supply</subject><subject>Lower Extremity - pathology</subject><subject>Lower Extremity - surgery</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Microvasculature</subject><subject>Middle Aged</subject><subject>Occlusion</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Salvage</subject><subject>Saphenous Vein - pathology</subject><subject>Saphenous Vein - surgery</subject><subject>Society</subject><subject>Surgery</subject><subject>Survival Analysis</subject><subject>Thromboangiitis obliterans</subject><subject>Thromboangiitis Obliterans - mortality</subject><subject>Thromboangiitis Obliterans - pathology</subject><subject>Thromboangiitis Obliterans - 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mortality</topic><topic>Amputation - statistics & numerical data</topic><topic>Aneurysms</topic><topic>Atherosclerosis</topic><topic>Biology and Life Sciences</topic><topic>Blood vessels</topic><topic>Cardiovascular system</topic><topic>Endovascular Procedures - methods</topic><topic>Endovascular Procedures - mortality</topic><topic>Female</topic><topic>Foot diseases</topic><topic>Graft Occlusion, Vascular - mortality</topic><topic>Graft Occlusion, Vascular - pathology</topic><topic>Heart surgery</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Ischemia - mortality</topic><topic>Ischemia - pathology</topic><topic>Ischemia - surgery</topic><topic>Limb Salvage - mortality</topic><topic>Limb Salvage - statistics & numerical data</topic><topic>Lower Extremity - blood supply</topic><topic>Lower Extremity - pathology</topic><topic>Lower Extremity - surgery</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Microvasculature</topic><topic>Middle Aged</topic><topic>Occlusion</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Salvage</topic><topic>Saphenous Vein - pathology</topic><topic>Saphenous Vein - surgery</topic><topic>Society</topic><topic>Surgery</topic><topic>Survival Analysis</topic><topic>Thromboangiitis obliterans</topic><topic>Thromboangiitis Obliterans - mortality</topic><topic>Thromboangiitis Obliterans - pathology</topic><topic>Thromboangiitis Obliterans - surgery</topic><topic>Vascular Grafting - methods</topic><topic>Vascular Grafting - mortality</topic><topic>Vascular surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Chung Yeop</creatorcontrib><creatorcontrib>Choi, Kyunghak</creatorcontrib><creatorcontrib>Kwon, Hyunwook</creatorcontrib><creatorcontrib>Ko, Gi-Young</creatorcontrib><creatorcontrib>Han, Youngjin</creatorcontrib><creatorcontrib>Kwon, Tae-Won</creatorcontrib><creatorcontrib>Cho, Yong-Pil</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Chung Yeop</au><au>Choi, Kyunghak</au><au>Kwon, Hyunwook</au><au>Ko, Gi-Young</au><au>Han, Youngjin</au><au>Kwon, Tae-Won</au><au>Cho, Yong-Pil</au><au>Rade, Jeffrey J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes of endovascular treatment versus bypass surgery for critical limb ischemia in patients with thromboangiitis obliterans</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-10-09</date><risdate>2018</risdate><volume>13</volume><issue>10</issue><spage>e0205305</spage><epage>e0205305</epage><pages>e0205305-e0205305</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We aimed to compare the clinical outcomes between endovascular treatment and inframalleolar bypass surgery for critical limb ischemia (CLI) in patients with thromboangiitis obliterans (TAO) and to assess the role of bypass surgery in the era of innovative endovascular treatment. Between January 2007 and December 2017, a total of 33 consecutive patients with the diagnosis of TAO presenting with CLI who underwent endovascular treatment (endovascular group, n = 22) or bypass surgery to the pedal or plantar vessels (bypass group, n = 11) were included and analyzed retrospectively. The primary endpoint was defined as a major amputation of the index limb, and the secondary endpoint was defined as graft occlusion, regardless of the number of subsequent procedures. In the bypass group, six patients (55%) had undergone previous failed endovascular procedures and/or arterial bypass surgery to the index limb before inframalleolar bypass, and two patients (18%) received microvascular flap reconstruction after bypass surgery. During the median follow-up period of 32 months (range 1-115 months), there were no significant differences in primary and secondary endpoints between the two groups although the bypass group had a higher Rutherford class than the endovascular group. Kaplan-Meier survival analysis showed that there were similar limb salvage (P = 0.95) and graft patency rates (P = 0.39). In conclusion, endovascular treatment is a valid strategy leading to an acceptable limb salvage rate for TAO patients, and surgical bypass to distal target vessels could play a vital role in cases of previous failed endovascular treatment or extensive soft tissue loss of the foot.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30300407</pmid><doi>10.1371/journal.pone.0205305</doi><orcidid>https://orcid.org/0000-0002-0639-451X</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adult Aged Amputation Amputation - mortality Amputation - statistics & numerical data Aneurysms Atherosclerosis Biology and Life Sciences Blood vessels Cardiovascular system Endovascular Procedures - methods Endovascular Procedures - mortality Female Foot diseases Graft Occlusion, Vascular - mortality Graft Occlusion, Vascular - pathology Heart surgery Humans Ischemia Ischemia - mortality Ischemia - pathology Ischemia - surgery Limb Salvage - mortality Limb Salvage - statistics & numerical data Lower Extremity - blood supply Lower Extremity - pathology Lower Extremity - surgery Male Medical imaging Medicine Medicine and Health Sciences Microvasculature Middle Aged Occlusion Patients Retrospective Studies Salvage Saphenous Vein - pathology Saphenous Vein - surgery Society Surgery Survival Analysis Thromboangiitis obliterans Thromboangiitis Obliterans - mortality Thromboangiitis Obliterans - pathology Thromboangiitis Obliterans - surgery Vascular Grafting - methods Vascular Grafting - mortality Vascular surgery |
title | Outcomes of endovascular treatment versus bypass surgery for critical limb ischemia in patients with thromboangiitis obliterans |
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