Continued occurrence of serotype 1 pneumococcal meningitis in two regions located in the meningitis belt in Ghana five years after introduction of 13-valent pneumococcal conjugate vaccine
Increases in pneumococcal meningitis were reported from Ghanaian regions that lie in the meningitis belt in 2016-2017, despite introduction of 13-valent pneumococcal conjugate vaccine (PCV13) in 2012 using a 3-dose schedule (6, 10, and 14 weeks). We describe pneumococcal meningitis epidemiology in t...
Gespeichert in:
| Veröffentlicht in: | PloS one 2018-09, Vol.13 (9), p.e0203205-e0203205 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0203205 |
|---|---|
| container_issue | 9 |
| container_start_page | e0203205 |
| container_title | PloS one |
| container_volume | 13 |
| creator | Bozio, Catherine H Abdul-Karim, Abass Abenyeri, John Abubakari, Braimah Ofosu, Winfred Zoya, Justina Ouattara, Mahamoudou Srinivasan, Velusamy Vuong, Jeni T Opare, David Asiedu-Bekoe, Franklin Lessa, Fernanda C |
| description | Increases in pneumococcal meningitis were reported from Ghanaian regions that lie in the meningitis belt in 2016-2017, despite introduction of 13-valent pneumococcal conjugate vaccine (PCV13) in 2012 using a 3-dose schedule (6, 10, and 14 weeks). We describe pneumococcal meningitis epidemiology in the Ghanaian Northern and Upper West regions across two meningitis seasons.
Suspected meningitis cases were identified using World Health Organization standard definitions. Pneumococcal meningitis was confirmed if pneumococcus was the sole pathogen detected by polymerase chain reaction, culture, or latex agglutination in cerebrospinal fluid collected from a person with suspected meningitis during December 2015-March 2017. Pneumococcal serotyping was done using PCR. Annual age-specific pneumococcal meningitis incidence (cases per 100,000 population) was calculated, adjusting for suspected meningitis cases lacking confirmatory testing.
Among 153 pneumococcal meningitis cases, 137 (89.5%) were serotyped; 100 (73.0%) were PCV13-type, including 85 (62.0%) that were serotype 1, a PCV13-targeted serotype. Persons aged ≥5 years accounted for 96.7% (148/153) of cases. Comparing 2015-2016 and 2016-2017 seasons, the proportion of non-serotype 1 PCV13-type cases decreased from 20.0% (9/45) to 4.1% (3/74) (p = 0.008), whereas the proportion that was serotype 1 was stable (71.1% (32/45) vs. 58.1% (43/74); p = 0.16). Estimated adjusted pneumococcal meningitis incidence was 1.8 in children aged |
| doi_str_mv | 10.1371/journal.pone.0203205 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2100862093</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A557791776</galeid><doaj_id>oai_doaj_org_article_a44b338b589b48e3bf30498bb572e83f</doaj_id><sourcerecordid>A557791776</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-75873ddeff52c69dae70f4da63d5a45b7923779f0aee83f7207406d6a9ef1c263</originalsourceid><addsrcrecordid>eNqNk9tu1DAQhiMEoqXwBggsISG42MWHJE5ukKoKSqVKlTjdWo4zznrltRfbWeiz8XI47bbaIC5QLpLMfPOP80-mKJ4TvCSMk3drPwYn7XLrHSwxxYzi6kFxTFpGF3V-fXjwfFQ8iXGNccWaun5cHDFMWso5PS5-n3mXjBuhR16pMQRwCpDXKELw6XoLiKCtg3HjVc5LizbgjBtMMhEZh9JPjwIMxruIrFcyZZ0pvIJDsAObpvD5SjqJtNkBugYZIpI6QciZFHw_qpRlptaELXbSgkvzzsq79TjkFmgnlTIOnhaPtLQRnu3vJ8W3jx--nn1aXF6dX5ydXi5U3dK04FXDWd-D1hXNkV4Cx7rsZc36SpZVx1vKOG81lgAN05xiXuK6r2ULmihas5Pi5a3u1voo9r5HQQnGTXa3ZZm4uCV6L9diG8xGhmvhpRE3AR8GIUMyyoKQZdkx1nRV03ZlA6zTDJdt03UVp1P7rPV-323sNtCr7EOQdiY6zzizEoPfiZrQpmI8C7zZCwT_Y4SYxMZEBdZKB368OTehNW_L6dyv_kL__XV7ashTEcZpn_uqSVScVlW2jnA-ubT8B5WvHjYmzw60yfFZwdtZQWYS_EqDHGMUF18-_z979X3Ovj5gVyBtWkVvx-n3inOwvAVV8DEG0PcmEyymHbtzQ0w7JvY7lsteHA7ovuhuqdgfWY8leg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2100862093</pqid></control><display><type>article</type><title>Continued occurrence of serotype 1 pneumococcal meningitis in two regions located in the meningitis belt in Ghana five years after introduction of 13-valent pneumococcal conjugate vaccine</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Bozio, Catherine H ; Abdul-Karim, Abass ; Abenyeri, John ; Abubakari, Braimah ; Ofosu, Winfred ; Zoya, Justina ; Ouattara, Mahamoudou ; Srinivasan, Velusamy ; Vuong, Jeni T ; Opare, David ; Asiedu-Bekoe, Franklin ; Lessa, Fernanda C</creator><contributor>Melo-Cristino, Jose</contributor><creatorcontrib>Bozio, Catherine H ; Abdul-Karim, Abass ; Abenyeri, John ; Abubakari, Braimah ; Ofosu, Winfred ; Zoya, Justina ; Ouattara, Mahamoudou ; Srinivasan, Velusamy ; Vuong, Jeni T ; Opare, David ; Asiedu-Bekoe, Franklin ; Lessa, Fernanda C ; Melo-Cristino, Jose</creatorcontrib><description>Increases in pneumococcal meningitis were reported from Ghanaian regions that lie in the meningitis belt in 2016-2017, despite introduction of 13-valent pneumococcal conjugate vaccine (PCV13) in 2012 using a 3-dose schedule (6, 10, and 14 weeks). We describe pneumococcal meningitis epidemiology in the Ghanaian Northern and Upper West regions across two meningitis seasons.
Suspected meningitis cases were identified using World Health Organization standard definitions. Pneumococcal meningitis was confirmed if pneumococcus was the sole pathogen detected by polymerase chain reaction, culture, or latex agglutination in cerebrospinal fluid collected from a person with suspected meningitis during December 2015-March 2017. Pneumococcal serotyping was done using PCR. Annual age-specific pneumococcal meningitis incidence (cases per 100,000 population) was calculated, adjusting for suspected meningitis cases lacking confirmatory testing.
Among 153 pneumococcal meningitis cases, 137 (89.5%) were serotyped; 100 (73.0%) were PCV13-type, including 85 (62.0%) that were serotype 1, a PCV13-targeted serotype. Persons aged ≥5 years accounted for 96.7% (148/153) of cases. Comparing 2015-2016 and 2016-2017 seasons, the proportion of non-serotype 1 PCV13-type cases decreased from 20.0% (9/45) to 4.1% (3/74) (p = 0.008), whereas the proportion that was serotype 1 was stable (71.1% (32/45) vs. 58.1% (43/74); p = 0.16). Estimated adjusted pneumococcal meningitis incidence was 1.8 in children aged <5 years and ranged from 6.8-10.5 in older children and adults.
