Marker of vitamin D status in healthy children: Free or total 25-hydroxyvitamin D?
To assess if serum free 25-hydroxyvitamin D (25OHD) is a better indicator of vitamin D status than total 25OHD in healthy children. Cross-sectional prospective clinical study was designed. We measured serum free 25OHD concentrations and its correlation with calculated free 25OHD, total 25OHD, intact...
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| creator | Mantecón, Laura Alonso, Mª Agustina Moya, Vanessa Andrés, Ana Gloria Avello, Noelia Martínez-Morillo, Eduardo Santos, Fernando |
| description | To assess if serum free 25-hydroxyvitamin D (25OHD) is a better indicator of vitamin D status than total 25OHD in healthy children.
Cross-sectional prospective clinical study was designed. We measured serum free 25OHD concentrations and its correlation with calculated free 25OHD, total 25OHD, intact parathyroid hormone (PTH), and vitamin D binding protein (DBP) in children. The influence of age, sex, ethnicity, body mass index (BMI), season of the year, diet intake, vitamin supplements, time spent outdoors and albumin concentrations on free 25OHD was also analyzed. 241 children aged from 0 days to 14 years, and living in the northern Spain (latitude 43° N), were included.
Mean (SD) free 25OHD concentrations were 2.48 (1.39), 5.46 (3.12), 4.12 (1,72), 3.82 (1.43) pg/ml in children aged 0 days, 1 month-2 years, 2-6 years and >6 years, respectively. Correlation between directly measured and calculated free 25OHD was high and significant (r = 0.66) as well as the correlation between serum free and total 25OHD concentrations (r = 0.61). No significant correlation was found between PTH and free 25OHD (r = -0.08). The total 25OHD and PTH concentrations' correlation was inverse (r = -0.25) and significant. Neither free nor total 25OHD concentrations correlated with DBP concentrations. Among the analyzed variables, free 25OHD values were higher in spring/summer than in autumn/winter in children older than 6 years.
: These findings do not support that free 25OHD is a better marker of vitamin D deficiency than total 25OHD in healthy pediatric population. |
| doi_str_mv | 10.1371/journal.pone.0202237 |
| format | Article |
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Cross-sectional prospective clinical study was designed. We measured serum free 25OHD concentrations and its correlation with calculated free 25OHD, total 25OHD, intact parathyroid hormone (PTH), and vitamin D binding protein (DBP) in children. The influence of age, sex, ethnicity, body mass index (BMI), season of the year, diet intake, vitamin supplements, time spent outdoors and albumin concentrations on free 25OHD was also analyzed. 241 children aged from 0 days to 14 years, and living in the northern Spain (latitude 43° N), were included.
Mean (SD) free 25OHD concentrations were 2.48 (1.39), 5.46 (3.12), 4.12 (1,72), 3.82 (1.43) pg/ml in children aged 0 days, 1 month-2 years, 2-6 years and >6 years, respectively. Correlation between directly measured and calculated free 25OHD was high and significant (r = 0.66) as well as the correlation between serum free and total 25OHD concentrations (r = 0.61). No significant correlation was found between PTH and free 25OHD (r = -0.08). The total 25OHD and PTH concentrations' correlation was inverse (r = -0.25) and significant. Neither free nor total 25OHD concentrations correlated with DBP concentrations. Among the analyzed variables, free 25OHD values were higher in spring/summer than in autumn/winter in children older than 6 years.
