Protection induced by a Francisella tularensis subunit vaccine delivered by glucan particles

Francisella tularensis is an intracellular pathogen causing the disease tularemia, and an organism of concern to biodefence. There is no licensed vaccine available. Subunit approaches have failed to induce protection, which requires both humoral and cellular immune memory responses, and have been ha...

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Veröffentlicht in:	PloS one 2018-10, Vol.13 (10), p.e0200213-e0200213
Hauptverfasser:	Whelan, Adam O, Flick-Smith, Helen C, Homan, Jane, Shen, Zu T, Carpenter, Zoe, Khoshkenar, Payam, Abraham, Ambily, Walker, Nicola J, Levitz, Stuart M, Ostroff, Gary R, Oyston, Petra C F
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols Animals Antibiotics Antigens Bacterial Vaccines - immunology Biology and Life Sciences Cell walls Coculture Techniques Colonization Computer applications Drug delivery systems Epitopes Evaluation Francisella tularensis Fungi Glucan Glucans Glucans - administration & dosage Glucans - chemistry Immune response Immunity, Cellular Immunization Immunological memory Immunology Infections Intracellular Lipopolysaccharides Macrophages - metabolism Medical schools Medicine and Health Sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Pathogens Prevention Proteins Rats Rats, Inbred F344 Research and Analysis Methods Risk factors Rodents Saccharomyces cerevisiae Studies Tularemia Tularemia - immunology Tularemia - prevention & control Vaccines Vaccines, Attenuated - immunology Vaccines, Subunit - immunology
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