Outcomes of endovascular treatment versus bypass surgery for critical limb ischemia in patients with thromboangiitis obliterans

We aimed to compare the clinical outcomes between endovascular treatment and inframalleolar bypass surgery for critical limb ischemia (CLI) in patients with thromboangiitis obliterans (TAO) and to assess the role of bypass surgery in the era of innovative endovascular treatment. Between January 2007...

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Veröffentlicht in:PloS one 2018-10, Vol.13 (10), p.e0205305-e0205305
Hauptverfasser: Lee, Chung Yeop, Choi, Kyunghak, Kwon, Hyunwook, Ko, Gi-Young, Han, Youngjin, Kwon, Tae-Won, Cho, Yong-Pil
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Choi, Kyunghak
Kwon, Hyunwook
Ko, Gi-Young
Han, Youngjin
Kwon, Tae-Won
Cho, Yong-Pil
description We aimed to compare the clinical outcomes between endovascular treatment and inframalleolar bypass surgery for critical limb ischemia (CLI) in patients with thromboangiitis obliterans (TAO) and to assess the role of bypass surgery in the era of innovative endovascular treatment. Between January 2007 and December 2017, a total of 33 consecutive patients with the diagnosis of TAO presenting with CLI who underwent endovascular treatment (endovascular group, n = 22) or bypass surgery to the pedal or plantar vessels (bypass group, n = 11) were included and analyzed retrospectively. The primary endpoint was defined as a major amputation of the index limb, and the secondary endpoint was defined as graft occlusion, regardless of the number of subsequent procedures. In the bypass group, six patients (55%) had undergone previous failed endovascular procedures and/or arterial bypass surgery to the index limb before inframalleolar bypass, and two patients (18%) received microvascular flap reconstruction after bypass surgery. During the median follow-up period of 32 months (range 1-115 months), there were no significant differences in primary and secondary endpoints between the two groups although the bypass group had a higher Rutherford class than the endovascular group. Kaplan-Meier survival analysis showed that there were similar limb salvage (P = 0.95) and graft patency rates (P = 0.39). In conclusion, endovascular treatment is a valid strategy leading to an acceptable limb salvage rate for TAO patients, and surgical bypass to distal target vessels could play a vital role in cases of previous failed endovascular treatment or extensive soft tissue loss of the foot.
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Between January 2007 and December 2017, a total of 33 consecutive patients with the diagnosis of TAO presenting with CLI who underwent endovascular treatment (endovascular group, n = 22) or bypass surgery to the pedal or plantar vessels (bypass group, n = 11) were included and analyzed retrospectively. The primary endpoint was defined as a major amputation of the index limb, and the secondary endpoint was defined as graft occlusion, regardless of the number of subsequent procedures. In the bypass group, six patients (55%) had undergone previous failed endovascular procedures and/or arterial bypass surgery to the index limb before inframalleolar bypass, and two patients (18%) received microvascular flap reconstruction after bypass surgery. During the median follow-up period of 32 months (range 1-115 months), there were no significant differences in primary and secondary endpoints between the two groups although the bypass group had a higher Rutherford class than the endovascular group. Kaplan-Meier survival analysis showed that there were similar limb salvage (P = 0.95) and graft patency rates (P = 0.39). 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Between January 2007 and December 2017, a total of 33 consecutive patients with the diagnosis of TAO presenting with CLI who underwent endovascular treatment (endovascular group, n = 22) or bypass surgery to the pedal or plantar vessels (bypass group, n = 11) were included and analyzed retrospectively. The primary endpoint was defined as a major amputation of the index limb, and the secondary endpoint was defined as graft occlusion, regardless of the number of subsequent procedures. In the bypass group, six patients (55%) had undergone previous failed endovascular procedures and/or arterial bypass surgery to the index limb before inframalleolar bypass, and two patients (18%) received microvascular flap reconstruction after bypass surgery. During the median follow-up period of 32 months (range 1-115 months), there were no significant differences in primary and secondary endpoints between the two groups although the bypass group had a higher Rutherford class than the endovascular group. Kaplan-Meier survival analysis showed that there were similar limb salvage (P = 0.95) and graft patency rates (P = 0.39). In conclusion, endovascular treatment is a valid strategy leading to an acceptable limb salvage rate for TAO patients, and surgical bypass to distal target vessels could play a vital role in cases of previous failed endovascular treatment or extensive soft tissue loss of the foot.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30300407</pmid><doi>10.1371/journal.pone.0205305</doi><orcidid>https://orcid.org/0000-0002-0639-451X</orcidid><oa>free_for_read</oa></addata></record>
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subjects Adult
Aged
Amputation
Amputation - mortality
Amputation - statistics & numerical data
Aneurysms
Atherosclerosis
Biology and Life Sciences
Blood vessels
Cardiovascular system
Endovascular Procedures - methods
Endovascular Procedures - mortality
Female
Foot diseases
Graft Occlusion, Vascular - mortality
Graft Occlusion, Vascular - pathology
Heart surgery
Humans
Ischemia
Ischemia - mortality
Ischemia - pathology
Ischemia - surgery
Limb Salvage - mortality
Limb Salvage - statistics & numerical data
Lower Extremity - blood supply
Lower Extremity - pathology
Lower Extremity - surgery
Male
Medical imaging
Medicine
Medicine and Health Sciences
Microvasculature
Middle Aged
Occlusion
Patients
Retrospective Studies
Salvage
Saphenous Vein - pathology
Saphenous Vein - surgery
Society
Surgery
Survival Analysis
Thromboangiitis obliterans
Thromboangiitis Obliterans - mortality
Thromboangiitis Obliterans - pathology
Thromboangiitis Obliterans - surgery
Vascular Grafting - methods
Vascular Grafting - mortality
Vascular surgery
title Outcomes of endovascular treatment versus bypass surgery for critical limb ischemia in patients with thromboangiitis obliterans
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