An original Eurasian haplotype, HLA-DRB114:54-DQB105:03, influences the susceptibility to idiopathic achalasia

Idiopathic achalasia is a relatively infrequent esophageal motor disorder for which major histocompatibility complex (MHC) genes are well-identified risk factors. However, no information about HLA-achalasia susceptibility in Mexicans has previously been reported. We studied a group of 91 patients di...

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Veröffentlicht in:	PloS one 2018-08, Vol.13 (8), p.e0201676-e0201676
Hauptverfasser:	Furuzawa-Carballeda, Janette, Zuñiga, Joaquín, Hernández-Zaragoza, Diana I, Barquera, Rodrigo, Marques-García, Eduardo, Jiménez-Alvarez, Luis, Cruz-Lagunas, Alfredo, Ramírez, Gustavo, Regino, Nora E, Espinosa-Soto, Ramón, Yunis, Edmond J, Romero-Hernández, Fernanda, Azamar-Llamas, Daniel, Coss-Adame, Enrique, Valdovinos, Miguel A, Torres-Landa, Samuel, Palacios-Ramírez, Axel, Breña, Blanca, Alejandro-Medrano, Edgar, Hernández-Ávila, Axel, Granados, Julio, Torres-Villalobos, Gonzalo
Format:	Artikel
Sprache:	eng
Schlagworte:	Achalasia Admixtures Alleles Analysis Antigens Biology and Life Sciences Diagnosis Disease susceptibility DNA sequencing Drb1 protein Esophagus Gastroenterology Gene frequency Genes Genetic aspects Genetic research Genetics Haplotypes Health sciences Histocompatibility antigen HLA Immunology Laboratories Lupus Major histocompatibility complex Minority & ethnic groups Patients People and places Research and Analysis Methods Rheumatology Risk analysis Risk factors Roma Romani people Short tandem repeats Statistical analysis Surgery Tissue typing Typing
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