Multiple birth rates of Korea and fetal/neonatal/infant mortality in multiple gestation
This study was conducted to analyze recent trends of multiple birth rates (MBR) and fetal/neonatal/infant mortalities according to the number of gestations in Korea. Data from 2009 to 2015 of live births, infant deaths and stillbirths were obtained from the Korean Vital Statistics. Neonatal mortalit...
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| description | This study was conducted to analyze recent trends of multiple birth rates (MBR) and fetal/neonatal/infant mortalities according to the number of gestations in Korea.
Data from 2009 to 2015 of live births, infant deaths and stillbirths were obtained from the Korean Vital Statistics. Neonatal mortality rate (NMR), infant mortality rate (IMR), and fetal mortality rate (FMR) in singleton, twin and triplet pregnancies were analyzed according to gestational period (GP; ≤ 23, 24-27, 28-31, and 32-36 weeks).
From 2009 to 2015, twin and triplet birth rates increased 34.5% and 154.3%, respectively. In twin births, NMR and FMR have been decreased significantly (from 10.92 to 8.62, p = 0.034 and from 41.00 to 30.55, p< 0.001, respectively), but IMR did not show significant decrease. There was no significant change of NMR, IMR, and FMR, in triplet births. Overall, in singleton, twin, and triplet births, NMR was 1.26 ± 0.09, 10.6 ± 1.12, and 34.32 ± 11.72, respectively, and IMR was 2.38 ± 0.26, 14.52 ± 1.38, and 41.13 ± 12.2, respectively. FMRs were 12 ± 1.73, 35.99 ± 3.55, and 88.85 ± 16.55, respectively, in singleton, twin, and triplet pregnancies. In spite of decreasing trends in overall mortalities, the odds ratios of NMRs and IMRs in 2015 were approximately 9-fold and 6-fold higher, respectively, in twin births, and approximately 37-fold and 20-fold higher, respectively, in triplet births, than those in singleton births. There were no significant differences in odds ratios of NMRs and IMRs at GP 32-36 among single, twin, and triplet births, although the odds ratios of FMR at GP 32-36 in triplet gestation was significantly higher than those in singleton and twin gestation.
Neonatal/infant mortality in multiple births is still significantly high, which is mainly related with preterm birth. Close fetal monitoring is needed to prevent fetal death in triplet pregnancies, after 32 gestational weeks. |
| doi_str_mv | 10.1371/journal.pone.0202318 |
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Data from 2009 to 2015 of live births, infant deaths and stillbirths were obtained from the Korean Vital Statistics. Neonatal mortality rate (NMR), infant mortality rate (IMR), and fetal mortality rate (FMR) in singleton, twin and triplet pregnancies were analyzed according to gestational period (GP; ≤ 23, 24-27, 28-31, and 32-36 weeks).
From 2009 to 2015, twin and triplet birth rates increased 34.5% and 154.3%, respectively. In twin births, NMR and FMR have been decreased significantly (from 10.92 to 8.62, p = 0.034 and from 41.00 to 30.55, p< 0.001, respectively), but IMR did not show significant decrease. There was no significant change of NMR, IMR, and FMR, in triplet births. Overall, in singleton, twin, and triplet births, NMR was 1.26 ± 0.09, 10.6 ± 1.12, and 34.32 ± 11.72, respectively, and IMR was 2.38 ± 0.26, 14.52 ± 1.38, and 41.13 ± 12.2, respectively. FMRs were 12 ± 1.73, 35.99 ± 3.55, and 88.85 ± 16.55, respectively, in singleton, twin, and triplet pregnancies. In spite of decreasing trends in overall mortalities, the odds ratios of NMRs and IMRs in 2015 were approximately 9-fold and 6-fold higher, respectively, in twin births, and approximately 37-fold and 20-fold higher, respectively, in triplet births, than those in singleton births. There were no significant differences in odds ratios of NMRs and IMRs at GP 32-36 among single, twin, and triplet births, although the odds ratios of FMR at GP 32-36 in triplet gestation was significantly higher than those in singleton and twin gestation.
