Correlation of microbiological yield with radiographic activity on chest computed tomography in cases of suspected pulmonary tuberculosis
Little is known about the correlation between microbiological yield and radiographic activity, on chest computed tomography (CT), in suspected pulmonary tuberculosis (PTB) cases, despite CT being widely used, clinically. We used multicenter retrospective data, obtained from medical records, focusing...
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| creator | Ko, Yousang Lee, Ho Young Park, Yong Bum Hong, Su Jin Shin, Jeong Hwan Choi, Seok Jin Kim, Changhwan Park, So Young Jeong, Jin Young |
| description | Little is known about the correlation between microbiological yield and radiographic activity, on chest computed tomography (CT), in suspected pulmonary tuberculosis (PTB) cases, despite CT being widely used, clinically.
We used multicenter retrospective data, obtained from medical records, focusing on the diagnostic performance for definite PTB. We categorized patients into four groups, by radiographic activity: definitely active, probably active, indeterminate activity, and probably inactive.
Of the 650 patients included, 316 had culture-confirmed PTB; 190 (29.2%), 323 (49.7%), 70 (10.8%), and 67 (10.3%) were classified into the definitely active, probably active, indeterminate activity, and probably inactive groups, respectively. The corresponding observed culture rates for CT radiographic activity were 61.6%, 60.7%, 4.3% and 0%, respectively. When not only culture rates but TB-PCR and histological results were taken into consideration as definite PTB, it showed 66.6%, 67.2%, 14.3%, and 0% of each CT radiographic activity, respectively. Regarding the diagnostic performance for definite PTB, radiographic activity displayed high sensitivity (97.1%, 95% confidence interval (CI), 94.6-98.5) and negative predictive values (92.7%, 95% CI, 86.6-96.2), considered definitely and probably active PTB. Apart from PTB, other etiologies, according to radiographic activity, were predominantly respiratory infections such as bacterial pneumonia and non-tuberculous mycobacterial infection.
Radiographic activity showed good diagnostic performance, and can be used easily in clinical practice. However, clinicians should consider other possibilities, because radiologic images do not confirm microbiological PTB. |
| doi_str_mv | 10.1371/journal.pone.0201748 |
| format | Article |
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We used multicenter retrospective data, obtained from medical records, focusing on the diagnostic performance for definite PTB. We categorized patients into four groups, by radiographic activity: definitely active, probably active, indeterminate activity, and probably inactive.
Of the 650 patients included, 316 had culture-confirmed PTB; 190 (29.2%), 323 (49.7%), 70 (10.8%), and 67 (10.3%) were classified into the definitely active, probably active, indeterminate activity, and probably inactive groups, respectively. The corresponding observed culture rates for CT radiographic activity were 61.6%, 60.7%, 4.3% and 0%, respectively. When not only culture rates but TB-PCR and histological results were taken into consideration as definite PTB, it showed 66.6%, 67.2%, 14.3%, and 0% of each CT radiographic activity, respectively. Regarding the diagnostic performance for definite PTB, radiographic activity displayed high sensitivity (97.1%, 95% confidence interval (CI), 94.6-98.5) and negative predictive values (92.7%, 95% CI, 86.6-96.2), considered definitely and probably active PTB. Apart from PTB, other etiologies, according to radiographic activity, were predominantly respiratory infections such as bacterial pneumonia and non-tuberculous mycobacterial infection.
