PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition

Glioblastoma (GBM) is the most common adult primary brain tumor. Multimodal treatment is empiric and prognosis remains poor. Recurrent PIK3CA missense mutations (PIK3CAmut) in GBM are restricted to three functional domains: adaptor binding (ABD), helical, and kinase. Defining how these mutations inf...

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Veröffentlicht in:	PloS one 2018-07, Vol.13 (7), p.e0200014-e0200014
Hauptverfasser:	McNeill, Robert S, Stroobant, Emily E, Smithberger, Erin, Canoutas, Demitra A, Butler, Madison K, Shelton, Abigail K, Patel, Shrey D, Limas, Juanita C, Skinner, Kasey R, Bash, Ryan E, Schmid, Ralf S, Miller, C Ryan
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Analysis Astrocytes Astrocytes - drug effects Astrocytes - metabolism Astrocytes - pathology Biological markers Biology and Life Sciences Biomarkers Brain Brain cancer Brain tumors Cancer therapies Carcinogenesis - drug effects Carcinogenesis - genetics Care and treatment Cell Movement - drug effects Cell Movement - genetics Cell Proliferation - drug effects Cell Proliferation - genetics Cell Transformation, Neoplastic - drug effects Cell Transformation, Neoplastic - genetics Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors Class I Phosphatidylinositol 3-Kinases - genetics Class I Phosphatidylinositol 3-Kinases - metabolism Drug resistance Drug Synergism Enzyme Activation - drug effects Enzyme Activation - genetics Expression vectors Gene expression Glioblastoma Glioblastoma - etiology Glioblastoma - genetics Glioblastomas Humans Inhibitors Kinase inhibitors Kinases Laboratories Medicine Medicine and Health Sciences Migration Missense mutation Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Mutation Mutation, Missense Neurosciences Pathogenesis Patients Prognosis Protein Kinase Inhibitors - pharmacology Research and Analysis Methods Stem cells Synergism Telomerase reverse transcriptase Tumorigenesis
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