Prognostic utility of serum free light chain ratios and heavy-light chain ratios in multiple myeloma in three PETHEMA/GEM phase III clinical trials

We investigated the prognostic impact and clinical utility of serum free light chains (sFLC) and serum heavy-light chains (sHLC) in patients with multiple myeloma treated according to the GEM2005MENOS65, GEM2005MAS65, and GEM2010MAS65 PETHEMA/GEM phase III clinical trials. Serum samples collected at...

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Veröffentlicht in:	PloS one 2018-09, Vol.13 (9), p.e0203392-e0203392
Hauptverfasser:	Lopez-Anglada, Lucia, Cueto-Felgueroso, Cecilia, Rosiñol, Laura, Oriol, Albert, Teruel, Ana Isabel, Lopez de la Guia, Ana, Bengoechea, Enrique, Palomera, Luis, de Arriba, Felipe, Hernandez, Jose Mariano, Granell, Miquel, Peñalver, Francisco Javier, Garcia-Sanz, Ramon, Besalduch, Juan, Gonzalez, Yolanda, Martinez, Rafael Benigno, Hernandez, Miguel Teodoro, Gutierrez, Norma C, Puerta, Paloma, Valeri, Antonio, Paiva, Bruno, Blade, Joan, Mateos, Maria-Victoria, San Miguel, Jesus, Lahuerta, Juan Jose, Martinez-Lopez, Joaquin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic Combined Chemotherapy Protocols - therapeutic use Autografts Biochemistry Biology and Life Sciences Care and treatment Chains Clinical trials Clinical Trials, Phase III as Topic Correlation analysis Development and progression Diagnosis Electrophoresis Hematology Humans Immunoglobulin A Immunoglobulin G Immunoglobulin Heavy Chains - blood Immunoglobulin Light Chains - blood Immunoglobulins Induction Chemotherapy Kaplan-Meier Estimate Leukemia Light Light chains Medical prognosis Medical research Medicine and Health Sciences Multiple myeloma Multiple Myeloma - blood Multiple Myeloma - therapy Patients Prognosis Proteins Ratios Research and analysis methods Retrospective Studies Stem Cell Transplantation - methods Studies Survival Transplantation Transplantation, Autologous
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