Radiographic activity showed good diagnostic performance, and can be used easily in clinical practice. However, clinicians should consider other possibilities, because radiologic images do not confirm microbiological PTB.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0201748</identifier><identifier>PMID: 30091997</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Bacteriological Techniques ; Biology and Life Sciences ; Bronchoalveolar Lavage ; Bronchoscopy ; Calcification ; Care and treatment ; CAT scans ; Chest ; Clinical medicine ; Computation ; Computed tomography ; Confidence intervals ; Correlation ; Critical care ; Culture ; Diagnosis ; Diagnostic systems ; Etiology ; Female ; Hospitals ; Humans ; Infections ; Infectious diseases ; Internal medicine ; Laboratories ; Lung - diagnostic imaging ; Lung - microbiology ; Lung diseases ; Male ; Medical diagnosis ; Medical records ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mycobacterium tuberculosis - growth & development ; Mycobacterium tuberculosis - isolation & purification ; Patients ; Pulmonary tuberculosis ; Radiology ; Research and Analysis Methods ; Respiratory Tract Infections - diagnostic imaging ; Respiratory Tract Infections - microbiology ; Retrospective Studies ; Sensitivity and Specificity ; Studies ; Thorax - diagnostic imaging ; Tomography, X-Ray Computed ; Tuberculosis ; Tuberculosis, Pulmonary - diagnostic imaging ; Tuberculosis, Pulmonary - microbiology</subject><ispartof>PloS one, 2018-08, Vol.13 (8), p.e0201748-e0201748</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Ko et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Ko et al 2018 Ko et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-b22f5b9eeffd203f5cb88bb6e17d37514328d826e662f24ffec53bdb62db44e83</citedby><cites>FETCH-LOGICAL-c692t-b22f5b9eeffd203f5cb88bb6e17d37514328d826e662f24ffec53bdb62db44e83</cites><orcidid>0000-0003-3318-2528 ; 0000-0002-1703-6590</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084932/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084932/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30091997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cardona, Pere-Joan</contributor><creatorcontrib>Ko, Yousang</creatorcontrib><creatorcontrib>Lee, Ho Young</creatorcontrib><creatorcontrib>Park, Yong Bum</creatorcontrib><creatorcontrib>Hong, Su Jin</creatorcontrib><creatorcontrib>Shin, Jeong Hwan</creatorcontrib><creatorcontrib>Choi, Seok Jin</creatorcontrib><creatorcontrib>Kim, Changhwan</creatorcontrib><creatorcontrib>Park, So Young</creatorcontrib><creatorcontrib>Jeong, Jin Young</creatorcontrib><title>Correlation of microbiological yield with radiographic activity on chest computed tomography in cases of suspected pulmonary tuberculosis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Little is known about the correlation between microbiological yield and radiographic activity, on chest computed tomography (CT), in suspected pulmonary tuberculosis (PTB) cases, despite CT being widely used, clinically.
We used multicenter retrospective data, obtained from medical records, focusing on the diagnostic performance for definite PTB. We categorized patients into four groups, by radiographic activity: definitely active, probably active, indeterminate activity, and probably inactive.
Of the 650 patients included, 316 had culture-confirmed PTB; 190 (29.2%), 323 (49.7%), 70 (10.8%), and 67 (10.3%) were classified into the definitely active, probably active, indeterminate activity, and probably inactive groups, respectively. The corresponding observed culture rates for CT radiographic activity were 61.6%, 60.7%, 4.3% and 0%, respectively. When not only culture rates but TB-PCR and histological results were taken into consideration as definite PTB, it showed 66.6%, 67.2%, 14.3%, and 0% of each CT radiographic activity, respectively. Regarding the diagnostic performance for definite PTB, radiographic activity displayed high sensitivity (97.1%, 95% confidence interval (CI), 94.6-98.5) and negative predictive values (92.7%, 95% CI, 86.6-96.2), considered definitely and probably active PTB. Apart from PTB, other etiologies, according to radiographic activity, were predominantly respiratory infections such as bacterial pneumonia and non-tuberculous mycobacterial infection.
