Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice

Previous studies have shown that modified apelin analogues exhibited enzyme resistance in plasma and improved circulating half-life compared to apelin-13. This study investigated the antidiabetic effects of chronic administration of stable long acting fatty acid modified apelin analogues, namely, (L...

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Veröffentlicht in:	PloS one 2018-08, Vol.13 (8), p.e0202350-e0202350
Hauptverfasser:	O'Harte, Finbarr P M, Parthsarathy, Vadivel, Hogg, Christopher, Flatt, Peter R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Adipose tissue Analysis Animals Anti-Obesity Agents - pharmacology Antidiabetics Biology and Life Sciences Body weight Bone mineral content Carbon dioxide Carbon dioxide exchange Cardiovascular diseases Care and treatment Cholesterol Chronic illnesses Complications and side effects Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diet Diet, High-Fat - adverse effects Energy expenditure Fatty acids Feeding Food intake Glucose High density lipoprotein High fat diet Hyperglycemia Hypertension Hypoglycemic Agents - pharmacology Insulin Insulin resistance Inventors Life expectancy Lipids Lipids - blood Low density lipoprotein Male Medicine and Health Sciences Metabolism Mice Obesity Obesity - blood Obesity - drug therapy Pharmacy Physical Sciences Plasma Risk factors Rodents Sensitivity enhancement Time Factors Triglycerides Type 2 diabetes Weight control
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