Escherichia coli β-clamp slows down DNA polymerase I dependent nick translation while accelerating ligation

The nick translation property of DNA polymerase I (Pol I) ensures the maturation of Okazaki fragments by removing primer RNAs and facilitating ligation. However, prolonged nick translation traversing downstream DNA is an energy wasting futile process, as Pol I simultaneously polymerizes and depolyme...

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Veröffentlicht in:	PloS one 2018-06, Vol.13 (6), p.e0199559-e0199559
Hauptverfasser:	Bhardwaj, Amit, Ghose, Debarghya, Thakur, Krishan Gopal, Dutta, Dipak
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacillus subtilis Bacteria Biology and Life Sciences Deoxyribonucleic acid Depolymerization Displacement activity DNA DNA polymerase DNA repair DNA-directed DNA polymerase E coli Escherichia coli Exonuclease Flaps Fragments Maturation Nucleotides Okazaki fragments Oligonucleotides Physical Sciences Polypeptides Research and Analysis Methods Substrate inhibition Translation
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