The 18F-FDG PET/CT response to radiotherapy for patients with spinal metastasis correlated with the clinical outcomes
To evaluate the potential role of 18F-fluorodeoxyglucose-positron emission tomography/computerized tomography (FDG-PET/CT) for predicting treatment response after radiotherapy (RT) in patients with spinal metastases. A retrospective analysis was performed of 42 patients with spinal metastases who re...
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| description | To evaluate the potential role of 18F-fluorodeoxyglucose-positron emission tomography/computerized tomography (FDG-PET/CT) for predicting treatment response after radiotherapy (RT) in patients with spinal metastases.
A retrospective analysis was performed of 42 patients with spinal metastases who received RT from January 2010 to December 2014. All patients underwent FDG-PET/CT before and after treatment. Changes in metabolic responses, expressed as the maximum, mean, peak standardized uptake values (SUVmax, SUVmean, SUVpeak), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were analyzed to determine their association with clinical outcomes.
The median age at the time of spinal metastasis diagnosis was 58 years. Median progression-free survival (PFS) and overall survival after RT were 15 months and 22.4 months, respectively. RT produced a significant decrease in SUVmean (2.27 to 1.41), SUVmax (6.87 to 2.99), SUVpeak (5.75 to 2.33) and TLG (52.84 to 24.17) when compared with the baseline values (p |
| doi_str_mv | 10.1371/journal.pone.0204918 |
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A retrospective analysis was performed of 42 patients with spinal metastases who received RT from January 2010 to December 2014. All patients underwent FDG-PET/CT before and after treatment. Changes in metabolic responses, expressed as the maximum, mean, peak standardized uptake values (SUVmax, SUVmean, SUVpeak), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were analyzed to determine their association with clinical outcomes.
The median age at the time of spinal metastasis diagnosis was 58 years. Median progression-free survival (PFS) and overall survival after RT were 15 months and 22.4 months, respectively. RT produced a significant decrease in SUVmean (2.27 to 1.41), SUVmax (6.87 to 2.99), SUVpeak (5.75 to 2.33) and TLG (52.84 to 24.17) when compared with the baseline values (p<0.001). The mean pain score decreased from 3.86 before RT to 0.79 after RT (p<0.001). There were significant linear relationships between maximum SUV and pain scores at baseline (r = 0.321, p = 0.038) and after treatment (r = 0.369, p = 0.016) as well as TLG at baseline (r = 0.428, p = 0.005) and after treatment (r = 0.403, p = 0.009). Local progression after treatment was identified in 12 patients (28.6%). Univariate analyses showed that >70% reduction in maximum SUV after treatment was independently associated with good PFS (p = 0.036).
RT is an effective treatment for patients with spinal metastases, and there were significant changes in PET parameters compared with baseline. The metabolic response measured by SUV and TLG changes in FDG-PET/CT correlated with the clinical outcomes, especially with shorter PFS in patients who had higher residual maximum SUV after treatment.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0204918</identifier><identifier>PMID: 30265736</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Breast cancer ; Cancer therapies ; Clinical outcomes ; Computed tomography ; Drug dosages ; Emission analysis ; Fluorine isotopes ; Glycolysis ; Hospitals ; Medical imaging ; Medical prognosis ; Medicine and Health Sciences ; Metabolic response ; Metabolism ; Metastases ; Metastasis ; NMR ; Nuclear magnetic resonance ; Nuclear medicine ; Oncology ; Pain ; Patients ; Positron emission ; Positron emission tomography ; Radiation therapy ; Research and Analysis Methods ; Spinal cord ; Survival ; Tomography ; Tumors ; Volumetric analysis</subject><ispartof>PloS one, 2018, Vol.13 (9), p.e0204918-e0204918</ispartof><rights>2018 Choi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Choi et al 2018 Choi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3718-286cc68ea419b9b3771987c2deb48bfb587bb0dc565d7918cc574eea3f061d843</citedby><cites>FETCH-LOGICAL-c3718-286cc68ea419b9b3771987c2deb48bfb587bb0dc565d7918cc574eea3f061d843</cites><orcidid>0000-0001-7165-3373</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161908/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161908/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,4010,23847,27904,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30265736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Woloschak, Gayle E.</contributor><creatorcontrib>Choi, Jinhyun</creatorcontrib><creatorcontrib>Kim, Jun Won</creatorcontrib><creatorcontrib>Jeon, Tae Joo</creatorcontrib><creatorcontrib>Lee, Ik Jae</creatorcontrib><title>The 18F-FDG PET/CT response to radiotherapy for patients with spinal metastasis correlated with the clinical outcomes</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To evaluate the potential role of 18F-fluorodeoxyglucose-positron emission tomography/computerized tomography (FDG-PET/CT) for predicting treatment response after radiotherapy (RT) in patients with spinal metastases.
A retrospective analysis was performed of 42 patients with spinal metastases who received RT from January 2010 to December 2014. All patients underwent FDG-PET/CT before and after treatment. Changes in metabolic responses, expressed as the maximum, mean, peak standardized uptake values (SUVmax, SUVmean, SUVpeak), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were analyzed to determine their association with clinical outcomes.
