Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor

The transcription factor Nrf2 (encoded by Nfe2l2) induces expression of numerous detoxifying and antioxidant genes in response to oxidative stress. The cytoplasmic protein Keap1 interacts with and represses Nrf2 function. Computational approaches were developed to identify factors that modulate Nrf2...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2018-08, Vol.13 (8), p.e0200004
Hauptverfasser:	Rooney, John, Oshida, Keiyu, Vasani, Naresh, Vallanat, Beena, Ryan, Natalia, Chorley, Brian N, Wang, Xuting, Bell, Douglas A, Wu, Kai C, Aleksunes, Lauren M, Klaassen, Curtis D, Kensler, Thomas W, Corton, J Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Activation Age Analysis Animal models Antioxidants Biological markers Biology and Life Sciences Biomarkers Chemical treatment Chemicals Computer applications Coupling (molecular) Dioxins Endocrinology Environmental health Ethinylestradiol Females Gender differences Gene expression Genes Growth hormone Growth hormone-releasing hormone Growth hormones Health sciences Laboratories Liver Liver cancer Males Mice Mutation NRF2 protein Organic chemistry Oxidative stress Pharmacology Pit1 protein Prophet of pit-1 protein Proteins Reactive oxygen species Research and Analysis Methods Sex differences Sex hormones Signaling Statistical tests Testosterone Toxic diseases Toxicity Toxicology Transcription factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!