Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells

Vaccinia-related kinase 1 (VRK1) is a pro-proliferative nuclear kinase. Mice engrafted with VRK1-depleted MDA-MB-231 breast cancer cells have been shown to develop fewer distal metastases than controls, suggesting VRK1 might play a role in cell migration, invasion, and/or colonization. In work descr...

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Veröffentlicht in:	PloS one 2018-09, Vol.13 (9), p.e0203397
Hauptverfasser:	Mon, Aye M, MacKinnon, Jr, A Craig, Traktman, Paula
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Biochemistry Biology and Life Sciences Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - pathology Cadherins - biosynthesis Cadherins - genetics Cancer Cell adhesion & migration Cell culture Cell cycle Cell division Cell growth Cell Line, Tumor Cell migration Cell Movement Cell proliferation Cell spreading Claudin-1 - biosynthesis Claudin-1 - genetics Colonization Cytoskeleton Development and progression E-cadherin Epithelial cells Epithelial-Mesenchymal Transition Female Gene expression Genetic aspects Humans Intracellular Signaling Peptides and Proteins - biosynthesis Intracellular Signaling Peptides and Proteins - genetics Invasiveness Kinases Laboratories Lymph nodes Lymphatic Metastasis Mammary gland Mammary Glands, Human - enzymology Mammary Glands, Human - pathology Medicine and Health Sciences Mesenchyme Metastases Metastasis Molecular biology Neoplasm Invasiveness Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Phosphorylation Physiological aspects Prostate Protein kinases Protein Serine-Threonine Kinases - biosynthesis Protein Serine-Threonine Kinases - genetics Proteins Repressors Research and Analysis Methods Snail protein Transcription factors Tumors Vaccinia Vimentin
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