Regulation of the NRF2 transcription factor by andrographolide and organic extracts from plant endophytes

The transcription factor NF-E2 Related Factor-2 (NRF2) is an important drug target. Activation of NRF2 has chemopreventive effects in cancer and exerts beneficial effects in a number of diseases, including neurodegenerative diseases, inflammatory diseases, hepatosteatosis, obesity and insulin resist...

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Veröffentlicht in:	PloS one 2018-10, Vol.13 (10), p.e0204853-e0204853
Hauptverfasser:	Wong, Daphne Pei Wen, Ng, Mei Ying, Leung, Jia Yu, Boh, Boon Kim, Lim, Ee Chien, Tan, Shi Hua, Lim, Shuying, Seah, Wen Hui, Hu, Christine Zhiwen, Ho, Boon Chuan, Ng, Daphne Hui Ping, Hagen, Thilo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Antioxidants Binding Sites - drug effects Biochemistry Biology and Life Sciences Bryophyta - chemistry Cancer Carrier Proteins - metabolism Cullin Proteins - chemistry Cullin Proteins - metabolism Diterpenes - chemistry Diterpenes - pharmacology Endophytes Endophytes - chemistry Enzymes Ferns - chemistry Flowering Gene Expression Regulation - drug effects Gene regulation Genetic aspects Genetic regulation HEK293 Cells Herbal medicine Humans Inflammatory diseases Insulin Kelch-Like ECH-Associated Protein 1 - chemistry Kelch-Like ECH-Associated Protein 1 - metabolism Medicine Medicine and Health Sciences Metabolites Neurodegenerative diseases Neurological diseases NF-E2-Related Factor 2 NRF2 protein Oxidative stress Physical Sciences Physiological aspects Plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Plant metabolites Plants (botany) Protein Binding - drug effects Proteins Research and analysis methods Secondary Metabolism Secondary metabolites Transcription factors Ubiquitin Ubiquitin-protein ligase Ubiquitination
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