An in-vivo pilot study into the effects of FDG-mNP in cancer in mice
Previously, fluorodeoxy glucose conjugated magnetite nanoparticles (FDG-mNPs) injected into cancer cells in conjunction with the application of magnetic hyperthermia have shown promise in new FDG-mNPs applications. The aim of this study was to determine potential toxic or unwanted effects involving...
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| Veröffentlicht in: | PloS one 2018-08, Vol.13 (8), p.e0202482 |
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| creator | Aras, Omer Pearce, Gillian Watkins, Adam J Nurili, Fuad Medine, Emin Ilker Guldu, Ozge Kozgus Tekin, Volkan Wong, Julian Ma, Xianghong Ting, Richard Unak, Perihan Akin, Oguz |
| description | Previously, fluorodeoxy glucose conjugated magnetite nanoparticles (FDG-mNPs) injected into cancer cells in conjunction with the application of magnetic hyperthermia have shown promise in new FDG-mNPs applications. The aim of this study was to determine potential toxic or unwanted effects involving both tumour cells and normal tissue in other organs when FDG-mNPs are administered intravenously or intratumourally in mice.
FDG-mNPs were synthesized. A group of six prostate-tumour bearing mice were injected with 23.42 mg/ml FDG-mNPs (intravenous injection, n = 3; intratumoural injection into the prostate tumour, n = 3). Mice were euthanized and histological sampling of tissue was conducted for the prostate tumour, as well as for lungs, lymph nodes, liver, kidneys, spleen, and brain, at 1 hour (n = 2) and 7 days (n = 4) post-injection. A second group of two normal (non-cancerous) mice received the same injection intravenously into the tail vein and were euthanised at 3 and 6 months post-injection, respectively, to investigate if FDG-mNPs remained in organs at those time points.
In prostate-tumour bearing mice, FDG-mNPs concentrated in the prostate tumour, while relatively small amounts were found in the organs of other tissues, particularly the spleen and the liver; FDG-mNP concentrations decreased over time in all tissues. In normal mice, no detrimental effects were found in either mouse at 3 or 6 months.
Intravenous or intratumoural FDG-mNPs can be safely administered for effective cancer cell destruction. Further research on the clinical utility of FDG-mNPs will be conducted by applying hyperthermia in conjunction with FDG-mNPs in mice. |
| doi_str_mv | 10.1371/journal.pone.0202482 |
| format | Article |
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FDG-mNPs were synthesized. A group of six prostate-tumour bearing mice were injected with 23.42 mg/ml FDG-mNPs (intravenous injection, n = 3; intratumoural injection into the prostate tumour, n = 3). Mice were euthanized and histological sampling of tissue was conducted for the prostate tumour, as well as for lungs, lymph nodes, liver, kidneys, spleen, and brain, at 1 hour (n = 2) and 7 days (n = 4) post-injection. A second group of two normal (non-cancerous) mice received the same injection intravenously into the tail vein and were euthanised at 3 and 6 months post-injection, respectively, to investigate if FDG-mNPs remained in organs at those time points.
In prostate-tumour bearing mice, FDG-mNPs concentrated in the prostate tumour, while relatively small amounts were found in the organs of other tissues, particularly the spleen and the liver; FDG-mNP concentrations decreased over time in all tissues. In normal mice, no detrimental effects were found in either mouse at 3 or 6 months.
