Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1)

P-glycoprotein (P-gp) is an ABC transporter that exports many amphipathic or hydrophobic compounds, including chemically and functionally dissimilar anticancer drugs, from cells. To understand the role of transmembrane helices (TMH) 1 and 7 in drug-binding and transport, we selected six residues fro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2018-09, Vol.13 (9), p.e0204693
Hauptverfasser:	Sajid, Andaleeb, Lusvarghi, Sabrina, Chufan, Eduardo E, Ambudkar, Suresh V
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporter Adenosine triphosphatase Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Alanine Amino Acid Sequence Amino Acid Substitution Antibodies Antineoplastic drugs Antitumor agents ATP Binding Cassette Transporter, Subfamily B - chemistry ATP Binding Cassette Transporter, Subfamily B - genetics ATP Binding Cassette Transporter, Subfamily B - metabolism Baculovirus Binding Binding sites Binding Sites - genetics Biochemistry Biological Transport, Active - genetics Biology Biology and Life Sciences Cancer Conformation Cyclosporins Docking Efflux Gene expression Gene mutation Glycoproteins HeLa Cells Helices Homology Humans Hydrophobicity Immunoglobulins Kinetics Laboratories Medical research Membrane proteins Models, Molecular Molecular Docking Simulation Mutagenesis, Site-Directed Mutant Proteins - chemistry Mutant Proteins - genetics Mutant Proteins - metabolism Mutants Mutation Organic chemistry P-Glycoprotein Protein Conformation, alpha-Helical Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Research and analysis methods Residues Structural Homology, Protein Studies Substrate Specificity Substrates Transport
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!