Analysis of NFATc1 amplification in T cells for pharmacodynamic monitoring of tacrolimus in kidney transplant recipients

Therapeutic drug monitoring (TDM) of tacrolimus, based on blood concentrations, shows an imperfect correlation with the occurrence of rejection. Here, we tested whether measuring NFATc1 amplification, a member of the calcineurin pathway, is suitable for TDM of tacrolimus. NFATc1 amplification was mo...

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Veröffentlicht in:	PloS one 2018-07, Vol.13 (7), p.e0201113-e0201113
Hauptverfasser:	Kannegieter, Nynke M, Hesselink, Dennis A, Dieterich, Marjolein, de Graav, Gretchen N, Kraaijeveld, Rens, Baan, Carla C
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept - therapeutic use Adult Aged Amplification Biological effects Biology and Life Sciences Biomarkers, Pharmacological - blood Biomonitoring Blood Calcineurin CD28 antigen CD4 antigen CD8 antigen Cells, Cultured Cytokines Dosage and administration Dose-Response Relationship, Drug Drug dosages Drug monitoring Female Gene expression Graft rejection Health aspects Humans Immunosuppressive agents Immunosuppressive Agents - therapeutic use Inhibition Internal medicine Kidney Transplantation Kidney transplants Kidneys Lymphocytes Lymphocytes T Male Medicine Medicine and Health Sciences Middle Aged Mycophenolate mofetil Mycophenolic acid Nephrology NFATC Transcription Factors - blood Organ transplant recipients Patients Pharmacodynamics Pharmacology Phosphatase Research and Analysis Methods T cell receptors T cells T-Lymphocytes - drug effects T-Lymphocytes - metabolism Tacrolimus Tacrolimus - therapeutic use Therapeutic drug monitoring Transcription factors Transplant Recipients Transplantation Transplants & implants Young Adult
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