Enhancement of bradykinin-induced relaxation by focal brain ischemia in the rat middle cerebral artery: Receptor expression upregulation and activation of multiple pathways

Focal brain ischemia markedly affects cerebrovascular reactivity. So far, these changes have mainly been related to alterations in the level of smooth muscle cell function while alterations of the endothelial lining have not yet been studied in detail. We have, therefore, investigated the effects of...

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Veröffentlicht in:	PloS one 2018-06, Vol.13 (6), p.e0198553-e0198553
Hauptverfasser:	Li, Youhai, Lapina, Natalia, Weinzierl, Nina, Schilling, Lothar
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Analysis Animals Arteries Biology and Life Sciences Bradykinin Bradykinin - pharmacology Brain Brain Ischemia - physiopathology Brain research Cardiovascular system Carotid arteries Cerebral arteries Cerebral blood flow Cerebral ischemia Cerebrovascular system Charybdotoxin Cyclic GMP Denudation Dosage and administration Dose-Response Relationship, Drug Edema Endothelial cells Endothelium Gene expression Guanylate cyclase Health aspects Hyperpolarization Immunofluorescence Injuries Ischemia Laboratory animals Male Medicine and Health Sciences Middle Cerebral Artery - drug effects Middle Cerebral Artery - physiopathology mRNA Muscle Relaxation - drug effects Muscle Relaxation - physiology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiopathology Muscles Nitric oxide Occlusion Proteins Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Receptor mechanisms Receptor, Bradykinin B1 - metabolism Receptor, Bradykinin B2 - metabolism Receptors, Bradykinin - metabolism Relaxation techniques (Psychology) Reperfusion Reperfusion Injury - physiopathology Research and Analysis Methods Rodents Smooth muscle Stroke Trauma Up-Regulation - drug effects Veins & arteries
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