Modelling mesenchymal stromal cell growth in a packed bed bioreactor with a gas permeable wall

A mathematical model was developed for mesenchymal stromal cell (MSC) growth in a packed bed bioreactor that improves oxygen availability by allowing oxygen diffusion through a gas-permeable wall. The governing equations for oxygen, glucose and lactate, the inhibitory waste product, were developed a...

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Veröffentlicht in:	PloS one 2018-08, Vol.13 (8), p.e0202079-e0202079
Hauptverfasser:	Osiecki, Michael J, McElwain, Sean D L, Lott, William B
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Batch Cell Culture Techniques Bioengineering Biology and Life Sciences Bioreactors Biotechnology Cell culture Cell growth Cell migration Cell Proliferation Confluence Conservation Design Design modifications Finite element method Flow rates Flow velocity Gas permeable walls Growth Growth rate Health aspects Hypoxia Kinetics Lactic acid Lag phase Mathematical models Mathematics Mechanical engineering Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mesenchyme Metabolism Metabolites Models, Biological Nutrient concentrations Nutrients Oxygen Oxygen Consumption Packed beds Packing density Permeability Physical Sciences Physiology Pore size Reaction kinetics Reynolds number Stem cells Stress, Physiological Testing Tissue engineering
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