Deficits in nominal reference identify thought disordered speech in a narrative production task
Formal thought disorder (TD) is a neuropathology manifest in formal language dysfunction, but few behavioural linguistic studies exist. These have highlighted problems in the domain of semantics and more specifically of reference. Here we aimed for a more complete and systematic linguistic model of...
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| creator | Sevilla, Gabriel Rosselló, Joana Salvador, Raymond Sarró, Salvador López-Araquistain, Laura Pomarol-Clotet, Edith Hinzen, Wolfram |
| description | Formal thought disorder (TD) is a neuropathology manifest in formal language dysfunction, but few behavioural linguistic studies exist. These have highlighted problems in the domain of semantics and more specifically of reference. Here we aimed for a more complete and systematic linguistic model of TD, focused on (i) a more in-depth analysis of anomalies of reference as depending on the grammatical construction type in which they occur, and (ii) measures of formal grammatical complexity and errors. Narrative speech obtained from 40 patients with schizophrenia, 20 with TD and 20 without, and from 14 healthy controls matched on pre-morbid IQ, was rated blindly. Results showed that of 10 linguistic variables annotated, 4 showed significant differences between groups, including the two patient groups. These all concerned mis-uses of noun phrases (NPs) for purposes of reference, but showed sensitivity to how NPs were classed: definite and pronominal forms of reference were more affected than indefinite and non-pronominal (lexical) NPs. None of the measures of formal grammatical complexity and errors distinguished groups. We conclude that TD exhibits a specific and differentiated linguistic profile, which can illuminate TD neuro-cognitively and inform future neuroimaging studies, and can have clinical utility as a linguistic biomarker. |
| doi_str_mv | 10.1371/journal.pone.0201545 |
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These have highlighted problems in the domain of semantics and more specifically of reference. Here we aimed for a more complete and systematic linguistic model of TD, focused on (i) a more in-depth analysis of anomalies of reference as depending on the grammatical construction type in which they occur, and (ii) measures of formal grammatical complexity and errors. Narrative speech obtained from 40 patients with schizophrenia, 20 with TD and 20 without, and from 14 healthy controls matched on pre-morbid IQ, was rated blindly. Results showed that of 10 linguistic variables annotated, 4 showed significant differences between groups, including the two patient groups. These all concerned mis-uses of noun phrases (NPs) for purposes of reference, but showed sensitivity to how NPs were classed: definite and pronominal forms of reference were more affected than indefinite and non-pronominal (lexical) NPs. None of the measures of formal grammatical complexity and errors distinguished groups. We conclude that TD exhibits a specific and differentiated linguistic profile, which can illuminate TD neuro-cognitively and inform future neuroimaging studies, and can have clinical utility as a linguistic biomarker.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0201545</identifier><identifier>PMID: 30086142</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Analysis ; Autism ; Biology and Life Sciences ; Biomarkers ; Cognition & reasoning ; Cognition Disorders - diagnosis ; Communication disorders ; Complexity ; Diagnosis ; Female ; Formal thought disorder ; Humans ; Language ; Language and thought ; Linguistic analysis (Linguistics) ; Linguistics ; Male ; Medical imaging ; Medicine and Health Sciences ; Memory ; Mental disorders ; Middle Aged ; Narration ; Narrative ; Neuroimaging ; Neurology ; Neuropsychological Tests ; Psychiatry ; Psychosis ; Schizophrenia ; Schizophrenia - complications ; Schizophrenic Language ; Semantics ; Social Sciences ; Speech ; Speech Disorders - diagnosis ; Studies ; Thinking</subject><ispartof>PloS one, 2018-08, Vol.13 (8), p.e0201545-e0201545</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Sevilla et al. 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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess</rights><rights>2018 Sevilla et al 2018 Sevilla et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c734t-2eb9537feca6e771f0ee59b63207a2feae26a136d691ba97c82b591f7e5b95b93</citedby><cites>FETCH-LOGICAL-c734t-2eb9537feca6e771f0ee59b63207a2feae26a136d691ba97c82b591f7e5b95b93</cites><orcidid>0000-0003-1835-2189 ; 0000-0002-7446-2983</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080774/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080774/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,26974,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30086142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Guloksuz, Sinan</contributor><creatorcontrib>Sevilla, Gabriel</creatorcontrib><creatorcontrib>Rosselló, Joana</creatorcontrib><creatorcontrib>Salvador, Raymond</creatorcontrib><creatorcontrib>Sarró, Salvador</creatorcontrib><creatorcontrib>López-Araquistain, Laura</creatorcontrib><creatorcontrib>Pomarol-Clotet, Edith</creatorcontrib><creatorcontrib>Hinzen, Wolfram</creatorcontrib><title>Deficits in nominal reference identify thought disordered speech in a narrative production task</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Formal thought disorder (TD) is a neuropathology manifest in formal language dysfunction, but few behavioural linguistic studies exist. 