Development of monoclonal anti-PDGF-CC antibodies as tools for investigating human tissue expression and for blocking PDGF-CC induced PDGFRα signalling in vivo

PDGF-CC is a member of the platelet-derived growth factor (PDGF) family that stimulates PDGFRα phosphorylation and thereby activates intracellular signalling events essential for development but also in cancer, fibrosis and neuropathologies involving blood-brain barrier (BBB) disruption. In order to...

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Veröffentlicht in:	PloS one 2018, Vol.13 (7), p.e0201089
Hauptverfasser:	Li, Hong, Zeitelhofer, Manuel, Nilsson, Ingrid, Liu, Xicong, Allan, Laura, Gloria, Benjamin, Perani, Angelo, Murone, Carmel, Catimel, Bruno, Neville, A Munro, Scott, Fiona E, Scott, Andrew M, Eriksson, Ulf
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Affinity Animals Antibodies, Monoclonal - immunology Biochemistry Biology and Life Sciences Biophysics Blood platelets Blood-brain barrier Blood-Retinal Barrier - drug effects Blood-Retinal Barrier - metabolism Blood-Retinal Barrier - pathology Brain research Breast cancer Cancer Capillary Permeability Complementarity Diabetic retinopathy Epitopes Fibroblasts Fibrosis Gene Expression - drug effects Growth factors Humans Immunoglobulins Immunohistochemistry Intracellular signalling Lymphokines - antagonists & inhibitors Lymphokines - immunology Medical research Medicine Medicine and Health Sciences Mice, Inbred C57BL Mice, Transgenic Monoclonal antibodies Neoplasms - metabolism Neoplasms - pathology Newton-John, Olivia Phosphorylation Platelet-derived growth factor Platelet-Derived Growth Factor - antagonists & inhibitors Platelet-Derived Growth Factor - immunology Receptor, Platelet-Derived Growth Factor alpha - metabolism Recombinant Proteins - immunology Research and Analysis Methods Retina Rodents Signal Transduction - drug effects Tumors
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