High pneumococcal meningitis incidence with a large proportion of serotype 1 disease in older children and adults suggests infant PCV13 vaccination has not induced herd protection with this schedule in this high-transmission setting.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0203205</identifier><identifier>PMID: 30192772</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adults ; Age ; Agglutination ; Analysis ; Bacterial meningitis ; Biology and Life Sciences ; Cerebrospinal fluid ; Children ; Conjugates ; Epidemics ; Epidemiology ; Identification methods ; Immunization ; Incidence ; Laboratories ; Latex ; Latex agglutination ; Medicine and Health Sciences ; Meningitis ; People and Places ; Pneumococcal vaccines ; Polymerase chain reaction ; Prevention ; Research and Analysis Methods ; Serotyping ; Vaccination ; Vaccines</subject><ispartof>PloS one, 2018-09, Vol.13 (9), p.e0203205-e0203205</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-75873ddeff52c69dae70f4da63d5a45b7923779f0aee83f7207406d6a9ef1c263</citedby><cites>FETCH-LOGICAL-c692t-75873ddeff52c69dae70f4da63d5a45b7923779f0aee83f7207406d6a9ef1c263</cites><orcidid>0000-0002-0691-5020 ; 0000-0003-1421-5849 ; 0000-0001-6566-7138</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128537/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128537/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2932,23875,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30192772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Melo-Cristino, Jose</contributor><creatorcontrib>Bozio, Catherine H</creatorcontrib><creatorcontrib>Abdul-Karim, Abass</creatorcontrib><creatorcontrib>Abenyeri, John</creatorcontrib><creatorcontrib>Abubakari, Braimah</creatorcontrib><creatorcontrib>Ofosu, Winfred</creatorcontrib><creatorcontrib>Zoya, Justina</creatorcontrib><creatorcontrib>Ouattara, Mahamoudou</creatorcontrib><creatorcontrib>Srinivasan, Velusamy</creatorcontrib><creatorcontrib>Vuong, Jeni T</creatorcontrib><creatorcontrib>Opare, David</creatorcontrib><creatorcontrib>Asiedu-Bekoe, Franklin</creatorcontrib><creatorcontrib>Lessa, Fernanda C</creatorcontrib><title>Continued occurrence of serotype 1 pneumococcal meningitis in two regions located in the meningitis belt in Ghana five years after introduction of 13-valent pneumococcal conjugate vaccine</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Increases in pneumococcal meningitis were reported from Ghanaian regions that lie in the meningitis belt in 2016-2017, despite introduction of 13-valent pneumococcal conjugate vaccine (PCV13) in 2012 using a 3-dose schedule (6, 10, and 14 weeks). We describe pneumococcal meningitis epidemiology in the Ghanaian Northern and Upper West regions across two meningitis seasons.
Suspected meningitis cases were identified using World Health Organization standard definitions. Pneumococcal meningitis was confirmed if pneumococcus was the sole pathogen detected by polymerase chain reaction, culture, or latex agglutination in cerebrospinal fluid collected from a person with suspected meningitis during December 2015-March 2017. Pneumococcal serotyping was done using PCR. Annual age-specific pneumococcal meningitis incidence (cases per 100,000 population) was calculated, adjusting for suspected meningitis cases lacking confirmatory testing.
Among 153 pneumococcal meningitis cases, 137 (89.5%) were serotyped; 100 (73.0%) were PCV13-type, including 85 (62.0%) that were serotype 1, a PCV13-targeted serotype. Persons aged ≥5 years accounted for 96.7% (148/153) of cases. Comparing 2015-2016 and 2016-2017 seasons, the proportion of non-serotype 1 PCV13-type cases decreased from 20.0% (9/45) to 4.1% (3/74) (p = 0.008), whereas the proportion that was serotype 1 was stable (71.1% (32/45) vs. 58.1% (43/74); p = 0.16). Estimated adjusted pneumococcal meningitis incidence was 1.8 in children aged <5 years and ranged from 6.8-10.5 in older children and adults.
High pneumococcal meningitis incidence with a large proportion of serotype 1 disease in older children and adults suggests infant PCV13 vaccination has not induced herd protection with this schedule in this high-transmission setting.