Signs of continental ancestry in urban populations of Peru through autosomal STR loci and mitochondrial DNA typing
The human genetic diversity around the world was studied through several high variable genetic markers. In South America the demic consequences of admixture events between Native people, European colonists and African slaves have been displayed by uniparental markers variability. The mitochondrial D...
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| description | The human genetic diversity around the world was studied through several high variable genetic markers. In South America the demic consequences of admixture events between Native people, European colonists and African slaves have been displayed by uniparental markers variability. The mitochondrial DNA (mtDNA) has been the most widely used genetic marker for studying American mixed populations, although nuclear markers, such as microsatellite loci (STRs) commonly used in forensic science, showed to be genetically and geographically structured. In this work, we analyzed DNA from buccal swab samples of 296 individuals across Peru: 156 Native Amazons (Ashaninka, Cashibo and Shipibo from Ucayali, Huambiza from Loreto and Moche from Lambayeque) and 140 urban Peruvians from Lima and other 33 urban areas. The aim was to evaluate, through STRs and mtDNA variability, recent migrations in urban Peruvian populations and to gain more information about their continental ancestry. STR data highlighted that most individuals (67%) of the urban Peruvian sample have a strong similarity to the Amazon Native population, whereas 22% have similarity to African populations and only ~1% to European populations. Also the maternally-transmitted mtDNA confirmed the strong Native contribution (~90% of Native American haplogroups) and the lower frequencies of African (~6%) and European (~3%) haplogroups. This study provides a detailed description of the urban Peruvian genetic structure and proposes forensic STRs as a useful tool for studying recent migrations, especially when coupled with mtDNA. |
| doi_str_mv | 10.1371/journal.pone.0200796 |
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In South America the demic consequences of admixture events between Native people, European colonists and African slaves have been displayed by uniparental markers variability. The mitochondrial DNA (mtDNA) has been the most widely used genetic marker for studying American mixed populations, although nuclear markers, such as microsatellite loci (STRs) commonly used in forensic science, showed to be genetically and geographically structured. In this work, we analyzed DNA from buccal swab samples of 296 individuals across Peru: 156 Native Amazons (Ashaninka, Cashibo and Shipibo from Ucayali, Huambiza from Loreto and Moche from Lambayeque) and 140 urban Peruvians from Lima and other 33 urban areas. The aim was to evaluate, through STRs and mtDNA variability, recent migrations in urban Peruvian populations and to gain more information about their continental ancestry. STR data highlighted that most individuals (67%) of the urban Peruvian sample have a strong similarity to the Amazon Native population, whereas 22% have similarity to African populations and only ~1% to European populations. Also the maternally-transmitted mtDNA confirmed the strong Native contribution (~90% of Native American haplogroups) and the lower frequencies of African (~6%) and European (~3%) haplogroups. This study provides a detailed description of the urban Peruvian genetic structure and proposes forensic STRs as a useful tool for studying recent migrations, especially when coupled with mtDNA.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0200796</identifier><identifier>PMID: 30020992</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Admixtures ; African Americans ; Animals ; Biology ; Biology and life sciences ; CRISPR-Cas Systems ; Deoxyribonucleic acid ; DNA ; DNA Fingerprinting - methods ; DNA, Mitochondrial - genetics ; Earth Sciences ; Forensic engineering ; Forensic science ; Forensic sciences ; Genetic diversity ; Genetic markers ; Genetic research ; Genetic structure ; Genetic Variation - genetics ; Genetic Variation - physiology ; Genetics, Population - methods ; Genomes ; Haplotypes ; Haplotypes - genetics ; Haplotypes - physiology ; HeLa Cells ; Hep G2 Cells ; Humans ; Indigenous peoples ; Loci ; Markers ; Methods ; Mice ; Minority & ethnic groups ; Mitochondria ; Mitochondrial DNA ; People and Places ; Peru ; Population ; Populations ; Protein-Serine-Threonine Kinases - genetics ; Protein-Serine-Threonine Kinases - metabolism ; Real-Time Polymerase Chain Reaction ; RNA Interference ; Short tandem repeats ; Similarity ; TOR Serine-Threonine Kinases - genetics ; TOR Serine-Threonine Kinases - metabolism ; Typing ; Urban areas ; Urban Population ; Urban populations ; Variability</subject><ispartof>PloS one, 2018-07, Vol.13 (7), p.e0200796-e0200796</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Messina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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In South America the demic consequences of admixture events between Native people, European colonists and African slaves have been displayed by uniparental markers variability. The mitochondrial DNA (mtDNA) has been the most widely used genetic marker for studying American mixed populations, although nuclear markers, such as microsatellite loci (STRs) commonly used in forensic science, showed to be genetically and geographically structured. In this work, we analyzed DNA from buccal swab samples of 296 individuals across Peru: 156 Native Amazons (Ashaninka, Cashibo and Shipibo from Ucayali, Huambiza from Loreto and Moche from Lambayeque) and 140 urban Peruvians from Lima and other 33 urban areas. The aim was to evaluate, through STRs and mtDNA variability, recent migrations in urban Peruvian populations and to gain more information about their continental ancestry. 