Dimerization misalignment in human glutamate-oxaloacetate transaminase variants is the primary factor for PLP release

The active form of vitamin B6, pyridoxal 5'-phosphate (PLP), plays an essential role in the catalytic mechanism of various proteins, including human glutamate-oxaloacetate transaminase (hGOT1), an important enzyme in amino acid metabolism. A recent molecular and genetic study showed that the E2...

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Veröffentlicht in:	PloS one 2018-09, Vol.13 (9), p.e0203889-e0203889
Hauptverfasser:	Lee, Jesi, Gokey, Trevor, Ting, Dylan, He, Zheng-Hui, Guliaev, Anton B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Affinity Amino acids Analysis Arabidopsis Arabidopsis thaliana Aspartate aminotransferase Binding sites Biochemistry Biology and Life Sciences Catalysis Chemistry Computer applications Computer simulation Dimerization Dimers Dissociation Enzymes Homeostasis Hydrogen Hydrogen bonds Imines Medicine and Health Sciences Metabolic pathways Metabolism Misalignment Molecular dynamics Phosphates Physical Sciences Physiological aspects Principal components analysis Proteins Research and Analysis Methods Schiff bases Stability analysis Substrates Transaminase Vitamin B6
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