In vitro assessment of the influence of intravenous extension set materials on insulin aspart drug delivery

Insulin is a frequently prescribed drug in hospitals and is usually administered by syringe pumps with an extension line which can be made of various materials. Two insulin solutions were studied: an insulin analogue, Novorapid® which contains insulin aspart and two phenolic preservatives (e.g. phen...

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Veröffentlicht in:	PloS one 2018-08, Vol.13 (8), p.e0201623-e0201623
Hauptverfasser:	Masse, Morgane, Maton, Mickael, Genay, Stéphanie, Blanchemain, Nicolas, Barthélémy, Christine, Décaudin, Bertrand, Odou, Pascal
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Adsorption Biochemistry Biology and Life Sciences Biomedical materials Caustic soda Chromatography Chromatography, Liquid Coextrusion Conformation Conservation Diabetes Dosage and administration Drug delivery Drug delivery systems Drug Delivery Systems - instrumentation Glycerol Humans Hydrochloric acid In Vitro Techniques Infusion Insulin Insulin Aspart - administration & dosage Insulin Aspart - chemistry Insulin pumps Insulin, Regular, Human - chemistry Intravenous administration Life Sciences Liquid chromatography Medicine and Health Sciences Pharmaceutical sciences Pharmaceuticals Pharmacology Phenolic compounds Phenols Physical Sciences Polyethylene Polyethylene - chemistry Polyethylenes Polyvinyl chloride Polyvinyl Chloride - chemistry Preservatives Proteins Sodium Sorption Studies Syringes
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