CXCR7 expression in diffuse large B-cell lymphoma identifies a subgroup of CXCR4+ patients with good prognosis

The CXCR4/CXCL12 axis has been extensively associated with different types of cancer correlating with higher aggressiveness and metastasis. In diffuse large B-cell lymphoma (DLBCL), the expression of the chemokine receptor CXCR4 is involved in the dissemination of malignant B cells and is a marker o...

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Veröffentlicht in:	PloS one 2018-06, Vol.13 (6), p.e0198789-e0198789
Hauptverfasser:	Moreno, María José, Gallardo, Alberto, Novelli, Silvana, Mozos, Ana, Aragó, Marc, Pavón, Miguel Ángel, Céspedes, María Virtudes, Pallarès, Víctor, Falgàs, Aïda, Alcoceba, Miguel, Blanco, Oscar, Gonzalez-Díaz, Marcos, Sierra, Jorge, Mangues, Ramon, Casanova, Isolda
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged B-cell lymphoma Biology and Life Sciences Biomarkers, Tumor Biomedical research Biopsy Breast cancer Cancer Carcinogenesis Cell adhesion & migration Cell Line, Tumor Cell survival Chemokine CXCL12 - physiology Chemokines CXCL12 protein CXCR4 protein Càncer Drug Resistance, Neoplasm - genetics Female Gene Expression Regulation, Neoplastic Hematology Humans Isolda Kaplan-Meier Estimate Limfomes Lymphocytes B Lymphocytic leukemia Lymphoma Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - metabolism Lymphoma, Large B-Cell, Diffuse - mortality Lymphoma, Large B-Cell, Diffuse - pathology Lymphomas Male Marcadors tumorals Medical prognosis Medical research Medicine and Health Sciences Metastases Metastasis Metàstasi Middle Aged Molecular chains Molecular modelling Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Proteins - physiology Pathology Patients Prognosis Pronòstic mèdic Proportional Hazards Models Quimiocines Receptors, CXCR - biosynthesis Receptors, CXCR - genetics Receptors, CXCR - physiology Receptors, CXCR4 - analysis Research and Analysis Methods Subgroups Survival Tumor markers
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