High-fat diet suppresses the positive effect of creatine supplementation on skeletal muscle function by reducing protein expression of IGF-PI3K-AKT-mTOR pathway

High-fat (HF) diets in combination with sedentary lifestyle represent one of the major public health concerns predisposing to obesity and diabetes leading to skeletal muscle atrophy, decreased fiber diameter and muscle mass with accumulation of fat tissue resulting in loss of muscle strength. One st...

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Veröffentlicht in:	PloS one 2018-10, Vol.13 (10), p.e0199728
Hauptverfasser:	Ferretti, Renato, Moura, Eliezer Guimarães, Dos Santos, Veridiana Carvalho, Caldeira, Eduardo José, Conte, Marcelo, Matsumura, Cintia Yuri, Pertille, Adriana, Mosqueira, Matias
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adenosine diphosphate Adenosine Diphosphate - chemistry AKT protein Amino acids Analysis Animals Antioxidants Antioxidants - metabolism Atrophy Bioaccumulation Biology and Life Sciences Creatine Creatine - pharmacology Diabetes mellitus Diet Diet therapy Diet, High-Fat - adverse effects Dietary Supplements Health aspects High fat diet Inflammation Insulin resistance Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Kinases Lipids Male Medicine and Health Sciences Muscle contraction Muscle strength Muscle, Skeletal - drug effects Muscle, Skeletal - physiopathology Muscular atrophy Muscular Atrophy - metabolism Obesity Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Physical Sciences Physical training Proteins Proto-Oncogene Proteins c-akt - metabolism Public health Rats Rats, Wistar Resistance training Risk factors Rodents Sedentary behavior Signal Transduction - drug effects Skeletal muscle Temperature TOR protein TOR Serine-Threonine Kinases - metabolism Training
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