Distinct expression of the neurotoxic microRNA family let-7 in the cerebrospinal fluid of patients with Alzheimer's disease

MicroRNAs (miRNAs) are non-coding RNAs originally involved in RNA silencing and post-transcriptional regulation of gene expression. We have shown in previous work that the miRNA let-7b can act as a signalling molecule for Toll-like receptor 7, thereby initiating innate immune pathways and apoptosis...

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Veröffentlicht in:	PloS one 2018-07, Vol.13 (7), p.e0200602
Hauptverfasser:	Derkow, Katja, Rössling, Rosa, Schipke, Carola, Krüger, Christina, Bauer, Jakob, Fähling, Michael, Stroux, Andrea, Schott, Eckart, Ruprecht, Klemens, Peters, Oliver, Lehnardt, Seija
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - cerebrospinal fluid Alzheimer's disease Apoptosis Biology Biology and life sciences Biomarkers Brain Cell-Derived Microparticles - metabolism Central nervous system Cerebrospinal fluid Coding Cognitive ability Dementia Dementia disorders Depressive Disorder, Major - cerebrospinal fluid Development and progression Disease control Feasibility studies Female Fluids Frontotemporal Dementia - cerebrospinal fluid Gene expression Gene Expression Regulation Gene regulation Gene silencing Genetic aspects Humans Immune system Male Medicine and Health Sciences MicroRNA MicroRNAs MicroRNAs - cerebrospinal fluid Middle Aged miRNA Molecular chains Multiple sclerosis Neurobiology Neurodegeneration Neurodegenerative diseases Neurological diseases Neurology Neurosciences Neurotoxicity Non-coding RNA Patients Physiological aspects Post-transcription Primers Proteins Ribonucleic acid RNA RNA-mediated interference Signal transduction Toll-like receptors
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