Intravenous or intratumoural FDG-mNPs can be safely administered for effective cancer cell destruction. Further research on the clinical utility of FDG-mNPs will be conducted by applying hyperthermia in conjunction with FDG-mNPs in mice.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0202482</identifier><identifier>PMID: 30125303</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animal tissues ; Animals ; Applied physics ; Biocompatibility ; Biology and Life Sciences ; Brain ; Breast cancer ; Cancer ; Cancer research ; Cancer therapies ; Cardiovascular disease ; Chemotherapy ; Childrens health ; Engineering and Technology ; Fever ; Glucose ; Glucose-6-Phosphate - analogs & derivatives ; Glucose-6-Phosphate - pharmacokinetics ; Glucose-6-Phosphate - pharmacology ; Gynecology ; Hyperthermia ; Hyperthermia, Induced ; Injection ; Intravenous administration ; Kidneys ; Liver ; Lungs ; Lymph nodes ; Magnetite ; Magnetite Nanoparticles - therapeutic use ; Male ; Medical imaging ; Medical research ; Medicine and Health Sciences ; Metabolism ; Mice ; Nanoparticles ; Neoplasms, Experimental - metabolism ; Neoplasms, Experimental - pathology ; Neoplasms, Experimental - therapy ; Neuroblastoma ; NMR ; Nuclear magnetic resonance ; Obstetrics ; Organ Specificity ; Organs ; Pilot Projects ; Prostate ; Prostate cancer ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - therapy ; Radiation therapy ; Research and Analysis Methods ; Skin cancer ; Spleen ; Studies ; Tumors</subject><ispartof>PloS one, 2018-08, Vol.13 (8), p.e0202482</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-87d2e21140a8f8aaa5e65d07e727b31cf9dad54a7f6f3f0d926f3a023e548e0f3</citedby><cites>FETCH-LOGICAL-c585t-87d2e21140a8f8aaa5e65d07e727b31cf9dad54a7f6f3f0d926f3a023e548e0f3</cites><orcidid>0000-0003-1758-0542 ; 0000-0002-0413-9363 ; 0000-0002-0264-3814</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101388/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101388/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30125303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aras, Omer</creatorcontrib><creatorcontrib>Pearce, Gillian</creatorcontrib><creatorcontrib>Watkins, Adam J</creatorcontrib><creatorcontrib>Nurili, Fuad</creatorcontrib><creatorcontrib>Medine, Emin Ilker</creatorcontrib><creatorcontrib>Guldu, Ozge Kozgus</creatorcontrib><creatorcontrib>Tekin, Volkan</creatorcontrib><creatorcontrib>Wong, Julian</creatorcontrib><creatorcontrib>Ma, Xianghong</creatorcontrib><creatorcontrib>Ting, Richard</creatorcontrib><creatorcontrib>Unak, Perihan</creatorcontrib><creatorcontrib>Akin, Oguz</creatorcontrib><title>An in-vivo pilot study into the effects of FDG-mNP in cancer in mice</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Previously, fluorodeoxy glucose conjugated magnetite nanoparticles (FDG-mNPs) injected into cancer cells in conjunction with the application of magnetic hyperthermia have shown promise in new FDG-mNPs applications. The aim of this study was to determine potential toxic or unwanted effects involving both tumour cells and normal tissue in other organs when FDG-mNPs are administered intravenously or intratumourally in mice.
FDG-mNPs were synthesized. A group of six prostate-tumour bearing mice were injected with 23.42 mg/ml FDG-mNPs (intravenous injection, n = 3; intratumoural injection into the prostate tumour, n = 3). Mice were euthanized and histological sampling of tissue was conducted for the prostate tumour, as well as for lungs, lymph nodes, liver, kidneys, spleen, and brain, at 1 hour (n = 2) and 7 days (n = 4) post-injection. A second group of two normal (non-cancerous) mice received the same injection intravenously into the tail vein and were euthanised at 3 and 6 months post-injection, respectively, to investigate if FDG-mNPs remained in organs at those time points.
In prostate-tumour bearing mice, FDG-mNPs concentrated in the prostate tumour, while relatively small amounts were found in the organs of other tissues, particularly the spleen and the liver; FDG-mNP concentrations decreased over time in all tissues. In normal mice, no detrimental effects were found in either mouse at 3 or 6 months.