</description><subject>Adults</subject><subject>Age</subject><subject>Agglutination</subject><subject>Analysis</subject><subject>Bacterial meningitis</subject><subject>Biology and Life Sciences</subject><subject>Cerebrospinal fluid</subject><subject>Children</subject><subject>Conjugates</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Identification methods</subject><subject>Immunization</subject><subject>Incidence</subject><subject>Laboratories</subject><subject>Latex</subject><subject>Latex agglutination</subject><subject>Medicine and Health Sciences</subject><subject>Meningitis</subject><subject>People and Places</subject><subject>Pneumococcal vaccines</subject><subject>Polymerase chain reaction</subject><subject>Prevention</subject><subject>Research and Analysis Methods</subject><subject>Serotyping</subject><subject>Vaccination</subject><subject>Vaccines</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEoqXwBggsISG42MWHJE5ukKoKSqVKlTjdWo4zznrltRfbWeiz8XI47bbaIC5QLpLMfPOP80-mKJ4TvCSMk3drPwYn7XLrHSwxxYzi6kFxTFpGF3V-fXjwfFQ8iXGNccWaun5cHDFMWso5PS5-n3mXjBuhR16pMQRwCpDXKELw6XoLiKCtg3HjVc5LizbgjBtMMhEZh9JPjwIMxruIrFcyZZ0pvIJDsAObpvD5SjqJtNkBugYZIpI6QciZFHw_qpRlptaELXbSgkvzzsq79TjkFmgnlTIOnhaPtLQRnu3vJ8W3jx--nn1aXF6dX5ydXi5U3dK04FXDWd-D1hXNkV4Cx7rsZc36SpZVx1vKOG81lgAN05xiXuK6r2ULmihas5Pi5a3u1voo9r5HQQnGTXa3ZZm4uCV6L9diG8xGhmvhpRE3AR8GIUMyyoKQZdkx1nRV03ZlA6zTDJdt03UVp1P7rPV-323sNtCr7EOQdiY6zzizEoPfiZrQpmI8C7zZCwT_Y4SYxMZEBdZKB368OTehNW_L6dyv_kL__XV7ashTEcZpn_uqSVScVlW2jnA-ubT8B5WvHjYmzw60yfFZwdtZQWYS_EqDHGMUF18-_z979X3Ovj5gVyBtWkVvx-n3inOwvAVV8DEG0PcmEyymHbtzQ0w7JvY7lsteHA7ovuhuqdgfWY8leg</recordid><startdate>20180907</startdate><enddate>20180907</enddate><creator>Bozio, Catherine H</creator><creator>Abdul-Karim, Abass</creator><creator>Abenyeri, John</creator><creator>Abubakari, Braimah</creator><creator>Ofosu, Winfred</creator><creator>Zoya, Justina</creator><creator>Ouattara, Mahamoudou</creator><creator>Srinivasan, Velusamy</creator><creator>Vuong, Jeni T</creator><creator>Opare, David</creator><creator>Asiedu-Bekoe, Franklin</creator><creator>Lessa, Fernanda C</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-0691-5020</orcidid><orcidid>https://orcid.org/0000-0003-1421-5849</orcidid><orcidid>https://orcid.org/0000-0001-6566-7138</orcidid></search><sort><creationdate>20180907</creationdate><title>Continued occurrence of serotype 1 pneumococcal meningitis in two regions located in the meningitis belt in Ghana five years after introduction of 13-valent pneumococcal conjugate vaccine</title><author>Bozio, Catherine H ; Abdul-Karim, Abass ; Abenyeri, John ; Abubakari, Braimah ; Ofosu, Winfred ; Zoya, Justina ; Ouattara, Mahamoudou ; Srinivasan, Velusamy ; Vuong, Jeni T ; Opare, David ; Asiedu-Bekoe, Franklin ; Lessa, Fernanda C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-75873ddeff52c69dae70f4da63d5a45b7923779f0aee83f7207406d6a9ef1c263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adults</topic><topic>Age</topic><topic>Agglutination</topic><topic>Analysis</topic><topic>Bacterial meningitis</topic><topic>Biology and Life Sciences</topic><topic>Cerebrospinal fluid</topic><topic>Children</topic><topic>Conjugates</topic><topic>Epidemics</topic><topic>Epidemiology</topic><topic>Identification methods</topic><topic>Immunization</topic><topic>Incidence</topic><topic>Laboratories</topic><topic>Latex</topic><topic>Latex agglutination</topic><topic>Medicine and Health Sciences</topic><topic>Meningitis</topic><topic>People and Places</topic><topic>Pneumococcal vaccines</topic><topic>Polymerase chain reaction</topic><topic>Prevention</topic><topic>Research and Analysis Methods</topic><topic>Serotyping</topic><topic>Vaccination</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bozio, Catherine H</creatorcontrib><creatorcontrib>Abdul-Karim, Abass</creatorcontrib><creatorcontrib>Abenyeri, John</creatorcontrib><creatorcontrib>Abubakari, Braimah</creatorcontrib><creatorcontrib>Ofosu, Winfred</creatorcontrib><creatorcontrib>Zoya, Justina</creatorcontrib><creatorcontrib>Ouattara, Mahamoudou</creatorcontrib><creatorcontrib>Srinivasan, Velusamy</creatorcontrib><creatorcontrib>Vuong, Jeni T</creatorcontrib><creatorcontrib>Opare, David</creatorcontrib><creatorcontrib>Asiedu-Bekoe, Franklin</creatorcontrib><creatorcontrib>Lessa, Fernanda C</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bozio, Catherine H</au><au>Abdul-Karim, Abass</au><au>Abenyeri, John</au><au>Abubakari, Braimah</au><au>Ofosu, Winfred</au><au>Zoya, Justina</au><au>Ouattara, Mahamoudou</au><au>Srinivasan, Velusamy</au><au>Vuong, Jeni T</au><au>Opare, David</au><au>Asiedu-Bekoe, Franklin</au><au>Lessa, Fernanda C</au><au>Melo-Cristino, Jose</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Continued occurrence of serotype 1 pneumococcal meningitis in two regions located in the meningitis belt in Ghana five years after introduction of 13-valent pneumococcal conjugate vaccine</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-09-07</date><risdate>2018</risdate><volume>13</volume><issue>9</issue><spage>e0203205</spage><epage>e0203205</epage><pages>e0203205-e0203205</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Increases in pneumococcal meningitis were reported from Ghanaian regions that lie in the meningitis belt in 2016-2017, despite introduction of 13-valent pneumococcal conjugate vaccine (PCV13) in 2012 using a 3-dose schedule (6, 10, and 14 weeks). We describe pneumococcal meningitis epidemiology in the Ghanaian Northern and Upper West regions across two meningitis seasons.
