Non-canonical role of the SNARE protein Ykt6 in autophagosome-lysosome fusion

The autophagosomal SNARE Syntaxin17 (Syx17) forms a complex with Snap29 and Vamp7/8 to promote autophagosome-lysosome fusion via multiple interactions with the tethering complex HOPS. Here we demonstrate that, unexpectedly, one more SNARE (Ykt6) is also required for autophagosome clearance in Drosop...

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Veröffentlicht in:	PLoS genetics 2018-04, Vol.14 (4), p.e1007359-e1007359
Hauptverfasser:	Takáts, Szabolcs, Glatz, Gábor, Szenci, Győző, Boda, Attila, Horváth, Gábor V, Hegedűs, Krisztina, Kovács, Attila L, Juhász, Gábor
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Animals, Genetically Modified Autophagosomes - physiology Autophagy Binding Sites Biology and Life Sciences Developmental biology Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - physiology Drosophila Proteins - genetics Drosophila Proteins - physiology Funding Fusion protein Golgi apparatus Insects Lysosomes Lysosomes - physiology Medicine and Health Sciences Membrane fusion Membrane Fusion - genetics Membrane Fusion - physiology Models, Biological Multiprotein Complexes - genetics Multiprotein Complexes - physiology Observations Palmitoylation Phagosomes Proteins Qa-SNARE Proteins - genetics Qa-SNARE Proteins - physiology R-SNARE Proteins - genetics R-SNARE Proteins - physiology Recombinant Proteins - genetics Recombinant Proteins - metabolism Research and Analysis Methods SNAP receptors SNARE Proteins - genetics SNARE Proteins - physiology
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