Translational repression by an RNA-binding protein promotes differentiation to infective forms in Trypanosoma cruzi

Trypanosomes, protozoan parasites of medical importance, essentially rely on post-transcriptional mechanisms to regulate gene expression in insect vectors and vertebrate hosts. RNA binding proteins (RBPs) that associate to the 3'-UTR of mature mRNAs are thought to orchestrate master development...

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Veröffentlicht in:	PLoS pathogens 2018-06, Vol.14 (6), p.e1007059-e1007059
Hauptverfasser:	Romaniuk, Maria Albertina, Frasch, Alberto Carlos, Cassola, Alejandro
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Amastigotes Animals Binding proteins Biology Biology and life sciences Cell cycle Cell Differentiation Cercopithecus aethiops Chagas Disease - parasitology Cytoplasm Differentiation Ectopic expression Epimastigotes Expression vectors Gene expression Gene Expression Regulation Genetic aspects Genomics Glutamine Infective stages Insects Kinases Lysis Medical importance Medicine and Health Sciences Mitochondrial DNA Molecular chains Molecular modelling Morphology Nutrient deficiency Parasites Pathogens Phenotypes Polyribosomes Post-transcription Promoters (Genetics) Protein Processing, Post-Translational Proteins Protozoa Protozoan Proteins - genetics Protozoan Proteins - metabolism Reduction Ribonucleic acid RNA RNA, Messenger - genetics RNA-binding protein RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Tethering trans-Sialidase Translation Trypanosoma brucei Trypanosoma cruzi Trypanosoma cruzi - cytology Trypanosoma cruzi - physiology Trypomastigotes Vero Cells Virulence Virulence factors
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