Urbanization as a risk factor for aortic stiffness in a cohort in India
Urbanization is associated with higher prevalence of cardiovascular disease worldwide. Aortic stiffness, as measured by carotid-femoral pulse wave velocity is a validated predictor of cardiovascular disease. Our objective was to determine the association between urbanization and carotid-femoral puls...
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| creator | Corlin, Laura Lane, Kevin J Sunderarajan, Jahnavi Chui, Kenneth K H Vijayakumar, Harivanza Krakoff, Lawrence Chandrasekaran, Anbarasi Thanikachalam, Sadagopan Brugge, Doug Thanikachalam, Mohan |
| description | Urbanization is associated with higher prevalence of cardiovascular disease worldwide. Aortic stiffness, as measured by carotid-femoral pulse wave velocity is a validated predictor of cardiovascular disease. Our objective was to determine the association between urbanization and carotid-femoral pulse wave velocity. The analysis included 6166 participants enrolled in an ongoing population-based study (mean age 42 years; 58% female) who live in an 80 × 80 km region of southern India. Multiple measures of urbanization were used and compared: 1) census designations, 2) satellite derived land cover (crops, grass, shrubs or trees as rural; built-up areas as urban), and 3) distance categories based on proximity to an urban center. The association between urbanization and carotid-femoral pulse wave velocity was tested in sex-stratified linear regression models. People residing in urban areas had significantly (p < 0.05) elevated mean carotid-femoral pulse wave velocity compared to non-urban populations after adjustment for other risk factors. There was also an inverse association between distance from the urban center and mean carotid-femoral pulse wave velocity: each 10 km increase in distance was associated with a decrease in mean carotid-femoral pulse wave velocity of 0.07 m/s (95% CI: -0.09, -0.06 m/s). The association was stronger among older participants, among smokers, and among those with other cardiovascular risk factors. Further research is needed to determine which components in the urban environment are associated with higher carotid-femoral pulse wave velocity. |
| doi_str_mv | 10.1371/journal.pone.0201036 |
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Aortic stiffness, as measured by carotid-femoral pulse wave velocity is a validated predictor of cardiovascular disease. Our objective was to determine the association between urbanization and carotid-femoral pulse wave velocity. The analysis included 6166 participants enrolled in an ongoing population-based study (mean age 42 years; 58% female) who live in an 80 × 80 km region of southern India. Multiple measures of urbanization were used and compared: 1) census designations, 2) satellite derived land cover (crops, grass, shrubs or trees as rural; built-up areas as urban), and 3) distance categories based on proximity to an urban center. The association between urbanization and carotid-femoral pulse wave velocity was tested in sex-stratified linear regression models. People residing in urban areas had significantly (p < 0.05) elevated mean carotid-femoral pulse wave velocity compared to non-urban populations after adjustment for other risk factors. There was also an inverse association between distance from the urban center and mean carotid-femoral pulse wave velocity: each 10 km increase in distance was associated with a decrease in mean carotid-femoral pulse wave velocity of 0.07 m/s (95% CI: -0.09, -0.06 m/s). The association was stronger among older participants, among smokers, and among those with other cardiovascular risk factors. Further research is needed to determine which components in the urban environment are associated with higher carotid-femoral pulse wave velocity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0201036</identifier><identifier>PMID: 30067798</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aorta ; Biology and Life Sciences ; Cardiovascular disease ; Cardiovascular diseases ; Cover crops ; Diabetes ; Earth Sciences ; Ecology and Environmental Sciences ; Engineering schools ; Environmental engineering ; Femur ; Health aspects ; Health care ; Health risk assessment ; Health risks ; Heart ; Hypertension ; Land cover ; Land use ; Medicine ; Medicine and Health Sciences ; Obesity ; Outdoor air quality ; People and Places ; Population density ; Population studies ; Public health ; Regression analysis ; Regression models ; Research and Analysis Methods ; Risk analysis ; Risk factors ; Rural areas ; Shrubs ; Social Sciences ; Stiffness ; Studies ; Urban areas ; Urban environment ; Urban environments ; Urban populations ; Urbanization ; Velocity ; Wave velocity</subject><ispartof>PloS one, 2018-08, Vol.13 (8), p.e0201036-e0201036</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Corlin et al. 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Aortic stiffness, as measured by carotid-femoral pulse wave velocity is a validated predictor of cardiovascular disease. Our objective was to determine the association between urbanization and carotid-femoral pulse wave velocity. The analysis included 6166 participants enrolled in an ongoing population-based study (mean age 42 years; 58% female) who live in an 80 × 80 km region of southern India. Multiple measures of urbanization were used and compared: 1) census designations, 2) satellite derived land cover (crops, grass, shrubs or trees as rural; built-up areas as urban), and 3) distance categories based on proximity to an urban center. The association between urbanization and carotid-femoral pulse wave velocity was tested in sex-stratified linear regression models. People residing in urban areas had significantly (p < 0.05) elevated mean carotid-femoral pulse wave velocity compared to non-urban populations after adjustment for other risk factors. 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Aortic stiffness, as measured by carotid-femoral pulse wave velocity is a validated predictor of cardiovascular disease. Our objective was to determine the association between urbanization and carotid-femoral pulse wave velocity. The analysis included 6166 participants enrolled in an ongoing population-based study (mean age 42 years; 58% female) who live in an 80 × 80 km region of southern India. Multiple measures of urbanization were used and compared: 1) census designations, 2) satellite derived land cover (crops, grass, shrubs or trees as rural; built-up areas as urban), and 3) distance categories based on proximity to an urban center. The association between urbanization and carotid-femoral pulse wave velocity was tested in sex-stratified linear regression models. People residing in urban areas had significantly (p < 0.05) elevated mean carotid-femoral pulse wave velocity compared to non-urban populations after adjustment for other risk factors. There was also an inverse association between distance from the urban center and mean carotid-femoral pulse wave velocity: each 10 km increase in distance was associated with a decrease in mean carotid-femoral pulse wave velocity of 0.07 m/s (95% CI: -0.09, -0.06 m/s). The association was stronger among older participants, among smokers, and among those with other cardiovascular risk factors. Further research is needed to determine which components in the urban environment are associated with higher carotid-femoral pulse wave velocity.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30067798</pmid><doi>10.1371/journal.pone.0201036</doi><tpages>e0201036</tpages><orcidid>https://orcid.org/0000-0002-3348-9063</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Aorta Biology and Life Sciences Cardiovascular disease Cardiovascular diseases Cover crops Diabetes Earth Sciences Ecology and Environmental Sciences Engineering schools Environmental engineering Femur Health aspects Health care Health risk assessment Health risks Heart Hypertension Land cover Land use Medicine Medicine and Health Sciences Obesity Outdoor air quality People and Places Population density Population studies Public health Regression analysis Regression models Research and Analysis Methods Risk analysis Risk factors Rural areas Shrubs Social Sciences Stiffness Studies Urban areas Urban environment Urban environments Urban populations Urbanization Velocity Wave velocity |
| title | Urbanization as a risk factor for aortic stiffness in a cohort in India |
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