Cholesterol-lowering effect of Lactobacillus rhamnosus BFE5264 and its influence on the gut microbiome and propionate level in a murine model
Thanks to recent scientific progress a relationship between the intestinal microbiota and metabolic diseases could be established. A deeper understanding of underlying mechanisms has opened ways towards new approaches for alleviating conditions associated with metabolic diseases. Dysbiosis appears t...
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| creator | Park, Soyoung Kang, Jihee Choi, Sanghaeng Park, Haryung Hwang, Eunchong Kang, Youn-Goo Kim, Ah-Ram Holzapfel, Wilhelm Ji, Yosep |
| description | Thanks to recent scientific progress a relationship between the intestinal microbiota and metabolic diseases could be established. A deeper understanding of underlying mechanisms has opened ways towards new approaches for alleviating conditions associated with metabolic diseases. Dysbiosis appears to be a major underlying factor associated with metabolic syndrome and related adverse health conditions. A major focus has therefore shifted to controlling of the gut microbiota through administration of functional lactic acid bacteria (LAB). The scope for health promotion and/or support by probiotics such as LAB has thereby been widened beyond the improving of intestinal health, also to include anti-obesity, anti-diabetic and cholesterol-lowering effects. In this study we investigated the cholesterol-lowering and microbiota modulatory potential of a LAB strain, Lactobacillus rhamnosus BFE5264, isolated from Maasai fermented milk. A mouse model receiving a high-cholesterol diet served as model for evaluating its functionality. The administration of L. rhamnosus BFE5264 resulted in a significant reduction of the serum cholesterol level that was accompanied by changes in intestinal microbiota and the production of short chain fatty acid (SCFA) in comparison to the control group. This strain also beneficially influenced the regulation of cholesterol metabolism in the liver in a pattern similar to that resulting from statin treatment, a drug inhibiting cholesterol biosynthesis in the liver. |
| doi_str_mv | 10.1371/journal.pone.0203150 |
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A deeper understanding of underlying mechanisms has opened ways towards new approaches for alleviating conditions associated with metabolic diseases. Dysbiosis appears to be a major underlying factor associated with metabolic syndrome and related adverse health conditions. A major focus has therefore shifted to controlling of the gut microbiota through administration of functional lactic acid bacteria (LAB). The scope for health promotion and/or support by probiotics such as LAB has thereby been widened beyond the improving of intestinal health, also to include anti-obesity, anti-diabetic and cholesterol-lowering effects. In this study we investigated the cholesterol-lowering and microbiota modulatory potential of a LAB strain, Lactobacillus rhamnosus BFE5264, isolated from Maasai fermented milk. A mouse model receiving a high-cholesterol diet served as model for evaluating its functionality. The administration of L. rhamnosus BFE5264 resulted in a significant reduction of the serum cholesterol level that was accompanied by changes in intestinal microbiota and the production of short chain fatty acid (SCFA) in comparison to the control group. This strain also beneficially influenced the regulation of cholesterol metabolism in the liver in a pattern similar to that resulting from statin treatment, a drug inhibiting cholesterol biosynthesis in the liver.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0203150</identifier><identifier>PMID: 30153290</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animal models ; Animals ; Bacteria ; Bile ; Biology and Life Sciences ; Biosynthesis ; Blood cholesterol ; Cholesterol ; Cholesterol - administration & dosage ; Cholesterol - metabolism ; Diabetes mellitus ; Diet, High-Fat - adverse effects ; Digestive system ; Digestive tract ; Disease Models, Animal ; Dysbacteriosis ; Energy ; Fatty acids ; Fatty Acids, Volatile - analysis ; Fatty Acids, Volatile - metabolism ; Feces - chemistry ; Feces - microbiology ; Fermented milk products ; Food ; Gastrointestinal Microbiome ; Gastrointestinal tract ; Gene expression ; Health aspects ; Health promotion ; High cholesterol diet ; Intestinal microflora ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - microbiology ; Intestine ; Laboratory animals ; Lactic acid ; Lactic acid bacteria ; Lactobacillus ; Lactobacillus rhamnosus ; Life sciences ; Lipid metabolism ; Liver ; Liver - metabolism ; Male ; Medical research ; Medicine and Health Sciences ; Metabolic disorders ; Metabolic regulation ; Metabolic syndrome ; Metabolism ; Mice, Inbred C57BL ; Microbiomes ; Microbiota ; Microbiota (Symbiotic organisms) ; Nutrition research ; Physiological aspects ; Probiotics ; Probiotics - administration & dosage ; Propionates - metabolism ; Propionic acid ; RNA, Messenger ; Rodents</subject><ispartof>PloS one, 2018-08, Vol.13 (8), p.e0203150-e0203150</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Park et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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A deeper understanding of underlying mechanisms has opened ways towards new approaches for alleviating conditions associated with metabolic diseases. Dysbiosis appears to be a major underlying factor associated with metabolic syndrome and related adverse health conditions. A major focus has therefore