Inspiratory muscle weakness contributes to exertional dyspnea in chronic thromboembolic pulmonary hypertension
Determination of potentially-reversible factors contributing to exertional dyspnea remains an unmet clinical need in chronic thromboembolic pulmonary hypertension (CTEPH). Therefore, we aimed to evaluate the influence of inspiratory muscle weakness (IMW) on exercise capacity and dyspnea during effor...
Gespeichert in:
| Veröffentlicht in: | PloS one 2018-09, Vol.13 (9), p.e0204072-e0204072 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0204072 |
|---|---|
| container_issue | 9 |
| container_start_page | e0204072 |
| container_title | PloS one |
| container_volume | 13 |
| creator | Rolim, João Victor Ota-Arakaki, Jaquelina Sonoe Ferreira, Eloara V M Figliolino, Gabriela A M Ivanaga, Ivan Vieira, Elaine Brito Fonseca, Angelo X C Messina, Carolina M S Costa, Camila Melo Neder, J Alberto Nery, Luiz Eduardo Ramos, Roberta Pulcheri |
| description | Determination of potentially-reversible factors contributing to exertional dyspnea remains an unmet clinical need in chronic thromboembolic pulmonary hypertension (CTEPH). Therefore, we aimed to evaluate the influence of inspiratory muscle weakness (IMW) on exercise capacity and dyspnea during effort in patients with CTEPH. We performed a prospective cross-sectional study that included thirty-nine consecutive patients with CTEPH (48 ± 15 yrs, 61% female) confirmed by right heart catheterization that underwent an incremental cardiopulmonary exercise test, 6-minute walk test and maximum inspiratory pressure (MIP) measurement. MIP < 70%pred was found in 46% of patients. On a multiple linear regression analysis, MIP was independently associated with 6MWD and [Formula: see text]. Patients with MIP < 70% presented greater [Formula: see text] than those with MIP ≥ 70%. Additionally, they also presented stronger sensations of dyspnea throughout exercise, even when adjusted for ventilation. At rest and at different levels of exercise, mean inspiratory flow (VT/TI) was significantly higher in patients with MIP < 70%. In conclusion, IMW is associated with a rapid increase of dyspnea, higher inspiratory load and poor exercise capacity in patients with CTEPH. |
| doi_str_mv | 10.1371/journal.pone.0204072 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2113593816</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A560248402</galeid><doaj_id>oai_doaj_org_article_34c53c2cff2f44028c0764a7c80f397a</doaj_id><sourcerecordid>A560248402</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-1da48671c7daaec6b7d6afa48c821cc80ecd24b6394a96e2ae34d569b89606d23</originalsourceid><addsrcrecordid>eNqNk1uL1DAUx4so7rr6DUQLgujDjLlN2r4Iy-JlYGHB22tI09OZjG1Sk1Z3vr2nO91lKvsgpSQ9_Z3_uSQnSZ5TsqQ8o-92fghON8vOO1gSRgTJ2IPklBacLSQj_OHR_iR5EuOOkBXPpXycnHDCJCkycpq4tYudDbr3YZ-2QzQNpH9A_3QQY2q864Mthx5i2vsUriH01mPQtNrHzoFOrUvNNnhnTdrj2pYe8G3wsxuaFlFU3e479AMX0fVp8qjWTYRn03qWfP_44dvF58Xl1af1xfnlwsiC9QtaaZHLjJqs0hqMLLNK6hptJmfUmJyAqZgoJS-ELiQwDVxUK1mUeSGJrBg_S14edLvGRzW1KipGKV8VPKcSifWBqLzeqS7YFnNVXlt1Y_BhozRWi_1QXJgVN8zUNauFICw3JJNCZ5hHzYtMo9b7KdpQtlAZwLbpZiY6_-PsVm38byWpJIRmKPBmEgj-1wCxV62NBppGO_DDTd5CFoTRsbJX_6D3VzdRG40FWFd7jGtGUXW-koSJHOtAankPhU8FrcXDh9qifebwduYwXhC47jd6iFGtv375f_bqx5x9fcRuQTf9NvpmGG9bnIPiAJrgYwxQ3zWZEjWOxW031DgWahoLdHtxfEB3TrdzwP8CgCcKcA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2113593816</pqid></control><display><type>article</type><title>Inspiratory muscle weakness contributes to exertional dyspnea in chronic thromboembolic pulmonary hypertension</title><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Rolim, João Victor ; Ota-Arakaki, Jaquelina Sonoe ; Ferreira, Eloara V M ; Figliolino, Gabriela A M ; Ivanaga, Ivan ; Vieira, Elaine Brito ; Fonseca, Angelo X C ; Messina, Carolina M S ; Costa, Camila Melo ; Neder, J Alberto ; Nery, Luiz Eduardo ; Ramos, Roberta Pulcheri</creator><contributor>Passino, Claudio</contributor><creatorcontrib>Rolim, João Victor ; Ota-Arakaki, Jaquelina Sonoe ; Ferreira, Eloara V M ; Figliolino, Gabriela A M ; Ivanaga, Ivan ; Vieira, Elaine Brito ; Fonseca, Angelo X C ; Messina, Carolina M S ; Costa, Camila