Retinal Wnt signaling defect in a zebrafish fetal alcohol spectrum disorder model

Fetal alcohol spectrum disorder caused by prenatal alcohol exposure includes ocular abnormalities (microphthalmia, photoreceptor dysfunction, cataracts). Zebrafish embryos exposed to ethanol from gastrulation through somitogenesis show severe ocular defects, including microphthalmia and photorecepto...

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Veröffentlicht in:	PloS one 2018-08, Vol.13 (8), p.e0201659
Hauptverfasser:	Muralidharan, Pooja, Sarmah, Swapnalee, Marrs, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acids Alcohols Animals Basic Helix-Loop-Helix Transcription Factors - genetics Biology Biology and Life Sciences Care and treatment Cataracts Cell cycle Cell Differentiation Cell proliferation Cell Proliferation - drug effects Danio rerio Defects Differentiation (biology) Disease Models, Animal Embryo, Nonmammalian - drug effects Embryos Ethanol Ethanol - adverse effects Exposure Female Fetal Alcohol Spectrum Disorders - metabolism Fetal Alcohol Spectrum Disorders - pathology Fetal alcohol syndrome Folic acid Folic Acid - pharmacology Gastrulation Gene expression Glial cells Medicine and Health Sciences Metabolism Microphthalmia Nerve Tissue Proteins - genetics NeuroD protein Neurogenesis Neurosciences Neurotoxicity Photoreceptor Cells, Vertebrate - cytology Photoreceptor Cells, Vertebrate - drug effects Photoreceptor Cells, Vertebrate - metabolism Photoreceptors Physical Sciences Physiological aspects Pregnancy Prenatal experience Receptors, Notch - metabolism Retina Retina - drug effects Retina - metabolism Retina - pathology Retinal cells Retinal Diseases - chemically induced Retinal Diseases - metabolism Retinal Diseases - pathology Retinoic acid Rodents Signaling Social Sciences Somitogenesis Stem cells Supplements Transcription factors Tretinoin - pharmacology Vertebrates Wnt protein Wnt Signaling Pathway Zebrafish Zebrafish - embryology Zebrafish - genetics
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