Sequence characteristics define trade-offs between on-target and genome-wide off-target hybridization of oligoprobes

Off-target oligoprobe's interaction with partially complementary nucleotide sequences represents a problem for many bio-techniques. The goal of the study was to identify oligoprobe sequence characteristics that control the ratio between on-target and off-target hybridization. To understand the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2018-06, Vol.13 (6), p.e0199162-e0199162
Hauptverfasser:	Matveeva, Olga V, Ogurtsov, Aleksey Y, Nazipova, Nafisa N, Shabalina, Svetlana A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Arrays Base Sequence Binding energy Binding sites Bioinformatics Biology and Life Sciences Biotechnology Data bases Databases, Genetic Deoxyribonucleic acid DNA DNA probes DNA sequencing Energy Genome Genomes Humans Hybridization Mathematical problems Medical research National libraries Nucleic Acid Hybridization Nucleotide sequence Nucleotides Oligonucleotide Array Sequence Analysis - methods Probes Research and Analysis Methods Thermodynamics Tiling
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!