Reducing age bias in decision analyses of anticoagulation for patients with nonvalvular atrial fibrillation - A microsimulation study

Anticoagulation decreases a patient's risk of ischemic stroke and increases the risk of hemorrhage. Decision analyses regarding anticoagulation therefore require that different outcomes be weighted in comparison to one another. Most decision analyses to date have weighted intracranial hemorrhag...

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Veröffentlicht in:	PloS one 2018-07, Vol.13 (7), p.e0199593
Hauptverfasser:	Pappas, Matthew A, Vijan, Sandeep, Rothberg, Michael B, Singer, Daniel E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Age Factors Aged Aged, 80 and over Anticoagulants Anticoagulants - pharmacology Anticoagulants - therapeutic use Atrial Fibrillation - blood Atrial Fibrillation - complications Atrial Fibrillation - epidemiology Bias Biology and Life Sciences Blood Coagulation - drug effects Cardiac arrhythmia Census of Population Complications and side effects Cost analysis Decision analysis Decision making Decision Support Techniques Disease control Dosage and administration Drug dosages Engineering and Technology Estimates Female Fibrillation Health risks Hemorrhage Hospital Mortality Hospitals Humans Internal medicine Intracranial Hemorrhages - etiology Ischemia Life expectancy Life span Male Mathematical models Medicine Medicine and Health Sciences Middle Aged Models, Cardiovascular Monte Carlo Method Monte Carlo simulation Mortality Nutrition Patients Prevention Quality-Adjusted Life Years Research and Analysis Methods Risk factors Severity of Illness Index Stroke Stroke - diagnosis Stroke - epidemiology Stroke - etiology Stroke - prevention & control Thrombolytic Therapy Weighting
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