A subset of octopaminergic neurons that promotes feeding initiation in Drosophila melanogaster
Octopamine regulates feeding behavioral responses in Drosophila melanogaster, however the molecular and circuit mechanisms have not been fully elucidated. Here, we investigated the role of a subset of octopaminergic neurons, the OA-VPM4 cluster, in sucrose acceptance behavior. Thermogenetic activati...
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| description | Octopamine regulates feeding behavioral responses in Drosophila melanogaster, however the molecular and circuit mechanisms have not been fully elucidated. Here, we investigated the role of a subset of octopaminergic neurons, the OA-VPM4 cluster, in sucrose acceptance behavior. Thermogenetic activation of Gal4 lines containing OA-VPM4 promoted proboscis extension to sucrose, while optogenetic inactivation reduced extension. Anatomically, the presynaptic terminals of OA-VPM4 are in close proximity to the axons of sugar-responsive gustatory sensory neurons. Moreover, RNAi knockdown of a specific class of octopamine receptor, OAMB, selectively in sugar-sensing gustatory neurons decreased the behavioral response to sucrose. By calcium imaging experiments, we found that application of octopamine potentiates sensory responses to sucrose in satiated flies. Taken together, these findings suggest a model by which OA-VPM4 promotes feeding behavior by modulating the activity of sensory neurons. |
| doi_str_mv | 10.1371/journal.pone.0198362 |
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Here, we investigated the role of a subset of octopaminergic neurons, the OA-VPM4 cluster, in sucrose acceptance behavior. Thermogenetic activation of Gal4 lines containing OA-VPM4 promoted proboscis extension to sucrose, while optogenetic inactivation reduced extension. Anatomically, the presynaptic terminals of OA-VPM4 are in close proximity to the axons of sugar-responsive gustatory sensory neurons. Moreover, RNAi knockdown of a specific class of octopamine receptor, OAMB, selectively in sugar-sensing gustatory neurons decreased the behavioral response to sucrose. By calcium imaging experiments, we found that application of octopamine potentiates sensory responses to sucrose in satiated flies. Taken together, these findings suggest a model by which OA-VPM4 promotes feeding behavior by modulating the activity of sensory neurons.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0198362</identifier><identifier>PMID: 29949586</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animal feeding behavior ; Animals ; Axons ; Behavior ; Biology ; Biology and Life Sciences ; Biometrics ; Brain research ; Calcium ; Calcium imaging ; Cell Line ; Deactivation ; Drosophila ; Drosophila melanogaster ; Drosophila melanogaster - physiology ; Drosophila Proteins - metabolism ; Feeding ; Feeding behavior ; Feeding Behavior - physiology ; Food ; Gene expression ; Genetic aspects ; Genotypes ; Inactivation ; Insects ; Laboratories ; Medicine and Health Sciences ; Molecular chains ; Neurons ; Neurosciences ; Octopamine ; Octopamine - metabolism ; Optogenetics ; Pheromones ; Physical Sciences ; Presynaptic Terminals - metabolism ; Proboscis ; Properties ; Receptors, Neurotransmitter - metabolism ; Research and Analysis Methods ; RNA-mediated interference ; Sensory neurons ; Sensory Receptor Cells - metabolism ; Sensory receptors ; Social Sciences ; Sucrose ; Sucrose - pharmacology ; Sugar ; Taste Perception</subject><ispartof>PloS one, 2018-06, Vol.13 (6), p.e0198362-e0198362</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Youn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Youn, Hyesoo</au><au>Kirkhart, Colleen</au><au>Chia, Justine</au><au>Scott, Kristin</au><au>Marion-Poll, Frederic</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A subset of octopaminergic neurons that promotes feeding initiation in Drosophila melanogaster</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-06-27</date><risdate>2018</risdate><volume>13</volume><issue>6</issue><spage>e0198362</spage><epage>e0198362</epage><pages>e0198362-e0198362</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Octopamine regulates feeding behavioral responses in Drosophila melanogaster, however the molecular and circuit mechanisms have not been fully elucidated. Here, we investigated the role of a subset of octopaminergic neurons, the OA-VPM4 cluster, in sucrose acceptance behavior. Thermogenetic activation of Gal4 lines containing OA-VPM4 promoted proboscis extension to sucrose, while optogenetic inactivation reduced extension. Anatomically, the presynaptic terminals of OA-VPM4 are in close proximity to the axons of sugar-responsive gustatory sensory neurons. Moreover, RNAi knockdown of a specific class of octopamine receptor, OAMB, selectively in sugar-sensing gustatory neurons decreased the behavioral response to sucrose. By calcium imaging experiments, we found that application of octopamine potentiates sensory responses to sucrose in satiated flies. Taken together, these findings suggest a model by which OA-VPM4 promotes feeding behavior by modulating the activity of sensory neurons.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29949586</pmid><doi>10.1371/journal.pone.0198362</doi><tpages>e0198362</tpages><orcidid>https://orcid.org/0000-0003-3150-7210</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animal feeding behavior Animals Axons Behavior Biology Biology and Life Sciences Biometrics Brain research Calcium Calcium imaging Cell Line Deactivation Drosophila Drosophila melanogaster Drosophila melanogaster - physiology Drosophila Proteins - metabolism Feeding Feeding behavior Feeding Behavior - physiology Food Gene expression Genetic aspects Genotypes Inactivation Insects Laboratories Medicine and Health Sciences Molecular chains Neurons Neurosciences Octopamine Octopamine - metabolism Optogenetics Pheromones Physical Sciences Presynaptic Terminals - metabolism Proboscis Properties Receptors, Neurotransmitter - metabolism Research and Analysis Methods RNA-mediated interference Sensory neurons Sensory Receptor Cells - metabolism Sensory receptors Social Sciences Sucrose Sucrose - pharmacology Sugar Taste Perception |
| title | A subset of octopaminergic neurons that promotes feeding initiation in Drosophila melanogaster |
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