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This study provides a detailed description of the urban Peruvian genetic structure and proposes forensic STRs as a useful tool for studying recent migrations, especially when coupled with mtDNA.</description><subject>Admixtures</subject><subject>African Americans</subject><subject>Animals</subject><subject>Biology</subject><subject>Biology and life sciences</subject><subject>CRISPR-Cas Systems</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Fingerprinting - methods</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Earth Sciences</subject><subject>Forensic engineering</subject><subject>Forensic science</subject><subject>Forensic sciences</subject><subject>Genetic diversity</subject><subject>Genetic markers</subject><subject>Genetic research</subject><subject>Genetic structure</subject><subject>Genetic Variation - genetics</subject><subject>Genetic Variation - physiology</subject><subject>Genetics, Population - 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metabolism</subject><subject>Typing</subject><subject>Urban areas</subject><subject>Urban Population</subject><subject>Urban 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of continental ancestry in urban populations of Peru through autosomal STR loci and mitochondrial DNA typing</title><author>Messina, Francesco ; Di Corcia, Tullia ; Ragazzo, Michele ; Sanchez Mellado, Cesar ; Contini, Irene ; Malaspina, Patrizia ; Ciminelli, Bianca Maria ; Rickards, Olga ; Jodice, Carla</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-36336371afb37135120f765f5509656b265a121d091144048fefc3b6a7269c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Admixtures</topic><topic>African Americans</topic><topic>Animals</topic><topic>Biology</topic><topic>Biology and life sciences</topic><topic>CRISPR-Cas Systems</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Fingerprinting - methods</topic><topic>DNA, Mitochondrial - genetics</topic><topic>Earth Sciences</topic><topic>Forensic engineering</topic><topic>Forensic 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Carla</au><au>Achilli, Alessandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Signs of continental ancestry in urban populations of Peru through autosomal STR loci and mitochondrial DNA typing</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-07-18</date><risdate>2018</risdate><volume>13</volume><issue>7</issue><spage>e0200796</spage><epage>e0200796</epage><pages>e0200796-e0200796</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The human genetic diversity around the world was studied through several high variable genetic markers. In South America the demic consequences of admixture events between Native people, European colonists and African slaves have been displayed by uniparental markers variability. The mitochondrial DNA (mtDNA) has been the most widely used genetic marker for studying American mixed populations, although nuclear markers, such as microsatellite loci (STRs) commonly used in forensic science, showed to be genetically and geographically structured. In this work, we analyzed DNA from buccal swab samples of 296 individuals across Peru: 156 Native Amazons (Ashaninka, Cashibo and Shipibo from Ucayali, Huambiza from Loreto and Moche from Lambayeque) and 140 urban Peruvians from Lima and other 33 urban areas. The aim was to evaluate, through STRs and mtDNA variability, recent migrations in urban Peruvian populations and to gain more information about their continental ancestry. STR data highlighted that most individuals (67%) of the urban Peruvian sample have a strong similarity to the Amazon Native population, whereas 22% have similarity to African populations and only ~1% to European populations. Also the maternally-transmitted mtDNA confirmed the strong Native contribution (~90% of Native American haplogroups) and the lower frequencies of African (~6%) and European (~3%) haplogroups. This study provides a detailed description of the urban Peruvian genetic structure and proposes forensic STRs as a useful tool for studying recent migrations, especially when coupled with mtDNA.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30020992</pmid><doi>10.1371/journal.pone.0200796</doi><orcidid>https://orcid.org/0000-0001-8076-7217</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Directory of Open Access Journals; Public Library of Science; PubMed Central; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Admixtures African Americans Animals Biology Biology and life sciences CRISPR-Cas Systems Deoxyribonucleic acid DNA DNA Fingerprinting - methods DNA, Mitochondrial - genetics Earth Sciences Forensic engineering Forensic science Forensic sciences Genetic diversity Genetic markers Genetic research Genetic structure Genetic Variation - genetics Genetic Variation - physiology Genetics, Population - methods Genomes Haplotypes Haplotypes - genetics Haplotypes - physiology HeLa Cells Hep G2 Cells Humans Indigenous peoples Loci Markers Methods Mice Minority & ethnic groups Mitochondria Mitochondrial DNA People and Places Peru Population Populations Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Real-Time Polymerase Chain Reaction RNA Interference Short tandem repeats Similarity TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Typing Urban areas Urban Population Urban populations Variability |
| title | Signs of continental ancestry in urban populations of Peru through autosomal STR loci and mitochondrial DNA typing |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T19%3A10%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Signs%20of%20continental%20ancestry%20in%20urban%20populations%20of%20Peru%20through%20autosomal%20STR%20loci%20and%20mitochondrial%20DNA%20typing&rft.jtitle=PloS%20one&rft.au=Messina,%20Francesco&rft.date=2018-07-18&rft.volume=13&rft.issue=7&rft.spage=e0200796&rft.epage=e0200796&rft.pages=e0200796-e0200796&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0200796&rft_dat=%3Cgale_plos_%3EA546918282%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2071541766&rft_id=info:pmid/30020992&rft_galeid=A546918282&rft_doaj_id=oai_doaj_org_article_e3350de9b2fd430bb86d7bf41ba86c81&rfr_iscdi=true |