The median age at the time of spinal metastasis diagnosis was 58 years. Median progression-free survival (PFS) and overall survival after RT were 15 months and 22.4 months, respectively. RT produced a significant decrease in SUVmean (2.27 to 1.41), SUVmax (6.87 to 2.99), SUVpeak (5.75 to 2.33) and TLG (52.84 to 24.17) when compared with the baseline values (p<0.001). The mean pain score decreased from 3.86 before RT to 0.79 after RT (p<0.001). There were significant linear relationships between maximum SUV and pain scores at baseline (r = 0.321, p = 0.038) and after treatment (r = 0.369, p = 0.016) as well as TLG at baseline (r = 0.428, p = 0.005) and after treatment (r = 0.403, p = 0.009). Local progression after treatment was identified in 12 patients (28.6%). Univariate analyses showed that >70% reduction in maximum SUV after treatment was independently associated with good PFS (p = 0.036).
RT is an effective treatment for patients with spinal metastases, and there were significant changes in PET parameters compared with baseline. The metabolic response measured by SUV and TLG changes in FDG-PET/CT correlated with the clinical outcomes, especially with shorter PFS in patients who had higher residual maximum SUV after treatment.</description><subject>Biology and Life Sciences</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Clinical outcomes</subject><subject>Computed tomography</subject><subject>Drug dosages</subject><subject>Emission analysis</subject><subject>Fluorine isotopes</subject><subject>Glycolysis</subject><subject>Hospitals</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Medicine and Health Sciences</subject><subject>Metabolic response</subject><subject>Metabolism</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Nuclear medicine</subject><subject>Oncology</subject><subject>Pain</subject><subject>Patients</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Radiation therapy</subject><subject>Research and Analysis Methods</subject><subject>Spinal cord</subject><subject>Survival</subject><subject>Tomography</subject><subject>Tumors</subject><subject>Volumetric 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18F-FDG PET/CT response to radiotherapy for patients with spinal metastasis correlated with the clinical outcomes</title><author>Choi, Jinhyun ; Kim, Jun Won ; Jeon, Tae Joo ; Lee, Ik Jae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3718-286cc68ea419b9b3771987c2deb48bfb587bb0dc565d7918cc574eea3f061d843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biology and Life Sciences</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Clinical outcomes</topic><topic>Computed tomography</topic><topic>Drug dosages</topic><topic>Emission analysis</topic><topic>Fluorine isotopes</topic><topic>Glycolysis</topic><topic>Hospitals</topic><topic>Medical imaging</topic><topic>Medical prognosis</topic><topic>Medicine and Health Sciences</topic><topic>Metabolic 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Jinhyun</au><au>Kim, Jun Won</au><au>Jeon, Tae Joo</au><au>Lee, Ik Jae</au><au>Woloschak, Gayle E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The 18F-FDG PET/CT response to radiotherapy for patients with spinal metastasis correlated with the clinical outcomes</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018</date><risdate>2018</risdate><volume>13</volume><issue>9</issue><spage>e0204918</spage><epage>e0204918</epage><pages>e0204918-e0204918</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To evaluate the potential role of 18F-fluorodeoxyglucose-positron emission tomography/computerized tomography (FDG-PET/CT) for predicting treatment response after radiotherapy (RT) in patients with spinal metastases.
A retrospective analysis was performed of 42 patients with spinal metastases who received RT from January 2010 to December 2014. All patients underwent FDG-PET/CT before and after treatment. Changes in metabolic responses, expressed as the maximum, mean, peak standardized uptake values (SUVmax, SUVmean, SUVpeak), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were analyzed to determine their association with clinical outcomes.
The median age at the time of spinal metastasis diagnosis was 58 years. Median progression-free survival (PFS) and overall survival after RT were 15 months and 22.4 months, respectively. RT produced a significant decrease in SUVmean (2.27 to 1.41), SUVmax (6.87 to 2.99), SUVpeak (5.75 to 2.33) and TLG (52.84 to 24.17) when compared with the baseline values (p<0.001). The mean pain score decreased from 3.86 before RT to 0.79 after RT (p<0.001). There were significant linear relationships between maximum SUV and pain scores at baseline (r = 0.321, p = 0.038) and after treatment (r = 0.369, p = 0.016) as well as TLG at baseline (r = 0.428, p = 0.005) and after treatment (r = 0.403, p = 0.009). Local progression after treatment was identified in 12 patients (28.6%). Univariate analyses showed that >70% reduction in maximum SUV after treatment was independently associated with good PFS (p = 0.036).
RT is an effective treatment for patients with spinal metastases, and there were significant changes in PET parameters compared with baseline. The metabolic response measured by SUV and TLG changes in FDG-PET/CT correlated with the clinical outcomes, especially with shorter PFS in patients who had higher residual maximum SUV after treatment.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30265736</pmid><doi>10.1371/journal.pone.0204918</doi><orcidid>https://orcid.org/0000-0001-7165-3373</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biology and Life Sciences Breast cancer Cancer therapies Clinical outcomes Computed tomography Drug dosages Emission analysis Fluorine isotopes Glycolysis Hospitals Medical imaging Medical prognosis Medicine and Health Sciences Metabolic response Metabolism Metastases Metastasis NMR Nuclear magnetic resonance Nuclear medicine Oncology Pain Patients Positron emission Positron emission tomography Radiation therapy Research and Analysis Methods Spinal cord Survival Tomography Tumors Volumetric analysis |
| title | The 18F-FDG PET/CT response to radiotherapy for patients with spinal metastasis correlated with the clinical outcomes |
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