Sika deer antler as a novel model to investigate dental implant healing: A pilot experimental study
Dental implants are important tools for restoring the loss of teeth. The rapid growth and periodic regeneration of antlers make Sika deer a good and less invasive alternative model for studying bone remodelling in mammals. We developed a special loading device for antlers and analysed the bone react...
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| Veröffentlicht in: | PloS one 2018-07, Vol.13 (7), p.e0200957-e0200957 |
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| creator | He, Yun Fischer, Dominik Hasan, Istabrak Götz, Werner Keilig, Ludger Ziegler, Luisa Abboud, Markus Bourauel, Christoph Wahl, Gerhard |
| description | Dental implants are important tools for restoring the loss of teeth. The rapid growth and periodic regeneration of antlers make Sika deer a good and less invasive alternative model for studying bone remodelling in mammals. We developed a special loading device for antlers and analysed the bone reaction around unloaded implants and under immediate loading conditions until osseointegration occurred. In micro-computed tomography images, the density of antler tissue around the implants increased as the loading time increased. This finding was histologically confirmed by the good osseointegration observed in unloaded and loaded specimens. Antler tissue displays a similar healing process to human bone. The use of an antler model is a promising alternative for implant studies that does not require animal sacrifice. |
| doi_str_mv | 10.1371/journal.pone.0200957 |
| format | Article |
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The rapid growth and periodic regeneration of antlers make Sika deer a good and less invasive alternative model for studying bone remodelling in mammals. We developed a special loading device for antlers and analysed the bone reaction around unloaded implants and under immediate loading conditions until osseointegration occurred. In micro-computed tomography images, the density of antler tissue around the implants increased as the loading time increased. This finding was histologically confirmed by the good osseointegration observed in unloaded and loaded specimens. Antler tissue displays a similar healing process to human bone. The use of an antler model is a promising alternative for implant studies that does not require animal sacrifice.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0200957</identifier><identifier>PMID: 30063761</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Antlers ; Antlers - diagnostic imaging ; Antlers - physiology ; Behavior, Animal ; Biology and Life Sciences ; Biomaterials ; Biomechanical Phenomena ; Biomechanics ; Bone Density ; Bone healing ; Bone implants ; Bone remodeling ; Bones ; CAT scans ; Cement ; Cervus nippon ; Computed tomography ; Deer ; Deer - anatomy & histology ; Dental Implants ; Dental prosthetics ; Dental restorative materials ; Dentistry ; Fractures ; Healing ; Health aspects ; Loading ; Male ; Materials science ; Mechanical loading ; Mechanical properties ; Medicine and Health Sciences ; Osseointegration ; Physiological aspects ; Pilot Projects ; Prostheses ; Regeneration ; Research and Analysis Methods ; Sika deer ; Surgical implants ; Teeth ; Transplants & implants ; Weight-Bearing ; Wound Healing ; X-Ray Microtomography</subject><ispartof>PloS one, 2018-07, Vol.13 (7), p.e0200957-e0200957</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 He et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 He et al 2018 He et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-945191ea7acd55408137da8ee83e8f2afdb5870c2c8985229d6d9f4bb834ebde3</citedby><cites>FETCH-LOGICAL-c692t-945191ea7acd55408137da8ee83e8f2afdb5870c2c8985229d6d9f4bb834ebde3</cites><orcidid>0000-0001-7334-6705 ; 0000-0002-4012-6279</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067741/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067741/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30063761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Yun</creatorcontrib><creatorcontrib>Fischer, Dominik</creatorcontrib><creatorcontrib>Hasan, Istabrak</creatorcontrib><creatorcontrib>Götz, Werner</creatorcontrib><creatorcontrib>Keilig, Ludger</creatorcontrib><creatorcontrib>Ziegler, Luisa</creatorcontrib><creatorcontrib>Abboud, Markus</creatorcontrib><creatorcontrib>Bourauel, Christoph</creatorcontrib><creatorcontrib>Wahl, Gerhard</creatorcontrib><title>Sika deer antler as a novel model to investigate dental implant healing: A pilot experimental study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Dental implants are important tools for restoring the loss of teeth. The rapid growth and periodic regeneration of antlers make Sika deer a good and less invasive alternative model for studying bone remodelling in mammals. We developed a special loading device for antlers and analysed the bone reaction around unloaded implants and under immediate loading conditions until osseointegration occurred. In micro-computed tomography images, the density of antler tissue around the implants increased as the loading time increased. This finding was histologically confirmed by the good osseointegration observed in unloaded and loaded specimens. Antler tissue displays a similar healing process to human bone. The use of an antler model is a promising alternative for implant studies that does not require animal sacrifice.</description><subject>Animals</subject><subject>Antlers</subject><subject>Antlers - diagnostic imaging</subject><subject>Antlers - physiology</subject><subject>Behavior, Animal</subject><subject>Biology and Life Sciences</subject><subject>Biomaterials</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics</subject><subject>Bone Density</subject><subject>Bone healing</subject><subject>Bone implants</subject><subject>Bone remodeling</subject><subject>Bones</subject><subject>CAT scans</subject><subject>Cement</subject><subject>Cervus nippon</subject><subject>Computed tomography</subject><subject>Deer</subject><subject>Deer - anatomy & histology</subject><subject>Dental Implants</subject><subject>Dental prosthetics</subject><subject>Dental restorative 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implants are important tools for restoring the loss of teeth. The rapid growth and periodic regeneration of antlers make Sika deer a good and less invasive alternative model for studying bone remodelling in mammals. We developed a special loading device for antlers and analysed the bone reaction around unloaded implants and under immediate loading conditions until osseointegration occurred. In micro-computed tomography images, the density of antler tissue around the implants increased as the loading time increased. This finding was histologically confirmed by the good osseointegration observed in unloaded and loaded specimens. Antler tissue displays a similar healing process to human bone. The use of an antler model is a promising alternative for implant studies that does not require animal sacrifice.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30063761</pmid><doi>10.1371/journal.pone.0200957</doi><orcidid>https://orcid.org/0000-0001-7334-6705</orcidid><orcidid>https://orcid.org/0000-0002-4012-6279</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Antlers Antlers - diagnostic imaging Antlers - physiology Behavior, Animal Biology and Life Sciences Biomaterials Biomechanical Phenomena Biomechanics Bone Density Bone healing Bone implants Bone remodeling Bones CAT scans Cement Cervus nippon Computed tomography Deer Deer - anatomy & histology Dental Implants Dental prosthetics Dental restorative materials Dentistry Fractures Healing Health aspects Loading Male Materials science Mechanical loading Mechanical properties Medicine and Health Sciences Osseointegration Physiological aspects Pilot Projects Prostheses Regeneration Research and Analysis Methods Sika deer Surgical implants Teeth Transplants & implants Weight-Bearing Wound Healing X-Ray Microtomography |
| title | Sika deer antler as a novel model to investigate dental implant healing: A pilot experimental study |
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