The Cow Milk Symptom Score (CoMiSSTM) in presumed healthy infants
The Cow's Milk-related Symptom Score (CoMiSSTM) was developed as an awareness tool to recognize possible manifestations of cow's milk protein allergy (CMPA). Arbitrarily, a cut-off value of ≥12 was defined as a "positive score." The aim of this study was to determine an age-relat...
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| Veröffentlicht in: | PloS one 2018-07, Vol.13 (7), p.e0200603-e0200603 |
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| creator | Vandenplas, Yvan Salvatore, Silvia Ribes-Koninckx, Carmen Carvajal, Eva Szajewska, Hania Huysentruyt, Koen |
| description | The Cow's Milk-related Symptom Score (CoMiSSTM) was developed as an awareness tool to recognize possible manifestations of cow's milk protein allergy (CMPA). Arbitrarily, a cut-off value of ≥12 was defined as a "positive score." The aim of this study was to determine an age-related CoMiSS in healthy infants to minimize the risk of false reassurance or over-diagnosis of CMPA in case of a negative or positive score, respectively.
General pediatricians determined the CoMiSS in presumed healthy infants aged ≤6 months during a routine visit. Exclusion criteria included any known acute or chronic disease, preterm delivery (< 37 weeks), therapeutic formula, any food supplement (except vitamins) or medication.
Data from 891 consecutive infants were collected. Complete information was obtained from only 413 (46.4%) infants: Belgium: 31.2%, Italy 18.2%, Poland 19.1% and Spain 31.5%. Since gender (girls vs boys) (p = 0.579) had no influence on the CoMiSS, the data were re-calculated to include those infants with missing gender. The overall median and mean (SD) CoMiSS scores were, respectively, 3.0 and 3.7 (2.9). The 95th percentile was 9. Median crying (p |
| doi_str_mv | 10.1371/journal.pone.0200603 |
| format | Article |
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General pediatricians determined the CoMiSS in presumed healthy infants aged ≤6 months during a routine visit. Exclusion criteria included any known acute or chronic disease, preterm delivery (< 37 weeks), therapeutic formula, any food supplement (except vitamins) or medication.
Data from 891 consecutive infants were collected. Complete information was obtained from only 413 (46.4%) infants: Belgium: 31.2%, Italy 18.2%, Poland 19.1% and Spain 31.5%. Since gender (girls vs boys) (p = 0.579) had no influence on the CoMiSS, the data were re-calculated to include those infants with missing gender. The overall median and mean (SD) CoMiSS scores were, respectively, 3.0 and 3.7 (2.9). The 95th percentile was 9. Median crying (p<0.001), regurgitation (p = 0.009) and eczema (p = 0.039) scores differed significantly across the age categories. The other components of the CoMiSS were not age dependent.
In healthy infants ≤ 6 months, the median CoMiSS is 3.0. More prospective studies in different sites and comparing healthy and allergic infants are warranted to obtain further evidence on the utility of the CoMiSS.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0200603</identifier><identifier>PMID: 30020980</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Age Factors ; Allergies ; Biology and Life Sciences ; Chronic illnesses ; Cow's milk ; Cross-Sectional Studies ; Data collection ; Dietary supplements ; Eczema ; Ethics ; Europe - epidemiology ; Female ; Food allergies ; Gender ; Girls ; Health aspects ; Humans ; Hypersensitivity ; Infant ; Infant, Newborn ; Infants ; Male ; Medicine and Health Sciences ; Milk ; Milk Hypersensitivity - diagnosis ; Milk Hypersensitivity - epidemiology ; Nutrition research ; Pediatric allergy ; Pediatrics ; People and Places ; Properties ; Proteins ; Regurgitation ; Risk factors ; Risk reduction ; Skin diseases ; Statistical analysis ; Systematic review ; Vitamins</subject><ispartof>PloS one, 2018-07, Vol.13 (7), p.e0200603-e0200603</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Vandenplas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Vandenplas et al 2018 Vandenplas et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-d32ade62c889224b7d1016716aae96462e506fbd9c00124d289cbfdf4edf5633</citedby><cites>FETCH-LOGICAL-c593t-d32ade62c889224b7d1016716aae96462e506fbd9c00124d289cbfdf4edf5633</cites><orcidid>0000-0002-1862-8651</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051613/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051613/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30020980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vandenplas, Yvan</creatorcontrib><creatorcontrib>Salvatore, Silvia</creatorcontrib><creatorcontrib>Ribes-Koninckx, Carmen</creatorcontrib><creatorcontrib>Carvajal, Eva</creatorcontrib><creatorcontrib>Szajewska, Hania</creatorcontrib><creatorcontrib>Huysentruyt, Koen</creatorcontrib><title>The Cow Milk Symptom Score (CoMiSSTM) in presumed healthy infants</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The Cow's Milk-related Symptom Score (CoMiSSTM) was developed as an awareness tool to recognize possible manifestations of cow's milk protein allergy (CMPA). Arbitrarily, a cut-off value of ≥12 was defined as a "positive score." The aim of this study was to determine an age-related CoMiSS in healthy infants to minimize the risk of false reassurance or over-diagnosis of CMPA in case of a negative or positive score, respectively.
