Interaction of the human erythrocyte Band 3 anion exchanger 1 (AE1, SLC4A1) with lipids and glycophorin A: Molecular organization of the Wright (Wr) blood group antigen

The Band 3 (AE1, SLC4A1) membrane protein is found in red blood cells and in kidney where it functions as an electro-neutral chloride/bicarbonate exchanger. In this study, we have used molecular dynamics simulations to provide the first realistic model of the dimeric membrane domain of human Band 3...

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Veröffentlicht in:	PLoS computational biology 2018-07, Vol.14 (7), p.e1006284-e1006284
Hauptverfasser:	Kalli, Antreas C, Reithmeier, Reinhart A F
Format:	Artikel
Sprache:	eng
Schlagworte:	Anion Exchange Protein 1, Erythrocyte - chemistry Anion Exchange Protein 1, Erythrocyte - metabolism Anion exchanging Anions Antigens Arginine - metabolism Bands Bicarbonate Bicarbonates Binding sites Biochemistry Biology and Life Sciences Blood Blood cells Blood Group Antigens - chemistry Blood Group Antigens - metabolism Blood groups Cholesterol Cholesterol - metabolism Computer simulation Crystal structure Dimerization Dimers Erythrocytes Glutamic Acid - metabolism Glycophorin - chemistry Glycophorin - metabolism Humans Lipid Bilayers Lipids Membrane proteins Membrane Proteins - metabolism Membranes Molecular dynamics Molecular Dynamics Simulation Phosphatidylinositol Phosphatidylinositol 4,5-diphosphate Phosphatidylserine Phospholipids Phospholipids - metabolism Physical sciences Protein Binding Protein Folding Protein transport Proteins Red blood cells Simulation
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