Neonatal/infant mortality in multiple births is still significantly high, which is mainly related with preterm birth. Close fetal monitoring is needed to prevent fetal death in triplet pregnancies, after 32 gestational weeks.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0202318</identifier><identifier>PMID: 30110380</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Biology and Life Sciences ; Birth ; Birth rate ; Births ; Care and treatment ; Childbirth & labor ; Cohort Studies ; Female ; Fetal monitoring ; Fetal Mortality - trends ; Fetofetal transfusion ; Fetuses ; Gestation ; Health aspects ; Humans ; Infant ; Infant mortality ; Infant Mortality - trends ; Infants ; Medicine and Health Sciences ; Mortality ; Multiple Birth Offspring ; Multiple births ; Neonates ; Newborn babies ; Newborn infants ; NMR ; Nuclear magnetic resonance ; Pregnancy ; Pregnancy Outcome ; Pregnancy, Multiple ; Premature birth ; Reproductive technologies ; Republic of Korea - epidemiology ; Trends ; Twins ; Vital statistics</subject><ispartof>PloS one, 2018-08, Vol.13 (8), p.e0202318</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Ko et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Ko et al 2018 Ko et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c659t-ca7fbd9240aba3b7ba44395b2eaf132bbe7fd5ce9efd340ca5b4487bc2f931bc3</citedby><cites>FETCH-LOGICAL-c659t-ca7fbd9240aba3b7ba44395b2eaf132bbe7fd5ce9efd340ca5b4487bc2f931bc3</cites><orcidid>0000-0001-6310-6206</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093695/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093695/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30110380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ko, Hyun Sun</creatorcontrib><creatorcontrib>Wie, Jeong Ha</creatorcontrib><creatorcontrib>Choi, Sae Kyung</creatorcontrib><creatorcontrib>Park, In Yang</creatorcontrib><creatorcontrib>Park, Yong-Gyu</creatorcontrib><creatorcontrib>Shin, Jong Chul</creatorcontrib><title>Multiple birth rates of Korea and fetal/neonatal/infant mortality in multiple gestation</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study was conducted to analyze recent trends of multiple birth rates (MBR) and fetal/neonatal/infant mortalities according to the number of gestations in Korea.
Data from 2009 to 2015 of live births, infant deaths and stillbirths were obtained from the Korean Vital Statistics. Neonatal mortality rate (NMR), infant mortality rate (IMR), and fetal mortality rate (FMR) in singleton, twin and triplet pregnancies were analyzed according to gestational period (GP; ≤ 23, 24-27, 28-31, and 32-36 weeks).
From 2009 to 2015, twin and triplet birth rates increased 34.5% and 154.3%, respectively. In twin births, NMR and FMR have been decreased significantly (from 10.92 to 8.62, p = 0.034 and from 41.00 to 30.55, p< 0.001, respectively), but IMR did not show significant decrease. There was no significant change of NMR, IMR, and FMR, in triplet births. Overall, in singleton, twin, and triplet births, NMR was 1.26 ± 0.09, 10.6 ± 1.12, and 34.32 ± 11.72, respectively, and IMR was 2.38 ± 0.26, 14.52 ± 1.38, and 41.13 ± 12.2, respectively. FMRs were 12 ± 1.73, 35.99 ± 3.55, and 88.85 ± 16.55, respectively, in singleton, twin, and triplet pregnancies. In spite of decreasing trends in overall mortalities, the odds ratios of NMRs and IMRs in 2015 were approximately 9-fold and 6-fold higher, respectively, in twin births, and approximately 37-fold and 20-fold higher, respectively, in triplet births, than those in singleton births. There were no significant differences in odds ratios of NMRs and IMRs at GP 32-36 among single, twin, and triplet births, although the odds ratios of FMR at GP 32-36 in triplet gestation was significantly higher than those in singleton and twin gestation.