General pediatricians determined the CoMiSS in presumed healthy infants aged ≤6 months during a routine visit. Exclusion criteria included any known acute or chronic disease, preterm delivery (< 37 weeks), therapeutic formula, any food supplement (except vitamins) or medication.
Data from 891 consecutive infants were collected. Complete information was obtained from only 413 (46.4%) infants: Belgium: 31.2%, Italy 18.2%, Poland 19.1% and Spain 31.5%. Since gender (girls vs boys) (p = 0.579) had no influence on the CoMiSS, the data were re-calculated to include those infants with missing gender. The overall median and mean (SD) CoMiSS scores were, respectively, 3.0 and 3.7 (2.9). The 95th percentile was 9. Median crying (p<0.001), regurgitation (p = 0.009) and eczema (p = 0.039) scores differed significantly across the age categories. The other components of the CoMiSS were not age dependent.
In healthy infants ≤ 6 months, the median CoMiSS is 3.0. More prospective studies in different sites and comparing healthy and allergic infants are warranted to obtain further evidence on the utility of the CoMiSS.</description><subject>Age</subject><subject>Age Factors</subject><subject>Allergies</subject><subject>Biology and Life Sciences</subject><subject>Chronic illnesses</subject><subject>Cow's milk</subject><subject>Cross-Sectional Studies</subject><subject>Data collection</subject><subject>Dietary supplements</subject><subject>Eczema</subject><subject>Ethics</subject><subject>Europe - epidemiology</subject><subject>Female</subject><subject>Food allergies</subject><subject>Gender</subject><subject>Girls</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Milk</subject><subject>Milk Hypersensitivity - diagnosis</subject><subject>Milk Hypersensitivity - epidemiology</subject><subject>Nutrition research</subject><subject>Pediatric allergy</subject><subject>Pediatrics</subject><subject>People and Places</subject><subject>Properties</subject><subject>Proteins</subject><subject>Regurgitation</subject><subject>Risk factors</subject><subject>Risk reduction</subject><subject>Skin diseases</subject><subject>Statistical analysis</subject><subject>Systematic review</subject><subject>Vitamins</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUl1v0zAUjRCIjcE_QBCJl_HQcm3Hdvwyqar4mLSKh_bdcmyndUniYieg_nucNZtWNPnB1vU5595zdbLsPYI5Ihx92fshdKqZH3xn54ABGJAX2SUSBM8YBvLyyfsiexPjHoCSkrHX2QWBRBAlXGaLzc7mS_83X7nmV74-tofet_la-2Dz66VfufV6s_qcuy4_BBuH1pp8Z1XT746pVquuj2-zV7Vqon033VfZ5tvXzfLH7O7n99vl4m6mqSD9zBCsjGVYl6XAuKi4QYAYR0wpK1jBsKXA6soIDYBwYXApdFWburCmpoyQq-zjSfbQ-Cgn81Fi4IgWnGOeELcnhPFqLw_BtSocpVdO3hd82EoVeqcbK5EhXBBFOC3KAkTaRMGxqigCQTTCNmndTN2GKnnWtuuDas5Ez386t5Nb_0cyoIihcdzrSSD434ONvWxd1LZpVGf9cD83RiWjgBL003_Q591NqK1KBtLufeqrR1G5oAUTqMRkbDt_BpWOsa3TKSm1S_UzQnEi6OBjDLZ-9IhAjjl7GEaOOZNTzhLtw9P9PJIegkX-ASFbzBE</recordid><startdate>20180718</startdate><enddate>20180718</enddate><creator>Vandenplas, Yvan</creator><creator>Salvatore, Silvia</creator><creator>Ribes-Koninckx, Carmen</creator><creator>Carvajal, Eva</creator><creator>Szajewska, Hania</creator><creator>Huysentruyt, Koen</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1862-8651</orcidid></search><sort><creationdate>20180718</creationdate><title>The Cow Milk Symptom Score (CoMiSSTM) in presumed healthy infants</title><author>Vandenplas, Yvan ; Salvatore, Silvia ; Ribes-Koninckx, Carmen ; Carvajal, Eva ; Szajewska, Hania ; Huysentruyt, Koen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-d32ade62c889224b7d1016716aae96462e506fbd9c00124d289cbfdf4edf5633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Age Factors</topic><topic>Allergies</topic><topic>Biology and Life Sciences</topic><topic>Chronic illnesses</topic><topic>Cow's milk</topic><topic>Cross-Sectional Studies</topic><topic>Data collection</topic><topic>Dietary supplements</topic><topic>Eczema</topic><topic>Ethics</topic><topic>Europe - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vandenplas, Yvan</au><au>Salvatore, Silvia</au><au>Ribes-Koninckx, Carmen</au><au>Carvajal, Eva</au><au>Szajewska, Hania</au><au>Huysentruyt, Koen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Cow Milk Symptom Score (CoMiSSTM) in presumed healthy infants</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-07-18</date><risdate>2018</risdate><volume>13</volume><issue>7</issue><spage>e0200603</spage><epage>e0200603</epage><pages>e0200603-e0200603</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The Cow's Milk-related Symptom Score (CoMiSSTM) was developed as an awareness tool to recognize possible manifestations of cow's milk protein allergy (CMPA). Arbitrarily, a cut-off value of ≥12 was defined as a "positive score." The aim of this study was to determine an age-related CoMiSS in healthy infants to minimize the risk of false reassurance or over-diagnosis of CMPA in case of a negative or positive score, respectively.
General pediatricians determined the CoMiSS in presumed healthy infants aged ≤6 months during a routine visit. Exclusion criteria included any known acute or chronic disease, preterm delivery (< 37 weeks), therapeutic formula, any food supplement (except vitamins) or medication.
Data from 891 consecutive infants were collected. Complete information was obtained from only 413 (46.4%) infants: Belgium: 31.2%, Italy 18.2%, Poland 19.1% and Spain 31.5%. Since gender (girls vs boys) (p = 0.579) had no influence on the CoMiSS, the data were re-calculated to include those infants with missing gender. The overall median and mean (SD) CoMiSS scores were, respectively, 3.0 and 3.7 (2.9). The 95th percentile was 9. Median crying (p<0.001), regurgitation (p = 0.009) and eczema (p = 0.039) scores differed significantly across the age categories. The other components of the CoMiSS were not age dependent.
In healthy infants ≤ 6 months, the median CoMiSS is 3.0. More prospective studies in different sites and comparing healthy and allergic infants are warranted to obtain further evidence on the utility of the CoMiSS.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30020980</pmid><doi>10.1371/journal.pone.0200603</doi><orcidid>https://orcid.org/0000-0002-1862-8651</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Age Factors Allergies Biology and Life Sciences Chronic illnesses Cow's milk Cross-Sectional Studies Data collection Dietary supplements Eczema Ethics Europe - epidemiology Female Food allergies Gender Girls Health aspects Humans Hypersensitivity Infant Infant, Newborn Infants Male Medicine and Health Sciences Milk Milk Hypersensitivity - diagnosis Milk Hypersensitivity - epidemiology Nutrition research Pediatric allergy Pediatrics People and Places Properties Proteins Regurgitation Risk factors Risk reduction Skin diseases Statistical analysis Systematic review Vitamins |
| title | The Cow Milk Symptom Score (CoMiSSTM) in presumed healthy infants |
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