Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload

Titin (TTN) Truncating variants (TTNtv) in the A-band of TTN predispose the mouse heart to systolic dysfunction when subjected to pressure-loading. However, the effects of TTNtv of the Z-disc are largely unexplored. A rat model of pressure-loaded heart is developed by trans-aortic constriction (TAC)...

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Veröffentlicht in:	PloS one 2018-07, Vol.13 (7), p.e0201498-e0201498
Hauptverfasser:	Ye, Lei, Su, Liping, Wang, Chenxu, Loo, Szejie, Tee, Guizhen, Tan, Shihua, Khin, Sandar Win, Ko, Shijie, Su, Boyang, Cook, Stuart A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Apoptosis Biology and Life Sciences Cardiomyopathy Carotid arteries Collagen Connectin Coronary vessels Echocardiography Fibrosis Genetic aspects Genetic variation Heart Heart diseases Heart failure Histology Hypertension Medicine and Health Sciences Ostomy Phenotypes Pressure Pressure effects Rarefaction Rats Research and Analysis Methods Rodents Surgery Veins & arteries Ventricle
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