Radiographic activity showed good diagnostic performance, and can be used easily in clinical practice. However, clinicians should consider other possibilities, because radiologic images do not confirm microbiological PTB.</description><subject>Adult</subject><subject>Aged</subject><subject>Bacteriological Techniques</subject><subject>Biology and Life Sciences</subject><subject>Bronchoalveolar Lavage</subject><subject>Bronchoscopy</subject><subject>Calcification</subject><subject>Care and treatment</subject><subject>CAT scans</subject><subject>Chest</subject><subject>Clinical medicine</subject><subject>Computation</subject><subject>Computed tomography</subject><subject>Confidence intervals</subject><subject>Correlation</subject><subject>Critical care</subject><subject>Culture</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Etiology</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Internal medicine</subject><subject>Laboratories</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - microbiology</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mycobacterium tuberculosis - growth & development</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Patients</subject><subject>Pulmonary tuberculosis</subject><subject>Radiology</subject><subject>Research and Analysis Methods</subject><subject>Respiratory Tract Infections - diagnostic imaging</subject><subject>Respiratory Tract Infections - microbiology</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Studies</subject><subject>Thorax - diagnostic imaging</subject><subject>Tomography, X-Ray Computed</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Pulmonary - diagnostic imaging</subject><subject>Tuberculosis, Pulmonary - microbiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1trFDEUxwdRbK1-A9EBQfRh10xuk3kRyuJloVDw9hqSTLKbkpmMSaa6H8FvbaY7LbvSB8lDQvI7_3PJOUXxvALLCtXVuys_hl645eB7vQQQVDVmD4rTqkFwQSFADw_OJ8WTGK8AIIhR-rg4QQA0VdPUp8WflQ9BO5Gs70tvys6q4KX1zm-sEq7cWe3a8pdN2zKI1vpNEMPWqlKoZK9t2pXZTG11TKXy3TAm3ZbJd3tsV9r8KKKOk3Ic46DVBAyj63wvwq5Mo9RBjc5HG58Wj4xwUT-b97Pi-8cP31afFxeXn9ar84uFog1MCwmhIbLR2pg2Z2aIkoxJSXVVt6gmFUaQtQxSTSk0EBujFUGylRS2EmPN0Fnxcq87ZLd8rmLkEDAKSVMBlIn1nmi9uOJDsF2OlXth-c2FDxsuQrLKaa5w3UhBUd3gClMpBGoaVtWAaGAYYThrvZ-9jbLTrdJ9CsIdiR6_9HbLN_6aU8Bw_r4s8GYWCP7nmAvNOxuVdk702o83cdeEMYynuF_9g96f3UxtRE7A9sZnv2oS5ecENwThmpBMLe-h8mp1bpHccsbm-yODt0cGmUn6d9qIMUa-_vrl_9nLH8fs6wN2q4VL2-jdODVsPAbxHswNHGPQ5q7IFeDTxNxWg08Tw-eJyWYvDj_ozuh2RNBfZKAUZQ</recordid><startdate>20180809</startdate><enddate>20180809</enddate><creator>Ko, Yousang</creator><creator>Lee, Ho Young</creator><creator>Park, Yong Bum</creator><creator>Hong, Su Jin</creator><creator>Shin, Jeong Hwan</creator><creator>Choi, Seok Jin</creator><creator>Kim, Changhwan</creator><creator>Park, So Young</creator><creator>Jeong, Jin Young</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3318-2528</orcidid><orcidid>https://orcid.org/0000-0002-1703-6590</orcidid></search><sort><creationdate>20180809</creationdate><title>Correlation of microbiological yield with radiographic activity on chest computed tomography in cases of suspected pulmonary tuberculosis</title><author>Ko, Yousang ; Lee, Ho Young ; Park, Yong Bum ; Hong, Su Jin ; Shin, Jeong Hwan ; Choi, Seok Jin ; Kim, Changhwan ; Park, So Young ; Jeong, Jin Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-b22f5b9eeffd203f5cb88bb6e17d37514328d826e662f24ffec53bdb62db44e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bacteriological Techniques</topic><topic>Biology and Life Sciences</topic><topic>Bronchoalveolar Lavage</topic><topic>Bronchoscopy</topic><topic>Calcification</topic><topic>Care and treatment</topic><topic>CAT scans</topic><topic>Chest</topic><topic>Clinical medicine</topic><topic>Computation</topic><topic>Computed tomography</topic><topic>Confidence intervals</topic><topic>Correlation</topic><topic>Critical care</topic><topic>Culture</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Etiology</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Internal medicine</topic><topic>Laboratories</topic><topic>Lung - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ko, Yousang</au><au>Lee, Ho Young</au><au>Park, Yong Bum</au><au>Hong, Su Jin</au><au>Shin, Jeong Hwan</au><au>Choi, Seok Jin</au><au>Kim, Changhwan</au><au>Park, So Young</au><au>Jeong, Jin Young</au><au>Cardona, Pere-Joan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of microbiological yield with radiographic activity on chest computed tomography in cases of suspected pulmonary tuberculosis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-08-09</date><risdate>2018</risdate><volume>13</volume><issue>8</issue><spage>e0201748</spage><epage>e0201748</epage><pages>e0201748-e0201748</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Little is known about the correlation between microbiological yield and radiographic activity, on chest computed tomography (CT), in suspected pulmonary tuberculosis (PTB) cases, despite CT being widely used, clinically.