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We conclude that TD exhibits a specific and differentiated linguistic profile, which can illuminate TD neuro-cognitively and inform future neuroimaging studies, and can have clinical utility as a linguistic biomarker.</description><subject>Adult</subject><subject>Analysis</subject><subject>Autism</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Cognition & reasoning</subject><subject>Cognition Disorders - diagnosis</subject><subject>Communication disorders</subject><subject>Complexity</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Formal thought disorder</subject><subject>Humans</subject><subject>Language</subject><subject>Language and thought</subject><subject>Linguistic analysis (Linguistics)</subject><subject>Linguistics</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Memory</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>Narration</subject><subject>Narrative</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Psychiatry</subject><subject>Psychosis</subject><subject>Schizophrenia</subject><subject>Schizophrenia - 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Academic</collection><collection>Recercat</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sevilla, Gabriel</au><au>Rosselló, Joana</au><au>Salvador, Raymond</au><au>Sarró, Salvador</au><au>López-Araquistain, Laura</au><au>Pomarol-Clotet, Edith</au><au>Hinzen, Wolfram</au><au>Guloksuz, Sinan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deficits in nominal reference identify thought disordered speech in a narrative production task</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-08-07</date><risdate>2018</risdate><volume>13</volume><issue>8</issue><spage>e0201545</spage><epage>e0201545</epage><pages>e0201545-e0201545</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Formal thought disorder (TD) is a neuropathology manifest in formal language dysfunction, but few behavioural linguistic studies exist. These have highlighted problems in the domain of semantics and more specifically of reference. Here we aimed for a more complete and systematic linguistic model of TD, focused on (i) a more in-depth analysis of anomalies of reference as depending on the grammatical construction type in which they occur, and (ii) measures of formal grammatical complexity and errors. Narrative speech obtained from 40 patients with schizophrenia, 20 with TD and 20 without, and from 14 healthy controls matched on pre-morbid IQ, was rated blindly. Results showed that of 10 linguistic variables annotated, 4 showed significant differences between groups, including the two patient groups. These all concerned mis-uses of noun phrases (NPs) for purposes of reference, but showed sensitivity to how NPs were classed: definite and pronominal forms of reference were more affected than indefinite and non-pronominal (lexical) NPs. None of the measures of formal grammatical complexity and errors distinguished groups. We conclude that TD exhibits a specific and differentiated linguistic profile, which can illuminate TD neuro-cognitively and inform future neuroimaging studies, and can have clinical utility as a linguistic biomarker.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30086142</pmid><doi>10.1371/journal.pone.0201545</doi><tpages>e0201545</tpages><orcidid>https://orcid.org/0000-0003-1835-2189</orcidid><orcidid>https://orcid.org/0000-0002-7446-2983</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Analysis Autism Biology and Life Sciences Biomarkers Cognition & reasoning Cognition Disorders - diagnosis Communication disorders Complexity Diagnosis Female Formal thought disorder Humans Language Language and thought Linguistic analysis (Linguistics) Linguistics Male Medical imaging Medicine and Health Sciences Memory Mental disorders Middle Aged Narration Narrative Neuroimaging Neurology Neuropsychological Tests Psychiatry Psychosis Schizophrenia Schizophrenia - complications Schizophrenic Language Semantics Social Sciences Speech Speech Disorders - diagnosis Studies Thinking |
| title | Deficits in nominal reference identify thought disordered speech in a narrative production task |
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