shifted to controlling of the gut microbiota through administration of functional lactic acid bacteria (LAB). The scope for health promotion and/or support by probiotics such as LAB has thereby been widened beyond the improving of intestinal health, also to include anti-obesity, anti-diabetic and cholesterol-lowering effects. In this study we investigated the cholesterol-lowering and microbiota modulatory potential of a LAB strain, Lactobacillus rhamnosus BFE5264, isolated from Maasai fermented milk. A mouse model receiving a high-cholesterol diet served as model for evaluating its functionality. The administration of L. rhamnosus BFE5264 resulted in a significant reduction of the serum cholesterol level that was accompanied by changes in intestinal microbiota and the production of short chain fatty acid (SCFA) in comparison to the control group. This strain also beneficially influenced the regulation of cholesterol metabolism in the liver in a pattern similar to that resulting from statin treatment, a drug inhibiting cholesterol biosynthesis in the liver.</description><subject>Analysis</subject><subject>Animal models</subject><subject>Animals</subject><subject>Bacteria</subject><subject>Bile</subject><subject>Biology and Life Sciences</subject><subject>Biosynthesis</subject><subject>Blood cholesterol</subject><subject>Cholesterol</subject><subject>Cholesterol - administration & dosage</subject><subject>Cholesterol - metabolism</subject><subject>Diabetes mellitus</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Digestive system</subject><subject>Digestive tract</subject><subject>Disease Models, Animal</subject><subject>Dysbacteriosis</subject><subject>Energy</subject><subject>Fatty acids</subject><subject>Fatty Acids, Volatile - analysis</subject><subject>Fatty Acids, Volatile - metabolism</subject><subject>Feces - 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A deeper understanding of underlying mechanisms has opened ways towards new approaches for alleviating conditions associated with metabolic diseases. Dysbiosis appears to be a major underlying factor associated with metabolic syndrome and related adverse health conditions. A major focus has therefore shifted to controlling of the gut microbiota through administration of functional lactic acid bacteria (LAB). The scope for health promotion and/or support by probiotics such as LAB has thereby been widened beyond the improving of intestinal health, also to include anti-obesity, anti-diabetic and cholesterol-lowering effects. In this study we investigated the cholesterol-lowering and microbiota modulatory potential of a LAB strain, Lactobacillus rhamnosus BFE5264, isolated from Maasai fermented milk. A mouse model receiving a high-cholesterol diet served as model for evaluating its functionality. The administration of L. rhamnosus BFE5264 resulted in a significant reduction of the serum cholesterol level that was accompanied by changes in intestinal microbiota and the production of short chain fatty acid (SCFA) in comparison to the control group. This strain also beneficially influenced the regulation of cholesterol metabolism in the liver in a pattern similar to that resulting from statin treatment, a drug inhibiting cholesterol biosynthesis in the liver.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30153290</pmid><doi>10.1371/journal.pone.0203150</doi><tpages>e0203150</tpages><orcidid>https://orcid.org/0000-0001-5349-7901</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2095467966 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Animal models Animals Bacteria Bile Biology and Life Sciences Biosynthesis Blood cholesterol Cholesterol Cholesterol - administration & dosage Cholesterol - metabolism Diabetes mellitus Diet, High-Fat - adverse effects Digestive system Digestive tract Disease Models, Animal Dysbacteriosis Energy Fatty acids Fatty Acids, Volatile - analysis Fatty Acids, Volatile - metabolism Feces - chemistry Feces - microbiology Fermented milk products Food Gastrointestinal Microbiome Gastrointestinal tract Gene expression Health aspects Health promotion High cholesterol diet Intestinal microflora Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestine Laboratory animals Lactic acid Lactic acid bacteria Lactobacillus Lactobacillus rhamnosus Life sciences Lipid metabolism Liver Liver - metabolism Male Medical research Medicine and Health Sciences Metabolic disorders Metabolic regulation Metabolic syndrome Metabolism Mice, Inbred C57BL Microbiomes Microbiota Microbiota (Symbiotic organisms) Nutrition research Physiological aspects Probiotics Probiotics - administration & dosage Propionates - metabolism Propionic acid RNA, Messenger Rodents |
| title | Cholesterol-lowering effect of Lactobacillus rhamnosus BFE5264 and its influence on the gut microbiome and propionate level in a murine model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T07%3A12%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cholesterol-lowering%20effect%20of%20Lactobacillus%20rhamnosus%20BFE5264%20and%20its%20influence%20on%20the%20gut%20microbiome%20and%20propionate%20level%20in%20a%20murine%20model&rft.jtitle=PloS%20one&rft.au=Park,%20Soyoung&rft.date=2018-08-28&rft.volume=13&rft.issue=8&rft.spage=e0203150&rft.epage=e0203150&rft.pages=e0203150-e0203150&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0203150&rft_dat=%3Cgale_plos_%3EA557799659%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2095467966&rft_id=info:pmid/30153290&rft_galeid=A557799659&rft_doaj_id=oai_doaj_org_article_d34cfee6462441ad8c788e62c11abeef&rfr_iscdi=true |