We used multicenter retrospective data, obtained from medical records, focusing on the diagnostic performance for definite PTB. We categorized patients into four groups, by radiographic activity: definitely active, probably active, indeterminate activity, and probably inactive.
Of the 650 patients included, 316 had culture-confirmed PTB; 190 (29.2%), 323 (49.7%), 70 (10.8%), and 67 (10.3%) were classified into the definitely active, probably active, indeterminate activity, and probably inactive groups, respectively. The corresponding observed culture rates for CT radiographic activity were 61.6%, 60.7%, 4.3% and 0%, respectively. When not only culture rates but TB-PCR and histological results were taken into consideration as definite PTB, it showed 66.6%, 67.2%, 14.3%, and 0% of each CT radiographic activity, respectively. Regarding the diagnostic performance for definite PTB, radiographic activity displayed high sensitivity (97.1%, 95% confidence interval (CI), 94.6-98.5) and negative predictive values (92.7%, 95% CI, 86.6-96.2), considered definitely and probably active PTB. Apart from PTB, other etiologies, according to radiographic activity, were predominantly respiratory infections such as bacterial pneumonia and non-tuberculous mycobacterial infection.
Radiographic activity showed good diagnostic performance, and can be used easily in clinical practice. However, clinicians should consider other possibilities, because radiologic images do not confirm microbiological PTB.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30091997</pmid><doi>10.1371/journal.pone.0201748</doi><tpages>e0201748</tpages><orcidid>https://orcid.org/0000-0003-3318-2528</orcidid><orcidid>https://orcid.org/0000-0002-1703-6590</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2086259103 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Bacteriological Techniques Biology and Life Sciences Bronchoalveolar Lavage Bronchoscopy Calcification Care and treatment CAT scans Chest Clinical medicine Computation Computed tomography Confidence intervals Correlation Critical care Culture Diagnosis Diagnostic systems Etiology Female Hospitals Humans Infections Infectious diseases Internal medicine Laboratories Lung - diagnostic imaging Lung - microbiology Lung diseases Male Medical diagnosis Medical records Medicine Medicine and Health Sciences Middle Aged Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - isolation & purification Patients Pulmonary tuberculosis Radiology Research and Analysis Methods Respiratory Tract Infections - diagnostic imaging Respiratory Tract Infections - microbiology Retrospective Studies Sensitivity and Specificity Studies Thorax - diagnostic imaging Tomography, X-Ray Computed Tuberculosis Tuberculosis, Pulmonary - diagnostic imaging Tuberculosis, Pulmonary - microbiology |
| title | Correlation of microbiological yield with radiographic activity on chest computed tomography in cases of suspected pulmonary tuberculosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T21%3A55%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20of%20microbiological%20yield%20with%20radiographic%20activity%20on%20chest%20computed%20tomography%20in%20cases%20of%20suspected%20pulmonary%20tuberculosis&rft.jtitle=PloS%20one&rft.au=Ko,%20Yousang&rft.date=2018-08-09&rft.volume=13&rft.issue=8&rft.spage=e0201748&rft.epage=e0201748&rft.pages=e0201748-e0201748&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0201748&rft_dat=%3Cgale_plos_%3EA549534755%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2086259103&rft_id=info:pmid/30091997&rft_galeid=A549534755&rft_doaj_id=oai_doaj_org_article_c479ba63794146baa39981705e0f8584&rfr_iscdi=true |