Tanshinone IIA attenuates nerve structural and functional damage induced by nerve crush injury in rats
After peripheral nerve crush injury, the fibers of distal nerve segments gradually disintegrate, and axons regrow from the proximal nerve segment, eventually reaching the target organ. However, the axon regeneration is generally not sufficient for the recovery of neurological function, so drug thera...
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| description | After peripheral nerve crush injury, the fibers of distal nerve segments gradually disintegrate, and axons regrow from the proximal nerve segment, eventually reaching the target organ. However, the axon regeneration is generally not sufficient for the recovery of neurological function, so drug therapy is necessary. In the current study, we explored the effect of Tanshinone IIA in nerve regeneration in a sciatic nerve crush injury model using Sprague Dawley rats. The rats were administered 45 mg/kg of Tanshinone IIA once daily. Motor behavior and tibialis anterior muscle mass were assessed, and histological analysis of the sciatic nerve and lumbar spinal cord were conducted. The results showed that the administration of Tanshinone IIA improved nerve growth and motor function, and resulted in a marked decrease of neuronal death. The findings of this exploratory study suggest that Tanshinone IIA alleviates injury and boosts regeneration after nerve crush injury in a rat model of sciatic nerve injury. |
| doi_str_mv | 10.1371/journal.pone.0202532 |
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However, the axon regeneration is generally not sufficient for the recovery of neurological function, so drug therapy is necessary. In the current study, we explored the effect of Tanshinone IIA in nerve regeneration in a sciatic nerve crush injury model using Sprague Dawley rats. The rats were administered 45 mg/kg of Tanshinone IIA once daily. Motor behavior and tibialis anterior muscle mass were assessed, and histological analysis of the sciatic nerve and lumbar spinal cord were conducted. The results showed that the administration of Tanshinone IIA improved nerve growth and motor function, and resulted in a marked decrease of neuronal death. The findings of this exploratory study suggest that Tanshinone IIA alleviates injury and boosts regeneration after nerve crush injury in a rat model of sciatic nerve injury.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0202532</identifier><identifier>PMID: 30138344</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animals ; Axon guidance ; Axons ; Biology and Life Sciences ; Cell Death - drug effects ; Crush Injuries - drug therapy ; Crush Injuries - physiopathology ; Crushing ; Diterpenes, Abietane - administration & dosage ; Drug therapy ; Embryology ; Growth factors ; Health aspects ; Herbal medicine ; Humans ; Injuries ; Ischemia ; Laboratory animals ; Medical research ; Medicine and Health Sciences ; Motor task performance ; Muscles ; Nerve Crush ; Nerve Regeneration - drug effects ; Neurons - drug effects ; Neurons - pathology ; Orthopedics ; Peripheral nerves ; Peripheral nervous system diseases ; Polypeptides ; Quality of life ; Rats ; Regeneration ; Researchers ; Rodents ; Schwann cells ; Sciatic nerve ; Sciatic Nerve - drug effects ; Sciatic Nerve - growth & development ; Sciatic Nerve - injuries ; Sciatic Nerve - physiopathology ; Skeletal muscle ; Spinal cord ; Structure-function relationships ; Studies ; Tibialis anterior muscle ; Trauma</subject><ispartof>PloS one, 2018-08, Vol.13 (8), p.e0202532-e0202532</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Wang et al 2018 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-5771483c78266b7c5ab53b02adb8db2a6880e4c7cdf2d912f63f3e79d04ecc453</citedby><cites>FETCH-LOGICAL-c692t-5771483c78266b7c5ab53b02adb8db2a6880e4c7cdf2d912f63f3e79d04ecc453</cites><orcidid>0000-0002-8379-1607</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107165/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107165/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23868,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30138344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Phillips, William D</contributor><creatorcontrib>Wang, Zhiyong</creatorcontrib><creatorcontrib>Yang, Xiaomei</creatorcontrib><creatorcontrib>Zhang, Weiguang</creatorcontrib><creatorcontrib>Zhang, Peixun</creatorcontrib><creatorcontrib>Jiang, Baoguo</creatorcontrib><title>Tanshinone IIA attenuates nerve structural and functional damage induced by nerve crush injury in rats</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>After peripheral