Distinct mechanisms survey the structural integrity of HLA-B27:05 intracellularly and at the surface

HLA-B*27:05 is associated with the development of autoimmune spondyloarthropathies, but the precise causal relationship between the MHC haplotype and disease pathogenesis is yet to be elucidated. Studies focusing on the structure and cellular trafficking of HLA-B*27:05 implicate several links betwee...

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Veröffentlicht in:	PloS one 2018-08, Vol.13 (8), p.e0200811-e0200811
Hauptverfasser:	Hein, Zeynep, Borchert, Britta, Tolba Abualrous, Esam, Springer, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen presentation Antigen-presenting cells Antigens Arthritis Biology and Life Sciences Cell surface Cellular structure Chemical bonds Cytotoxicity Development and progression Disease Endoplasmic reticulum Engineering and Technology Etiology Etiology (Medicine) Histocompatibility antigen HLA HLA antigens Immunoglobulins Intracellular Life sciences Ligands Major histocompatibility complex Medicine and Health Sciences Pathogenesis Peptides Physical Sciences Proteins Quality control Research and Analysis Methods Risk factors Spondyloarthropathies Spondyloarthropathy Structural integrity
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