: These findings do not support that free 25OHD is a better marker of vitamin D deficiency than total 25OHD in healthy pediatric population.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0202237</identifier><identifier>PMID: 30138329</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>25-Hydroxyvitamin D ; Adult children ; Alonso, Fernando ; Analysis ; Binding proteins ; Bioavailability ; Biochemistry ; Biological markers ; Biology and Life Sciences ; Body mass ; Body mass index ; Body size ; Bone density ; Children ; Correlation ; Correlation analysis ; Dietary supplements ; Health aspects ; Health services ; Hormones ; Hypotheses ; Mathematical analysis ; Medicine and Health Sciences ; Metabolism ; Minority & ethnic groups ; Newborn babies ; Nutrient deficiency ; Parathyroid ; Parathyroid hormone ; Pediatrics ; People and Places ; Physical sciences ; Proteins ; Studies ; Vitamin D ; Vitamin deficiency</subject><ispartof>PloS one, 2018-08, Vol.13 (8), p.e0202237-e0202237</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Mantecón et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Mantecón et al 2018 Mantecón et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-946ae23a42d1a00ffad09905d1b775b60a14d62f1ed4ccf0f96ae33bc44916863</citedby><cites>FETCH-LOGICAL-c692t-946ae23a42d1a00ffad09905d1b775b60a14d62f1ed4ccf0f96ae33bc44916863</cites><orcidid>0000-0001-6770-8263 ; 0000-0002-1206-3346</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107142/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107142/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30138329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Reddy, Sakamuri V.</contributor><creatorcontrib>Mantecón, Laura</creatorcontrib><creatorcontrib>Alonso, Mª Agustina</creatorcontrib><creatorcontrib>Moya, Vanessa</creatorcontrib><creatorcontrib>Andrés, Ana Gloria</creatorcontrib><creatorcontrib>Avello, Noelia</creatorcontrib><creatorcontrib>Martínez-Morillo, Eduardo</creatorcontrib><creatorcontrib>Santos, Fernando</creatorcontrib><title>Marker of vitamin D status in healthy children: Free or total 25-hydroxyvitamin D?</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To assess if serum free 25-hydroxyvitamin D (25OHD) is a better indicator of vitamin D status than total 25OHD in healthy children.
Cross-sectional prospective clinical study was designed. We measured serum free 25OHD concentrations and its correlation with calculated free 25OHD, total 25OHD, intact parathyroid hormone (PTH), and vitamin D binding protein (DBP) in children. The influence of age, sex, ethnicity, body mass index (BMI), season of the year, diet intake, vitamin supplements, time spent outdoors and albumin concentrations on free 25OHD was also analyzed. 241 children aged from 0 days to 14 years, and living in the northern Spain (latitude 43° N), were included.
Mean (SD) free 25OHD concentrations were 2.48 (1.39), 5.46 (3.12), 4.12 (1,72), 3.82 (1.43) pg/ml in children aged 0 days, 1 month-2 years, 2-6 years and >6 years, respectively. Correlation between directly measured and calculated free 25OHD was high and significant (r = 0.66) as well as the correlation between serum free and total 25OHD concentrations (r = 0.61). No significant correlation was found between PTH and free 25OHD (r = -0.08). The total 25OHD and PTH concentrations' correlation was inverse (r = -0.25) and significant. Neither free nor total 25OHD concentrations correlated with DBP concentrations. Among the analyzed variables, free 25OHD values were higher in spring/summer than in autumn/winter in children older than 6 years.
: These findings do not support that free 25OHD is a better marker of vitamin D deficiency than total 25OHD in healthy pediatric population.</description><subject>25-Hydroxyvitamin D</subject><subject>Adult children</subject><subject>Alonso, Fernando</subject><subject>Analysis</subject><subject>Binding proteins</subject><subject>Bioavailability</subject><subject>Biochemistry</subject><subject>Biological markers</subject><subject>Biology and Life Sciences</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Bone density</subject><subject>Children</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Dietary supplements</subject><subject>Health aspects</subject><subject>Health services</subject><subject>Hormones</subject><subject>Hypotheses</subject><subject>Mathematical analysis</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Minority & ethnic groups</subject><subject>Newborn babies</subject><subject>Nutrient deficiency</subject><subject>Parathyroid</subject><subject>Parathyroid hormone</subject><subject>Pediatrics</subject><subject>People and Places</subject><subject>Physical sciences</subject><subject>Proteins</subject><subject>Studies</subject><subject>Vitamin D</subject><subject>Vitamin 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of vitamin D status in healthy children: Free or total 25-hydroxyvitamin D?</title><author>Mantecón, Laura ; Alonso, Mª Agustina ; Moya, Vanessa ; Andrés, Ana Gloria ; Avello, Noelia ; Martínez-Morillo, Eduardo ; Santos, Fernando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-946ae23a42d1a00ffad09905d1b775b60a14d62f1ed4ccf0f96ae33bc44916863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Adult children</topic><topic>Alonso, Fernando</topic><topic>Analysis</topic><topic>Binding proteins</topic><topic>Bioavailability</topic><topic>Biochemistry</topic><topic>Biological markers</topic><topic>Biology and Life Sciences</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Bone density</topic><topic>Children</topic><topic>Correlation</topic><topic>Correlation analysis</topic><topic>Dietary supplements</topic><topic>Health aspects</topic><topic>Health services</topic><topic>Hormones</topic><topic>Hypotheses</topic><topic>Mathematical analysis</topic><topic>Medicine and Health Sciences</topic><topic>Metabolism</topic><topic>Minority & ethnic groups</topic><topic>Newborn babies</topic><topic>Nutrient deficiency</topic><topic>Parathyroid</topic><topic>Parathyroid hormone</topic><topic>Pediatrics</topic><topic>People and Places</topic><topic>Physical sciences</topic><topic>Proteins</topic><topic>Studies</topic><topic>Vitamin D</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mantecón, Laura</creatorcontrib><creatorcontrib>Alonso, Mª Agustina</creatorcontrib><creatorcontrib>Moya, Vanessa</creatorcontrib><creatorcontrib>Andrés, Ana Gloria</creatorcontrib><creatorcontrib>Avello, Noelia</creatorcontrib><creatorcontrib>Martínez-Morillo, Eduardo</creatorcontrib><creatorcontrib>Santos, 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one</jtitle><addtitle>PLoS One</addtitle><date>2018-08-23</date><risdate>2018</risdate><volume>13</volume><issue>8</issue><spage>e0202237</spage><epage>e0202237</epage><pages>e0202237-e0202237</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To assess if serum free 25-hydroxyvitamin D (25OHD) is a better indicator of vitamin D status than total 25OHD in healthy children.
