Glial responses during epileptogenesis in Mus musculus point to potential therapeutic targets

The Mesio-Temporal Lobe Epilepsy syndrome is the most common form of intractable epilepsy. It is characterized by recurrence of focal seizures and is often associated with hippocampal sclerosis and drug resistance. We aimed to characterize the molecular changes occurring during the initial stages of...

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Veröffentlicht in:	PloS one 2018-08, Vol.13 (8), p.e0201742-e0201742
Hauptverfasser:	Kalozoumi, Georgia, Kel-Margoulis, Olga, Vafiadaki, Elizabeth, Greenberg, David, Bernard, Hélène, Soreq, Hermona, Depaulis, Antoine, Sanoudou, Despina
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioinformatics Biology and Life Sciences Biomedical research Brain diseases Brain research Disease Drug resistance Epilepsy Gene expression Genes Genetic aspects Genomes Genomics Glia Hippocampus Immune response Inflammation Inflammatory response Internal medicine Medicine and Health Sciences Microglial cells Microinjection miRNA Molecular biology Morphology Neurobiology Neurochemistry Neurodegeneration Neuronal-glial interactions Neurosciences Physiological aspects Regulators Research and Analysis Methods Ribonucleic acid Risk factors RNA Rodents Sclerosis Seizures Signal transduction Studies Temporal lobe Therapeutic applications Transcription factors
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