CRISPR deletion of MIEN1 in breast cancer cells

Migration and Invasion Enhancer (MIEN1) is an oncogene which is involved in facilitating motility of cancer cells through actin dynamics and gene expression. Increased MIEN1 expression in many types of tumors leads to disease progression and metastatic propensity. It is unclear precisely how MIEN1 i...

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Veröffentlicht in:	PloS one 2018-10, Vol.13 (10), p.e0204976-e0204976
Hauptverfasser:	Van Treuren, Timothy, Vishwanatha, Jamboor K
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Biology Biology and Life Sciences Biotechnology Breast cancer Cancer Cancer cells Cell adhesion & migration Cell morphology Cell proliferation Cell survival Clonal deletion CRISPR CRISPR-Cas systems Cytology Disruption Engineering and Technology Gene expression Genetic aspects Genome editing Genomes Growth factors Immunology Kinases Medical research Medicine and Health Sciences Metastases Metastasis Morphology Mutagenesis Oncogenes Plasmids Prostate cancer Proteins Research and Analysis Methods Tumors
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