Cross-sectional prospective clinical study was designed. We measured serum free 25OHD concentrations and its correlation with calculated free 25OHD, total 25OHD, intact parathyroid hormone (PTH), and vitamin D binding protein (DBP) in children. The influence of age, sex, ethnicity, body mass index (BMI), season of the year, diet intake, vitamin supplements, time spent outdoors and albumin concentrations on free 25OHD was also analyzed. 241 children aged from 0 days to 14 years, and living in the northern Spain (latitude 43° N), were included.
Mean (SD) free 25OHD concentrations were 2.48 (1.39), 5.46 (3.12), 4.12 (1,72), 3.82 (1.43) pg/ml in children aged 0 days, 1 month-2 years, 2-6 years and >6 years, respectively. Correlation between directly measured and calculated free 25OHD was high and significant (r = 0.66) as well as the correlation between serum free and total 25OHD concentrations (r = 0.61). No significant correlation was found between PTH and free 25OHD (r = -0.08). The total 25OHD and PTH concentrations' correlation was inverse (r = -0.25) and significant. Neither free nor total 25OHD concentrations correlated with DBP concentrations. Among the analyzed variables, free 25OHD values were higher in spring/summer than in autumn/winter in children older than 6 years.
: These findings do not support that free 25OHD is a better marker of vitamin D deficiency than total 25OHD in healthy pediatric population.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30138329</pmid><doi>10.1371/journal.pone.0202237</doi><tpages>e0202237</tpages><orcidid>https://orcid.org/0000-0001-6770-8263</orcidid><orcidid>https://orcid.org/0000-0002-1206-3346</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2018-08, Vol.13 (8), p.e0202237-e0202237 |
| issn | 1932-6203 1932-6203 |
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| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 25-Hydroxyvitamin D Adult children Alonso, Fernando Analysis Binding proteins Bioavailability Biochemistry Biological markers Biology and Life Sciences Body mass Body mass index Body size Bone density Children Correlation Correlation analysis Dietary supplements Health aspects Health services Hormones Hypotheses Mathematical analysis Medicine and Health Sciences Metabolism Minority & ethnic groups Newborn babies Nutrient deficiency Parathyroid Parathyroid hormone Pediatrics People and Places Physical sciences Proteins Studies Vitamin D Vitamin deficiency |
| title | Marker of vitamin D status in healthy children: Free or total 25-hydroxyvitamin D? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T14%3A25%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Marker%20of%20vitamin%20D%20status%20in%20healthy%20children:%20Free%20or%20total%2025-hydroxyvitamin%20D?&rft.jtitle=PloS%20one&rft.au=Mantec%C3%B3n,%20Laura&rft.date=2018-08-23&rft.volume=13&rft.issue=8&rft.spage=e0202237&rft.epage=e0202237&rft.pages=e0202237-e0202237&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0202237&rft_dat=%3Cgale_plos_%3EA551445782%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2092586414&rft_id=info:pmid/30138329&rft_galeid=A551445782&rft_doaj_id=oai_doaj_org_article_1a367419e5b44b9f983c754b62afa35e&rfr_iscdi=true |