Intravenous or intratumoural FDG-mNPs can be safely administered for effective cancer cell destruction. Further research on the clinical utility of FDG-mNPs will be conducted by applying hyperthermia in conjunction with FDG-mNPs in mice.</description><subject>Animal tissues</subject><subject>Animals</subject><subject>Applied physics</subject><subject>Biocompatibility</subject><subject>Biology and Life Sciences</subject><subject>Brain</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>Cardiovascular disease</subject><subject>Chemotherapy</subject><subject>Childrens health</subject><subject>Engineering and Technology</subject><subject>Fever</subject><subject>Glucose</subject><subject>Glucose-6-Phosphate - analogs & derivatives</subject><subject>Glucose-6-Phosphate - pharmacokinetics</subject><subject>Glucose-6-Phosphate - pharmacology</subject><subject>Gynecology</subject><subject>Hyperthermia</subject><subject>Hyperthermia, Induced</subject><subject>Injection</subject><subject>Intravenous administration</subject><subject>Kidneys</subject><subject>Liver</subject><subject>Lungs</subject><subject>Lymph nodes</subject><subject>Magnetite</subject><subject>Magnetite Nanoparticles - therapeutic use</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Nanoparticles</subject><subject>Neoplasms, Experimental - metabolism</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Neoplasms, Experimental - therapy</subject><subject>Neuroblastoma</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Obstetrics</subject><subject>Organ Specificity</subject><subject>Organs</subject><subject>Pilot Projects</subject><subject>Prostate</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aras, Omer</au><au>Pearce, Gillian</au><au>Watkins, Adam J</au><au>Nurili, Fuad</au><au>Medine, Emin Ilker</au><au>Guldu, Ozge Kozgus</au><au>Tekin, Volkan</au><au>Wong, Julian</au><au>Ma, Xianghong</au><au>Ting, Richard</au><au>Unak, Perihan</au><au>Akin, Oguz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An in-vivo pilot study into the effects of FDG-mNP in cancer in mice</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-08-20</date><risdate>2018</risdate><volume>13</volume><issue>8</issue><spage>e0202482</spage><pages>e0202482-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Previously, fluorodeoxy glucose conjugated magnetite nanoparticles (FDG-mNPs) injected into cancer cells in conjunction with the application of magnetic hyperthermia have shown promise in new FDG-mNPs applications. The aim of this study was to determine potential toxic or unwanted effects involving both tumour cells and normal tissue in other organs when FDG-mNPs are administered intravenously or intratumourally in mice.
FDG-mNPs were synthesized. A group of six prostate-tumour bearing mice were injected with 23.42 mg/ml FDG-mNPs (intravenous injection, n = 3; intratumoural injection into the prostate tumour, n = 3). Mice were euthanized and histological sampling of tissue was conducted for the prostate tumour, as well as for lungs, lymph nodes, liver, kidneys, spleen, and brain, at 1 hour (n = 2) and 7 days (n = 4) post-injection. A second group of two normal (non-cancerous) mice received the same injection intravenously into the tail vein and were euthanised at 3 and 6 months post-injection, respectively, to investigate if FDG-mNPs remained in organs at those time points.
In prostate-tumour bearing mice, FDG-mNPs concentrated in the prostate tumour, while relatively small amounts were found in the organs of other tissues, particularly the spleen and the liver; FDG-mNP concentrations decreased over time in all tissues. In normal mice, no detrimental effects were found in either mouse at 3 or 6 months.
Intravenous or intratumoural FDG-mNPs can be safely administered for effective cancer cell destruction. Further research on the clinical utility of FDG-mNPs will be conducted by applying hyperthermia in conjunction with FDG-mNPs in mice.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30125303</pmid><doi>10.1371/journal.pone.0202482</doi><orcidid>https://orcid.org/0000-0003-1758-0542</orcidid><orcidid>https://orcid.org/0000-0002-0413-9363</orcidid><orcidid>https://orcid.org/0000-0002-0264-3814</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2018-08, Vol.13 (8), p.e0202482 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2090277466 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animal tissues Animals Applied physics Biocompatibility Biology and Life Sciences Brain Breast cancer Cancer Cancer research Cancer therapies Cardiovascular disease Chemotherapy Childrens health Engineering and Technology Fever Glucose Glucose-6-Phosphate - analogs & derivatives Glucose-6-Phosphate - pharmacokinetics Glucose-6-Phosphate - pharmacology Gynecology Hyperthermia Hyperthermia, Induced Injection Intravenous administration Kidneys Liver Lungs Lymph nodes Magnetite Magnetite Nanoparticles - therapeutic use Male Medical imaging Medical research Medicine and Health Sciences Metabolism Mice Nanoparticles Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Neoplasms, Experimental - therapy Neuroblastoma NMR Nuclear magnetic resonance Obstetrics Organ Specificity Organs Pilot Projects Prostate Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Radiation therapy Research and Analysis Methods Skin cancer Spleen Studies Tumors |
| title | An in-vivo pilot study into the effects of FDG-mNP in cancer in mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T22%3A03%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20in-vivo%20pilot%20study%20into%20the%20effects%20of%20FDG-mNP%20in%20cancer%20in%20mice&rft.jtitle=PloS%20one&rft.au=Aras,%20Omer&rft.date=2018-08-20&rft.volume=13&rft.issue=8&rft.spage=e0202482&rft.pages=e0202482-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0202482&rft_dat=%3Cgale_plos_%3EA550931777%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2090277466&rft_id=info:pmid/30125303&rft_galeid=A550931777&rft_doaj_id=oai_doaj_org_article_dd9d336b133146ecaad2139aba45092d&rfr_iscdi=true |