CCL20 triggered by chemotherapy hinders the therapeutic efficacy of breast cancer

Chemotherapeutic resistance in triple-negative breast cancer (TNBC) has brought great challenges to the improvement of patient survival. The mechanisms of taxane chemoresistance in TNBC have not been well investigated. Our results illustrated C-C motif chemokine ligand 20 (CCL20) was significantly e...

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Veröffentlicht in:	PLoS biology 2018-07, Vol.16 (7), p.e2005869-e2005869
Hauptverfasser:	Chen, Weilong, Qin, Yuanyuan, Wang, Dong, Zhou, Lei, Liu, Yin, Chen, Sheng, Yin, Liang, Xiao, Yaoxing, Yao, Xiao-Hong, Yang, Xiaoli, Ma, Wei, Chen, Weifeng, He, Xueyan, Zhang, Lixing, Yang, Qifeng, Bian, Xiuwu, Shao, Zhi-Ming, Liu, Suling
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Apoptosis Biology and Life Sciences Breast cancer Cancer CCL20 protein Cell self-renewal Chemoresistance Chemotherapy Chronic illnesses Cytokines Drug therapy Efflux Feedback loops Gene expression Glycoproteins Kinases Laboratories Leukemia Life sciences Lymphoma MAP kinase MDR1 protein Medicine and Health Sciences Multidrug resistance NF-κB protein Oncology P-Glycoprotein Pathology Patient outcomes Patients Positive feedback Protein kinase Protein kinase C Proteins Research and Analysis Methods Senescence Stem cells Surgery Taxanes
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