Melo ; Neder, J Alberto ; Nery, Luiz Eduardo ; Ramos, Roberta Pulcheri ; Passino, Claudio</creatorcontrib><description>Determination of potentially-reversible factors contributing to exertional dyspnea remains an unmet clinical need in chronic thromboembolic pulmonary hypertension (CTEPH). Therefore, we aimed to evaluate the influence of inspiratory muscle weakness (IMW) on exercise capacity and dyspnea during effort in patients with CTEPH. We performed a prospective cross-sectional study that included thirty-nine consecutive patients with CTEPH (48 ± 15 yrs, 61% female) confirmed by right heart catheterization that underwent an incremental cardiopulmonary exercise test, 6-minute walk test and maximum inspiratory pressure (MIP) measurement. MIP < 70%pred was found in 46% of patients. On a multiple linear regression analysis, MIP was independently associated with 6MWD and [Formula: see text]. Patients with MIP < 70% presented greater [Formula: see text] than those with MIP ≥ 70%. Additionally, they also presented stronger sensations of dyspnea throughout exercise, even when adjusted for ventilation. At rest and at different levels of exercise, mean inspiratory flow (VT/TI) was significantly higher in patients with MIP < 70%. In conclusion, IMW is associated with a rapid increase of dyspnea, higher inspiratory load and poor exercise capacity in patients with CTEPH.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0204072</identifier><identifier>PMID: 30260970</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Catheterization ; Dyspnea ; Ergometry ; Exercise ; Exercise physiology ; Heart ; Hypertension ; Influence ; Laboratories ; Medical diagnosis ; Medical prognosis ; Medicine ; Medicine and Health Sciences ; Muscle weakness ; Muscles ; Patients ; Pulmonary arteries ; Pulmonary embolisms ; Pulmonary hypertension ; Regression analysis ; Respiration ; Respiratory diseases ; Thromboembolism ; Ventilation ; Ventilators</subject><ispartof>PloS one, 2018-09, Vol.13 (9), p.e0204072-e0204072</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Rolim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Rolim et al 2018 Rolim et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-1da48671c7daaec6b7d6afa48c821cc80ecd24b6394a96e2ae34d569b89606d23</citedby><cites>FETCH-LOGICAL-c692t-1da48671c7daaec6b7d6afa48c821cc80ecd24b6394a96e2ae34d569b89606d23</cites><orcidid>0000-0002-5350-7679</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160017/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160017/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30260970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Passino, Claudio</contributor><creatorcontrib>Rolim, João Victor</creatorcontrib><creatorcontrib>Ota-Arakaki, Jaquelina Sonoe</creatorcontrib><creatorcontrib>Ferreira, Eloara V M</creatorcontrib><creatorcontrib>Figliolino, Gabriela A M</creatorcontrib><creatorcontrib>Ivanaga, Ivan</creatorcontrib><creatorcontrib>Vieira, Elaine Brito</creatorcontrib><creatorcontrib>Fonseca, Angelo X C</creatorcontrib><creatorcontrib>Messina, Carolina M S</creatorcontrib><creatorcontrib>Costa, Camila Melo</creatorcontrib><creatorcontrib>Neder, J Alberto</creatorcontrib><creatorcontrib>Nery, Luiz Eduardo</creatorcontrib><creatorcontrib>Ramos, Roberta Pulcheri</creatorcontrib><title>Inspiratory muscle weakness contributes to exertional dyspnea in chronic thromboembolic pulmonary hypertension</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Determination of potentially-reversible factors contributing to exertional dyspnea remains an unmet clinical need in chronic thromboembolic pulmonary hypertension (CTEPH). Therefore, we aimed to evaluate the influence of inspiratory muscle weakness (IMW) on exercise capacity and dyspnea during effort in patients with CTEPH. We performed a prospective cross-sectional study that included thirty-nine consecutive patients with CTEPH (48 ± 15 yrs, 61% female) confirmed by right heart catheterization that underwent an incremental cardiopulmonary exercise test, 6-minute walk test and maximum inspiratory pressure (MIP) measurement. MIP < 70%pred was found in 46% of patients. On a multiple linear regression analysis, MIP was independently associated with 6MWD and [Formula: see text]. Patients with MIP < 70% presented greater [Formula: see text] than those with MIP ≥ 70%. Additionally, they also presented stronger sensations of dyspnea throughout exercise, even when adjusted for ventilation. At rest and at different levels of exercise, mean inspiratory flow (VT/TI) was significantly higher in patients with MIP < 70%. In conclusion, IMW is associated with a rapid increase of dyspnea, higher inspiratory load and poor exercise capacity in patients with CTEPH.