Voxel-based 18F-FET PET segmentation and automatic clustering of tumor voxels: A significant association with IDH1 mutation status and survival in patients with gliomas

Aim was to develop a full automatic clustering approach of the time-activity curves (TAC) from dynamic 18F-FET PET and evaluate its association with IDH1 mutation status and survival in patients with gliomas. Thirty-seven patients (mean age: 45±13 y) with newly diagnosed gliomas and dynamic 18F-FET...

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Veröffentlicht in:	PloS one 2018-06, Vol.13 (6), p.e0199379-e0199379
Hauptverfasser:	Blanc-Durand, Paul, Van Der Gucht, Axel, Verger, Antoine, Langen, Karl-Josef, Dunet, Vincent, Bloch, Jocelyne, Brouland, Jean-Philippe, Nicod-Lalonde, Marie, Schaefer, Niklaus, Prior, John O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bioengineering Biology and Life Sciences Biomarkers Biomarkers, Tumor Biopsy Brain Brain cancer Brain mapping Brain tumors Centroids Cluster Analysis Clustering Computer Science Dehydrogenases Diagnostic systems Female Follow-Up Studies Glioma Glioma - diagnostic imaging Glioma - genetics Glioma - mortality Glioma - pathology Hospitals Human health and pathology Humans Image processing Image Processing, Computer-Assisted Image segmentation Isocitrate Dehydrogenase - genetics Kaplan-Meier Estimate Life Sciences Male Medical diagnosis Medical Imaging Medical prognosis Medicine and Health Sciences Middle Aged Mutation Neoplasm Grading Neoplasm Staging Nervous system NMR Nuclear magnetic resonance Nuclear medicine Parameters Patients Positron emission Positron emission tomography Positron Emission Tomography Computed Tomography Prognosis Research and Analysis Methods Slopes Survival Tomography Tumors Tyrosine - analogs & derivatives Vector quantization Verger Working groups
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