Chemoproteomic identification of molecular targets of antifungal prototypes, thiosemicarbazide and a camphene derivative of thiosemicarbazide, in Paracoccidioides brasiliensis

Paracoccidioidomycosis (PCM) is a neglected human systemic disease caused by species of the genus Paracoccidioides. The disease attacks the host's lungs and may disseminate to many other organs. Treatment involves amphotericin B, sulfadiazine, trimethoprim-sulfamethoxazole, itraconazole, ketoco...

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Veröffentlicht in:	PloS one 2018-08, Vol.13 (8), p.e0201948
Hauptverfasser:	Borba, Joyce Villa Verde Bastos, Tauhata, Sinji Borges Ferreira, Oliveira, Cecília Maria Alves de, Ferreira Marques, Monique, Bailão, Alexandre Melo, Soares, Célia Maria de Almeida, Pereira, Maristela
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - metabolism Amphotericin B Animals Antifungal agents Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Apoptosis BALB 3T3 Cells Biology and Life Sciences Camphene Carbohydrates Cell cycle Cell division Cell Survival - drug effects Chemical properties Dimorphism Drug Discovery Drug therapy Enzyme Activation - drug effects Fluconazole Formamidase Fungal infections Fungal Proteins - antagonists & inhibitors Fungal Proteins - metabolism Fungi Fungicides Glycolysis Humans Identification and classification Itraconazole Ketoconazole Lungs Mice Microbial Sensitivity Tests Mode of action Morphogenesis Organs Paracoccidioides - drug effects Paracoccidioides - metabolism Paracoccidioidomycosis Peptidases Phylogenetics Proteasomes Protein Binding Proteins Proteomics Proteomics - methods Prototypes Semicarbazides - chemistry Semicarbazides - isolation & purification Semicarbazides - pharmacology South American blastomycosis Sulfadiazine Sulfamethoxazole Target recognition Thiosemicarbazides Trimethoprim Trimethoprim-sulfamethoxazole Yeast Yeasts
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