Suspected meningitis cases were identified using World Health Organization standard definitions. Pneumococcal meningitis was confirmed if pneumococcus was the sole pathogen detected by polymerase chain reaction, culture, or latex agglutination in cerebrospinal fluid collected from a person with suspected meningitis during December 2015-March 2017. Pneumococcal serotyping was done using PCR. Annual age-specific pneumococcal meningitis incidence (cases per 100,000 population) was calculated, adjusting for suspected meningitis cases lacking confirmatory testing.
Among 153 pneumococcal meningitis cases, 137 (89.5%) were serotyped; 100 (73.0%) were PCV13-type, including 85 (62.0%) that were serotype 1, a PCV13-targeted serotype. Persons aged ≥5 years accounted for 96.7% (148/153) of cases. Comparing 2015-2016 and 2016-2017 seasons, the proportion of non-serotype 1 PCV13-type cases decreased from 20.0% (9/45) to 4.1% (3/74) (p = 0.008), whereas the proportion that was serotype 1 was stable (71.1% (32/45) vs. 58.1% (43/74); p = 0.16). Estimated adjusted pneumococcal meningitis incidence was 1.8 in children aged <5 years and ranged from 6.8-10.5 in older children and adults.
High pneumococcal meningitis incidence with a large proportion of serotype 1 disease in older children and adults suggests infant PCV13 vaccination has not induced herd protection with this schedule in this high-transmission setting.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30192772</pmid><doi>10.1371/journal.pone.0203205</doi><tpages>e0203205</tpages><orcidid>https://orcid.org/0000-0002-0691-5020</orcidid><orcidid>https://orcid.org/0000-0003-1421-5849</orcidid><orcidid>https://orcid.org/0000-0001-6566-7138</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2018-09, Vol.13 (9), p.e0203205-e0203205 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2100862093 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adults Age Agglutination Analysis Bacterial meningitis Biology and Life Sciences Cerebrospinal fluid Children Conjugates Epidemics Epidemiology Identification methods Immunization Incidence Laboratories Latex Latex agglutination Medicine and Health Sciences Meningitis People and Places Pneumococcal vaccines Polymerase chain reaction Prevention Research and Analysis Methods Serotyping Vaccination Vaccines |
| title | Continued occurrence of serotype 1 pneumococcal meningitis in two regions located in the meningitis belt in Ghana five years after introduction of 13-valent pneumococcal conjugate vaccine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-02T03%3A27%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Continued%20occurrence%20of%20serotype%201%20pneumococcal%20meningitis%20in%20two%20regions%20located%20in%20the%20meningitis%20belt%20in%20Ghana%20five%20years%20after%20introduction%20of%2013-valent%20pneumococcal%20conjugate%20vaccine&rft.jtitle=PloS%20one&rft.au=Bozio,%20Catherine%20H&rft.date=2018-09-07&rft.volume=13&rft.issue=9&rft.spage=e0203205&rft.epage=e0203205&rft.pages=e0203205-e0203205&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0203205&rft_dat=%3Cgale_plos_%3EA557791776%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2100862093&rft_id=info:pmid/30192772&rft_galeid=A557791776&rft_doaj_id=oai_doaj_org_article_a44b338b589b48e3bf30498bb572e83f&rfr_iscdi=true |