Neonatal/infant mortality in multiple births is still significantly high, which is mainly related with preterm birth. Close fetal monitoring is needed to prevent fetal death in triplet pregnancies, after 32 gestational weeks.</description><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Birth</subject><subject>Birth rate</subject><subject>Births</subject><subject>Care and treatment</subject><subject>Childbirth & labor</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Fetal monitoring</subject><subject>Fetal Mortality - trends</subject><subject>Fetofetal transfusion</subject><subject>Fetuses</subject><subject>Gestation</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant mortality</subject><subject>Infant Mortality - trends</subject><subject>Infants</subject><subject>Medicine and Health Sciences</subject><subject>Mortality</subject><subject>Multiple Birth Offspring</subject><subject>Multiple births</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Newborn infants</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy, Multiple</subject><subject>Premature birth</subject><subject>Reproductive technologies</subject><subject>Republic of Korea - epidemiology</subject><subject>Trends</subject><subject>Twins</subject><subject>Vital statistics</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7rr6D0QLguDFzCZNkzY3wrL4Mbiy4OdlOEmTmSxtMiapuP_ejNNZpqAguUhy8pw3h5e3KJ5itMSkwec3fgwO-uXWO71EFaoIbu8Vp5iTasEqRO4fnU-KRzHeIERJy9jD4oQgjBFp0Wnx_ePYJ7vtdSltSJsyQNKx9Kb84IOGElxXGp2gP3faO9gdrDPgUjn4kG823ZbWlcNBZK1jgmS9e1w8MNBH_WTaz4qvb998uXy_uLp-t7q8uFooRnlaKGiM7HhVI5BAZCOhrgmnstJgMKmk1I3pqNJcm47USAGVdd02UlWGEywVOSue73W3vY9i8iSKCrVt07QUt5lY7YnOw43YBjtAuBUerPhT8GEtICSrei2wbjVTSBpqcM06zTnliiHEuo5IqFjWej39NspBd0q7FKCfic5fnN2Itf8pGOKEcZoFXkwCwf8Ys1n_GHmi1pCnyob7LKYGG5W4oBQRymjbZGr5FyqvTg9W5VQYm-uzhlezhswk_SutYYxRrD5_-n_2-tucfXnEbjT0aRN9P-5yEOdgvQdV8DEGbe6cw0jsQn1wQ-xCLaZQ57Znx67fNR1STH4D8VH0AQ</recordid><startdate>20180815</startdate><enddate>20180815</enddate><creator>Ko, Hyun Sun</creator><creator>Wie, Jeong Ha</creator><creator>Choi, Sae Kyung</creator><creator>Park, In Yang</creator><creator>Park, Yong-Gyu</creator><creator>Shin, Jong Chul</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6310-6206</orcidid></search><sort><creationdate>20180815</creationdate><title>Multiple birth rates of Korea and fetal/neonatal/infant mortality in multiple gestation</title><author>Ko, Hyun Sun ; Wie, Jeong Ha ; Choi, Sae Kyung ; Park, In Yang ; Park, Yong-Gyu ; Shin, Jong Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c659t-ca7fbd9240aba3b7ba44395b2eaf132bbe7fd5ce9efd340ca5b4487bc2f931bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Birth</topic><topic>Birth rate</topic><topic>Births</topic><topic>Care and treatment</topic><topic>Childbirth & labor</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Fetal monitoring</topic><topic>Fetal Mortality - trends</topic><topic>Fetofetal transfusion</topic><topic>Fetuses</topic><topic>Gestation</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant mortality</topic><topic>Infant Mortality - trends</topic><topic>Infants</topic><topic>Medicine and Health Sciences</topic><topic>Mortality</topic><topic>Multiple Birth Offspring</topic><topic>Multiple births</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Newborn infants</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy, Multiple</topic><topic>Premature birth</topic><topic>Reproductive technologies</topic><topic>Republic of Korea - epidemiology</topic><topic>Trends</topic><topic>Twins</topic><topic>Vital statistics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ko, Hyun Sun</creatorcontrib><creatorcontrib>Wie, Jeong Ha</creatorcontrib><creatorcontrib>Choi, Sae Kyung</creatorcontrib><creatorcontrib>Park, In Yang</creatorcontrib><creatorcontrib>Park, Yong-Gyu</creatorcontrib><creatorcontrib>Shin, Jong Chul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Data from 2009 to 2015 of live births, infant deaths and stillbirths were obtained from the Korean Vital Statistics. Neonatal mortality rate (NMR), infant mortality rate (IMR), and fetal mortality rate (FMR) in singleton, twin and triplet pregnancies were analyzed according to gestational period (GP; ≤ 23, 24-27, 28-31, and 32-36 weeks).