nerve crush injury, the fibers of distal nerve segments gradually disintegrate, and axons regrow from the proximal nerve segment, eventually reaching the target organ. However, the axon regeneration is generally not sufficient for the recovery of neurological function, so drug therapy is necessary. In the current study, we explored the effect of Tanshinone IIA in nerve regeneration in a sciatic nerve crush injury model using Sprague Dawley rats. The rats were administered 45 mg/kg of Tanshinone IIA once daily. Motor behavior and tibialis anterior muscle mass were assessed, and histological analysis of the sciatic nerve and lumbar spinal cord were conducted. The results showed that the administration of Tanshinone IIA improved nerve growth and motor function, and resulted in a marked decrease of neuronal death. The findings of this exploratory study suggest that Tanshinone IIA alleviates injury and boosts regeneration after nerve crush injury in a rat model of sciatic nerve injury.</description><subject>Analysis</subject><subject>Animals</subject><subject>Axon guidance</subject><subject>Axons</subject><subject>Biology and Life Sciences</subject><subject>Cell Death - drug effects</subject><subject>Crush Injuries - drug therapy</subject><subject>Crush Injuries - physiopathology</subject><subject>Crushing</subject><subject>Diterpenes, Abietane - administration & dosage</subject><subject>Drug therapy</subject><subject>Embryology</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Herbal medicine</subject><subject>Humans</subject><subject>Injuries</subject><subject>Ischemia</subject><subject>Laboratory animals</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Motor task performance</subject><subject>Muscles</subject><subject>Nerve Crush</subject><subject>Nerve Regeneration - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Zhiyong</au><au>Yang, Xiaomei</au><au>Zhang, Weiguang</au><au>Zhang, Peixun</au><au>Jiang, Baoguo</au><au>Phillips, William D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tanshinone IIA attenuates nerve structural and functional damage induced by nerve crush injury in rats</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-08-23</date><risdate>2018</risdate><volume>13</volume><issue>8</issue><spage>e0202532</spage><epage>e0202532</epage><pages>e0202532-e0202532</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>After peripheral nerve crush injury, the fibers of distal nerve segments gradually disintegrate, and axons regrow from the proximal nerve segment, eventually reaching the target organ. However, the axon regeneration is generally not sufficient for the recovery of neurological function, so drug therapy is necessary. In the current study, we explored the effect of Tanshinone IIA in nerve regeneration in a sciatic nerve crush injury model using Sprague Dawley rats. The rats were administered 45 mg/kg of Tanshinone IIA once daily. Motor behavior and tibialis anterior muscle mass were assessed, and histological analysis of the sciatic nerve and lumbar spinal cord were conducted. The results showed that the administration of Tanshinone IIA improved nerve growth and motor function, and resulted in a marked decrease of neuronal death. The findings of this exploratory study suggest that Tanshinone IIA alleviates injury and boosts regeneration after nerve crush injury in a rat model of sciatic nerve injury.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30138344</pmid><doi>10.1371/journal.pone.0202532</doi><tpages>e0202532</tpages><orcidid>https://orcid.org/0000-0002-8379-1607</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Animals Axon guidance Axons Biology and Life Sciences Cell Death - drug effects Crush Injuries - drug therapy Crush Injuries - physiopathology Crushing Diterpenes, Abietane - administration & dosage Drug therapy Embryology Growth factors Health aspects Herbal medicine Humans Injuries Ischemia Laboratory animals Medical research Medicine and Health Sciences Motor task performance Muscles Nerve Crush Nerve Regeneration - drug effects Neurons - drug effects Neurons - pathology Orthopedics Peripheral nerves Peripheral nervous system diseases Polypeptides Quality of life Rats Regeneration Researchers Rodents Schwann cells Sciatic nerve Sciatic Nerve - drug effects Sciatic Nerve - growth & development Sciatic Nerve - injuries Sciatic Nerve - physiopathology Skeletal muscle Spinal cord Structure-function relationships Studies Tibialis anterior muscle Trauma |
| title | Tanshinone IIA attenuates nerve structural and functional damage induced by nerve crush injury in rats |
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