</description><subject>Biology and Life Sciences</subject><subject>Catheterization</subject><subject>Dyspnea</subject><subject>Ergometry</subject><subject>Exercise</subject><subject>Exercise physiology</subject><subject>Heart</subject><subject>Hypertension</subject><subject>Influence</subject><subject>Laboratories</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Muscle weakness</subject><subject>Muscles</subject><subject>Patients</subject><subject>Pulmonary arteries</subject><subject>Pulmonary embolisms</subject><subject>Pulmonary hypertension</subject><subject>Regression analysis</subject><subject>Respiration</subject><subject>Respiratory diseases</subject><subject>Thromboembolism</subject><subject>Ventilation</subject><subject>Ventilators</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1uL1DAUx4so7rr6DUQLgujDjLlN2r4Iy-JlYGHB22tI09OZjG1Sk1Z3vr2nO91lKvsgpSQ9_Z3_uSQnSZ5TsqQ8o-92fghON8vOO1gSRgTJ2IPklBacLSQj_OHR_iR5EuOOkBXPpXycnHDCJCkycpq4tYudDbr3YZ-2QzQNpH9A_3QQY2q864Mthx5i2vsUriH01mPQtNrHzoFOrUvNNnhnTdrj2pYe8G3wsxuaFlFU3e479AMX0fVp8qjWTYRn03qWfP_44dvF58Xl1af1xfnlwsiC9QtaaZHLjJqs0hqMLLNK6hptJmfUmJyAqZgoJS-ELiQwDVxUK1mUeSGJrBg_S14edLvGRzW1KipGKV8VPKcSifWBqLzeqS7YFnNVXlt1Y_BhozRWi_1QXJgVN8zUNauFICw3JJNCZ5hHzYtMo9b7KdpQtlAZwLbpZiY6_-PsVm38byWpJIRmKPBmEgj-1wCxV62NBppGO_DDTd5CFoTRsbJX_6D3VzdRG40FWFd7jGtGUXW-koSJHOtAankPhU8FrcXDh9qifebwduYwXhC47jd6iFGtv375f_bqx5x9fcRuQTf9NvpmGG9bnIPiAJrgYwxQ3zWZEjWOxW031DgWahoLdHtxfEB3TrdzwP8CgCcKcA</recordid><startdate>20180927</startdate><enddate>20180927</enddate><creator>Rolim, João Victor</creator><creator>Ota-Arakaki, Jaquelina Sonoe</creator><creator>Ferreira, Eloara V M</creator><creator>Figliolino, Gabriela A M</creator><creator>Ivanaga, Ivan</creator><creator>Vieira, Elaine Brito</creator><creator>Fonseca, Angelo X C</creator><creator>Messina, Carolina M S</creator><creator>Costa, Camila Melo</creator><creator>Neder, J Alberto</creator><creator>Nery, Luiz Eduardo</creator><creator>Ramos, Roberta Pulcheri</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5350-7679</orcidid></search><sort><creationdate>20180927</creationdate><title>Inspiratory muscle weakness contributes to exertional dyspnea in chronic thromboembolic pulmonary hypertension</title><author>Rolim, João Victor ; Ota-Arakaki, Jaquelina Sonoe ; Ferreira, Eloara V M ; Figliolino, Gabriela A M ; Ivanaga, Ivan ; Vieira, Elaine Brito ; Fonseca, Angelo X C ; Messina, Carolina M S ; Costa, Camila Melo ; Neder, J Alberto ; Nery, Luiz Eduardo ; Ramos, Roberta Pulcheri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-1da48671c7daaec6b7d6afa48c821cc80ecd24b6394a96e2ae34d569b89606d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biology and Life Sciences</topic><topic>Catheterization</topic><topic>Dyspnea</topic><topic>Ergometry</topic><topic>Exercise</topic><topic>Exercise physiology</topic><topic>Heart</topic><topic>Hypertension</topic><topic>Influence</topic><topic>Laboratories</topic><topic>Medical diagnosis</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Muscle weakness</topic><topic>Muscles</topic><topic>Patients</topic><topic>Pulmonary arteries</topic><topic>Pulmonary embolisms</topic><topic>Pulmonary hypertension</topic><topic>Regression analysis</topic><topic>Respiration</topic><topic>Respiratory diseases</topic><topic>Thromboembolism</topic><topic>Ventilation</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rolim, João Victor</creatorcontrib><creatorcontrib>Ota-Arakaki, Jaquelina Sonoe</creatorcontrib><creatorcontrib>Ferreira, Eloara V