From 2009 to 2015, twin and triplet birth rates increased 34.5% and 154.3%, respectively. In twin births, NMR and FMR have been decreased significantly (from 10.92 to 8.62, p = 0.034 and from 41.00 to 30.55, p< 0.001, respectively), but IMR did not show significant decrease. There was no significant change of NMR, IMR, and FMR, in triplet births. Overall, in singleton, twin, and triplet births, NMR was 1.26 ± 0.09, 10.6 ± 1.12, and 34.32 ± 11.72, respectively, and IMR was 2.38 ± 0.26, 14.52 ± 1.38, and 41.13 ± 12.2, respectively. FMRs were 12 ± 1.73, 35.99 ± 3.55, and 88.85 ± 16.55, respectively, in singleton, twin, and triplet pregnancies. In spite of decreasing trends in overall mortalities, the odds ratios of NMRs and IMRs in 2015 were approximately 9-fold and 6-fold higher, respectively, in twin births, and approximately 37-fold and 20-fold higher, respectively, in triplet births, than those in singleton births. There were no significant differences in odds ratios of NMRs and IMRs at GP 32-36 among single, twin, and triplet births, although the odds ratios of FMR at GP 32-36 in triplet gestation was significantly higher than those in singleton and twin gestation.
Neonatal/infant mortality in multiple births is still significantly high, which is mainly related with preterm birth. Close fetal monitoring is needed to prevent fetal death in triplet pregnancies, after 32 gestational weeks.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30110380</pmid><doi>10.1371/journal.pone.0202318</doi><tpages>e0202318</tpages><orcidid>https://orcid.org/0000-0001-6310-6206</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Biology and Life Sciences Birth Birth rate Births Care and treatment Childbirth & labor Cohort Studies Female Fetal monitoring Fetal Mortality - trends Fetofetal transfusion Fetuses Gestation Health aspects Humans Infant Infant mortality Infant Mortality - trends Infants Medicine and Health Sciences Mortality Multiple Birth Offspring Multiple births Neonates Newborn babies Newborn infants NMR Nuclear magnetic resonance Pregnancy Pregnancy Outcome Pregnancy, Multiple Premature birth Reproductive technologies Republic of Korea - epidemiology Trends Twins Vital statistics |
| title | Multiple birth rates of Korea and fetal/neonatal/infant mortality in multiple gestation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T15%3A05%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Multiple%20birth%20rates%20of%20Korea%20and%20fetal/neonatal/infant%20mortality%20in%20multiple%20gestation&rft.jtitle=PloS%20one&rft.au=Ko,%20Hyun%20Sun&rft.date=2018-08-15&rft.volume=13&rft.issue=8&rft.spage=e0202318&rft.pages=e0202318-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0202318&rft_dat=%3Cgale_plos_%3EA550356587%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2088778518&rft_id=info:pmid/30110380&rft_galeid=A550356587&rft_doaj_id=oai_doaj_org_article_1e8e6c0bf5f146de9959c6006dd3ba26&rfr_iscdi=true |