M</creatorcontrib><creatorcontrib>Figliolino, Gabriela A M</creatorcontrib><creatorcontrib>Ivanaga, Ivan</creatorcontrib><creatorcontrib>Vieira, Elaine Brito</creatorcontrib><creatorcontrib>Fonseca, Angelo X C</creatorcontrib><creatorcontrib>Messina, Carolina M S</creatorcontrib><creatorcontrib>Costa, Camila Melo</creatorcontrib><creatorcontrib>Neder, J Alberto</creatorcontrib><creatorcontrib>Nery, Luiz Eduardo</creatorcontrib><creatorcontrib>Ramos, Roberta Pulcheri</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rolim, João Victor</au><au>Ota-Arakaki, Jaquelina Sonoe</au><au>Ferreira, Eloara V M</au><au>Figliolino, Gabriela A M</au><au>Ivanaga, Ivan</au><au>Vieira, Elaine Brito</au><au>Fonseca, Angelo X C</au><au>Messina, Carolina M S</au><au>Costa, Camila Melo</au><au>Neder, J Alberto</au><au>Nery, Luiz Eduardo</au><au>Ramos, Roberta Pulcheri</au><au>Passino, Claudio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inspiratory muscle weakness contributes to exertional dyspnea in chronic thromboembolic pulmonary hypertension</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-09-27</date><risdate>2018</risdate><volume>13</volume><issue>9</issue><spage>e0204072</spage><epage>e0204072</epage><pages>e0204072-e0204072</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Determination of potentially-reversible factors contributing to exertional dyspnea remains an unmet clinical need in chronic thromboembolic pulmonary hypertension (CTEPH). Therefore, we aimed to evaluate the influence of inspiratory muscle weakness (IMW) on exercise capacity and dyspnea during effort in patients with CTEPH. We performed a prospective cross-sectional study that included thirty-nine consecutive patients with CTEPH (48 ± 15 yrs, 61% female) confirmed by right heart catheterization that underwent an incremental cardiopulmonary exercise test, 6-minute walk test and maximum inspiratory pressure (MIP) measurement. MIP < 70%pred was found in 46% of patients. On a multiple linear regression analysis, MIP was independently associated with 6MWD and [Formula: see text]. Patients with MIP < 70% presented greater [Formula: see text] than those with MIP ≥ 70%. Additionally, they also presented stronger sensations of dyspnea throughout exercise, even when adjusted for ventilation. At rest and at different levels of exercise, mean inspiratory flow (VT/TI) was significantly higher in patients with MIP < 70%. In conclusion, IMW is associated with a rapid increase of dyspnea, higher inspiratory load and poor exercise capacity in patients with CTEPH.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30260970</pmid><doi>10.1371/journal.pone.0204072</doi><tpages>e0204072</tpages><orcidid>https://orcid.org/0000-0002-5350-7679</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2018-09, Vol.13 (9), p.e0204072-e0204072 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2113593816 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Biology and Life Sciences Catheterization Dyspnea Ergometry Exercise Exercise physiology Heart Hypertension Influence Laboratories Medical diagnosis Medical prognosis Medicine Medicine and Health Sciences Muscle weakness Muscles Patients Pulmonary arteries Pulmonary embolisms Pulmonary hypertension Regression analysis Respiration Respiratory diseases Thromboembolism Ventilation Ventilators |
| title | Inspiratory muscle weakness contributes to exertional dyspnea in chronic thromboembolic pulmonary hypertension |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T20%3A38%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inspiratory%20muscle%20weakness%20contributes%20to%20exertional%20dyspnea%20in%20chronic%20thromboembolic%20pulmonary%20hypertension&rft.jtitle=PloS%20one&rft.au=Rolim,%20Jo%C3%A3o%20Victor&rft.date=2018-09-27&rft.volume=13&rft.issue=9&rft.spage=e0204072&rft.epage=e0204072&rft.pages=e0204072-e0204072&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0204072&rft_dat=%3Cgale_plos_%3EA560248402%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2113593816&rft_id=info:pmid/30260970&rft_galeid=A560248402&rft_doaj_id=oai_doaj_org_article_34c53c2cff2f44028c0764a7c80f397a&rfr_iscdi=true |